Zobrazeno 1 - 10
of 21
pro vyhledávání: '"Stephen, Zicha"'
Autor:
Liam Mahedy, Emma L. Anderson, Kate Tilling, Zak A. Thornton, Andrew R. Elmore, Sándor Szalma, Arthur Simen, Meredith Culp, Stephen Zicha, Brian T. Harel, George Davey Smith, Erin N. Smith, Lavinia Paternoster
Publikováno v:
Translational Psychiatry, Vol 14, Iss 1, Pp 1-11 (2024)
Abstract Cognitive decline is a major health concern and identification of genes that may serve as drug targets to slow decline is important to adequately support an aging population. Whilst genetic studies of cross-sectional cognition have been carr
Externí odkaz:
https://doaj.org/article/7c74e97413254aebba9b6708c2e881d5
Autor:
Nellie Georgiou-Karistianis, Louise A Corben, Kathrin Reetz, Isaac M Adanyeguh, Manuela Corti, Dinesh K Deelchand, Martin B Delatycki, Imis Dogan, Rebecca Evans, Jennifer Farmer, Marcondes C França, William Gaetz, Ian H Harding, Karen S Harris, Steven Hersch, Richard Joules, James J Joers, Michelle L Krishnan, Michelle Lax, Eric F Lock, David Lynch, Thomas Mareci, Sahan Muthuhetti Gamage, Massimo Pandolfo, Marina Papoutsi, Thiago J R Rezende, Timothy P L Roberts, Jens T Rosenberg, Sandro Romanzetti, Jörg B Schulz, Traci Schilling, Adam J Schwarz, Sub Subramony, Bert Yao, Stephen Zicha, Christophe Lenglet, Pierre-Gilles Henry
Publikováno v:
PLoS ONE, Vol 17, Iss 11, p e0269649 (2022)
IntroductionDrug development for neurodegenerative diseases such as Friedreich's ataxia (FRDA) is limited by a lack of validated, sensitive biomarkers of pharmacodynamic response in affected tissue and disease progression. Studies employing neuroimag
Externí odkaz:
https://doaj.org/article/13b6892396fd4fd9b5968cce8f1724fb
Autor:
Jaya Padmanabhan, Elena Ratti, Polyna Khudyakov, Wei Yin, Stephen Zicha, Olga Golonzhka, Tairmae Kangarloo, Brian Harel, Nancy Goodman, Emmanuelle Magueur, Craig Shering, Thor Ostenfeld, Antonio Laurenza, Arthur Simen
Publikováno v:
Tuesday, April 25.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::261966b3c44c6a73808d8a3590adb1e2
https://doi.org/10.1212/wnl.0000000000201834
https://doi.org/10.1212/wnl.0000000000201834
ObjectiveMotor neuron disease (MND) is a debilitating neurodegenerative disease with profound unmet need. In pre-symptomatic mutation carriers, elevations in neurofilament light (NfL) precede symptom onset, however, the presence and timing of elevati
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::eb828311553b5610230a87cf6da545a6
https://doi.org/10.1101/2023.02.27.23286529
https://doi.org/10.1101/2023.02.27.23286529
Autor:
Stephen, Zicha, Randall J, Bateman, Leslie M, Shaw, Henrik, Zetterberg, Anthony W, Bannon, Wesley A, Horton, Mike, Baratta, Hartmuth C, Kolb, Iwona, Dobler, Yulia, Mordashova, Ziad S, Saad, David L, Raunig, Emmanouil Manos, Spanakis, Yan, Li, Suzanne E, Schindler, Kyle, Ferber, Carrie E, Rubel, Robert L, Martone, Christopher J, Weber, Rebecca M, Edelmayer, Emily A, Meyers, James G, Bollinger, Erin G, Rosenbaugh, William Z, Potter
Publikováno v:
Alzheimer'sdementia : the journal of the Alzheimer's AssociationREFERENCES.
This report details the approach taken to providing a dataset allowing for analyses on the performance of recently developed assays of amyloid beta (Aβ) peptides in plasma and the extent to which they improve the prediction of amyloid positivity.Alz
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::4f92a7bdcb46d9e104e3c909a55d9d98
https://pubmed.ncbi.nlm.nih.gov/35820077
https://pubmed.ncbi.nlm.nih.gov/35820077
Autor:
Clifford J. Woolf, Martin Aichinger, Stephen Zicha, Bruna Lenfers Turnes, Markus Seifert, Luigi Tortola, Guenther Lametschwandtner, Magdalena Paolino, Mark Joseph Tebbe, Michael Costigan, Melanie Kogler, Gerald Wirnsberger, Simon C. Robson, Keith M. Channon, Yann Pierson, Débora da Luz Scheffer, Maria Novatchkova, Ari Waisman, Guenter Weiss, Andrey V. Kozlov, Maria Serena Longhi, Alexandra Latini, Taras Kreslavsky, Shane J. F. Cronin, Alexander Jais, David Hoffmann, Lee Barrett, Sonja Reissig, Sébastien Talbot, Kai Johnsson, Manu Rangachari, Adelheid Weidinger, Alban Latremoliere, Domagoj Cikes, Shuan Rao, Josef M. Penninger, Meinrad Busslinger, Corey R. Seehus, Eileen McNeill, Nick Andrews, Melita Ticevic
Publikováno v:
Nature. 572:E18-E18
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::6d376410593f76a092aafcad5101a573
https://doi.org/10.1038/s41586-019-1459-x
https://doi.org/10.1038/s41586-019-1459-x
Autor:
Tarek Z. Deeb, Mark E. Duggan, Jamie Maguire, Nicholas J. Brandon, Stephen J. Moss, Liliya Silayeva, Matt R. Kelley, John Dunlop, Sudhir Sivakumaran, Stephen Zicha, Robert J. Mather, Ross A. Cardarelli, Yvonne E. Moore, Jayanta Mukherjee, Danielle H. Morrow
Publikováno v:
The Journal of neuroscience : the official journal of the Society for Neuroscience. 35(21)
GABAAreceptors form Cl−permeable channels that mediate the majority of fast synaptic inhibition in the brain. The K+/Cl−cotransporter KCC2 is the main mechanism by which neurons establish low intracellular Cl−levels, which is thought to enable
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fd0dd6f9d7499ff8024bc6dda7edce13
https://pubmed.ncbi.nlm.nih.gov/26019342
https://pubmed.ncbi.nlm.nih.gov/26019342
Publikováno v:
Current Pharmaceutical Design. 11:1959-1974
Cardiac arrhythmias remain a major source of morbidity and mortality in developed countries. Antiarrhythmic drug therapy was traditionally the mainstay of cardiac arrhythmia treatment; however, drug therapy of cardiac arrhythmias has been plagued by
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a7b523cd225d8cfe09af8defecef1409
https://doi.org/10.2174/1381612054021051
https://doi.org/10.2174/1381612054021051
Publikováno v:
The Journal of Physiology. 561:735-748
The transient outward current (Ito), an important contributor to transmural electrophysiological heterogeneity, is significantly remodelled in congestive heart failure (CHF). The molecular bases of transmural Ito gradients and CHF-dependent ionic rem
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::34a589010e5b80f7709389d0883485d2
https://doi.org/10.1113/jphysiol.2004.075861
https://doi.org/10.1113/jphysiol.2004.075861
Autor:
Isaac L. Moss, Julius Gy. Papp, Stanley Nattel, Robert Dumaine, András Varró, Charles Antzelevich, Bruce G. Allen, Stephen Zicha
Publikováno v:
American Journal of Physiology-Heart and Circulatory Physiology. 285:H1641-H1649
There are important species-specific differences in K+current profiles and arrhythmia susceptibility, but interspecies comparisons of K+channel subunit expression are lacking. We quantified voltage-gated K+channel (Kv) subunit mRNA and protein in rab
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e1a7bbb85bcf2cef8b3205f3d903d758
https://doi.org/10.1152/ajpheart.00346.2003
https://doi.org/10.1152/ajpheart.00346.2003