Zobrazeno 1 - 10
of 20
pro vyhledávání: '"Stephen Challenger"'
Autor:
Jean-Philippe Crochard, Melissa Birch, Amy Luan, Jinu S. Mathew, Philip Peach, Neil McDowall, David Sebastien Fradet, Stephen Challenger, Kevin Meldrum, Charles M. Gordon, Hayley Jackman, Stephen Yeo, Evelyn Madigan
Publikováno v:
Organic Process Research & Development. 15:1358-1364
The development of a highly efficient two-step process for the manufacture of the α2δ-ligand imagabalin hydrochloride 1 is described in 50% overall yield from (R)-3-methylhexanoic acid 2. Key aspec...
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::9685f05fa65964e82bc79b3bfd7a2f4a
https://doi.org/10.1021/op2002326
https://doi.org/10.1021/op2002326
Autor:
Magnus Widegren, Hayley Jackman, Jean-Philippe Crochard, Melissa Birch, Kevin Meldrum, Stephen Challenger, Amy Luan, David Sebastien Fradet, Neil McDowall, Charles M. Gordon, Evelyn Madigan, Stephen Yeo
Publikováno v:
Organic Process Research & Development. 15:1172-1177
The development and implementation of a robust process for the manufacture of metric ton quantities of the α2δ ligand imagabalin hydrochloride 4 is described. Key aspects of the synthesis include a...
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::f0675fe296642f354a99b5be242772fb
https://doi.org/10.1021/op2001639
https://doi.org/10.1021/op2001639
Autor:
Smith Julian Duncan, Stephen Challenger, Alan John Pettman, Fox Darrell E, Pierre Pascal, Lynsey C. Hesmondhalgh, Yann Dessi
Publikováno v:
Organic Process Research & Development. 12:575-583
The development and utilization of a scaleable process for the manufacture of the A2a agonist UK-371,104 (1) is described. Key steps in the synthesis include (i) a palladium-catalyzed cyanation reaction to prepare the nitrile 10, (ii) a telescoped co
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::00f75768328e2dd8d4fe7176397ea66a
https://doi.org/10.1021/op700248t
https://doi.org/10.1021/op700248t
Autor:
David Clifford, John R. Williams, Terry V. Silk, Christopher P. Ashcroft, Nicholas Murray Thomson, Yousef Hajikarimian, Andrew Derrick, Keith Slucock, Stephen Challenger
Publikováno v:
Organic Process Research & Development. 9:663-669
The development and scale-up of a potential manufacturing route to the endothelin antagonists UK-350,926 1 and UK-349,862 2 are described. A key synthetic challenge in designing an efficient route ...
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::4b28966a20dd48524c7fffef95182190
https://doi.org/10.1021/op050102f
https://doi.org/10.1021/op050102f
Autor:
Stephen Challenger, Nicholas Murray Thomson, Richard Storey, Andrew Derrick, Christopher P. Ashcroft
Publikováno v:
Organic Process Research & Development. 7:362-368
An efficient and practical synthesis is presented of the pharmaceutically active MMP-3 inhibitor UK-370,106 (1) via an olefination/catalytic asymmetric hydrogenation sequence. Commercially available 5-bromo-2-iodotoluene was converted in two steps to
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::430871353b5335fb998509405cb56a50
https://doi.org/10.1021/op034001y
https://doi.org/10.1021/op034001y
Publikováno v:
Tetrahedron Letters. 40:2187-2190
A four step synthesis of a chiral glutarate half ester intermediate, required for the preparation of candoxatril, has been developed from t-butyl acrylate. The key steps in this route include a stereoselective synthesis of a trisubstituted alkene and
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::37c957235291012d17796cb31e658c10
https://doi.org/10.1016/s0040-4039(98)02687-2
https://doi.org/10.1016/s0040-4039(98)02687-2
Autor:
Stephen Challenger
Publikováno v:
ChemInform. 27
This chapter reviews the transformations that have been used to prepare imidoylsulfur, -selenium, and -tellurium derivatives with particular emphasis on newer methods that have been published since 1993. Thioimidic esters, which are often called thio
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::ce3df82fd0ecadaa67508765e7dc2783
https://doi.org/10.1002/chin.199631298
https://doi.org/10.1002/chin.199631298
Publikováno v:
ChemInform. 30
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::9728698fad62e2e65f578f1ecd445cf1
https://doi.org/10.1002/chin.199924056
https://doi.org/10.1002/chin.199924056
Publikováno v:
Carbohydrate Research. 202:81-92
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::0e8867b79c4d7f1194e1c2a205911389
https://doi.org/10.1016/0008-6215(90)84072-3
https://doi.org/10.1016/0008-6215(90)84072-3
Autor:
Nicholas Murray Thomson, Stephen Challenger, Yousef Hajikarimian, Christopher P. Ashcroft, Andrew Derrick
Publikováno v:
Process Chemistry in the Pharmaceutical Industry, Volume 2: Challenges in an Ever Changing Climate
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::8c2f27f5f209797a2eaf5a8372451bc7
https://doi.org/10.1201/9781420008357.ch10
https://doi.org/10.1201/9781420008357.ch10
