Zobrazeno 1 - 8
of 8
pro vyhledávání: '"Stephen, Verespy"'
Autor:
Rami A. Al-Horani, Rio S. Boothello, Stephen Verespy, Rajesh Karuturi, Umesh R. Desai, Daniel K. Afosah
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 28:1101-1105
Despite the development of promising direct oral anticoagulants, which are all orthosteric inhibitors, a sizable number of patients suffer from bleeding complications. We have hypothesized that allosterism based on the heparin-binding exosites presen
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8f40f888fe19676449767b0be0a6826e
https://doi.org/10.1016/j.bmcl.2018.01.069
https://doi.org/10.1016/j.bmcl.2018.01.069
Publikováno v:
Faraday Discuss
Faraday discussions, vol 219, iss 0
Faraday discussions, vol 219, iss 0
In the mucosal epithelium, the cellular glycocalyx can project tens to hundreds of nanometers into the extracellular space, erecting a physical barrier that provides protective functions, mediates the exchange of nutrients and regulates cellular inte
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a9348cbbbe82bd83cc5258622381dd5e
https://pubmed.ncbi.nlm.nih.gov/31313786
https://pubmed.ncbi.nlm.nih.gov/31313786
Publikováno v:
Bioconjugate chemistry, vol 30, iss 3
Heparan sulfate glycosaminoglycans (HS GAGs) attached to proteoglycans harbor high affinity binding sites for various growth factors (GFs) and direct their organization and activity across the cell-matrix interface. Here, we describe a mild and effic
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::25271c7c39b993c864edf68b606f9d50
https://pubmed.ncbi.nlm.nih.gov/30668905
https://pubmed.ncbi.nlm.nih.gov/30668905
Publikováno v:
Current protocols in chemical biology. 10(2)
This article describes a protocol for remodeling cells with synthetic glycoprotein and glycolipid mimetics that are functionalized with lipid anchors, allowing for cell surface display of specific glycan structures in predefined nanoscale arrangement
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2f84444215483b4fb1adf1932d0b5aec
https://pubmed.ncbi.nlm.nih.gov/29927116
https://pubmed.ncbi.nlm.nih.gov/29927116
Publikováno v:
ChemInform. 47
In nearly all cases of biological activity of sulfated GAGs, the sulfate group(s) are critical for interacting with target proteins. A growing paradigm is that appropriate small, sulfated, nonsaccharide GAG mimetics can be designed to either mimic or
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::7fefcc2a4633b83734cff2f9d0a5ccae
https://doi.org/10.1002/chin.201634216
https://doi.org/10.1002/chin.201634216
Publikováno v:
Scientific Reports
Allosteric partial inhibition of soluble, monomeric proteases can offer major regulatory advantages, but remains a concept on paper to date; although it has been routinely documented for receptors and oligomeric proteins. Thrombin, a key protease of
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::253a7c1fc23c10dd85c3fdd837e97b05
https://doi.org/10.1038/srep24043
https://doi.org/10.1038/srep24043
Publikováno v:
Methods in molecular biology (Clifton, N.J.). 1229
In nearly all cases of biological activity of sulfated GAGs, the sulfate group(s) are critical for interacting with target proteins. A growing paradigm is that appropriate small, sulfated, nonsaccharide GAG mimetics can be designed to either mimic or
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::0ee07662cdd0172da736bf2390ccb3e5
https://pubmed.ncbi.nlm.nih.gov/25325944
https://pubmed.ncbi.nlm.nih.gov/25325944
Publikováno v:
Methods in Molecular Biology ISBN: 9781493917136
In nearly all cases of biological activity of sulfated GAGs, the sulfate group(s) are critical for interacting with target proteins. A growing paradigm is that appropriate small, sulfated, nonsaccharide GAG mimetics can be designed to either mimic or
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::90d64fa0f6bb45fe8d1818af329abe01
https://doi.org/10.1007/978-1-4939-1714-3_7
https://doi.org/10.1007/978-1-4939-1714-3_7
