Zobrazeno 1 - 10
of 553
pro vyhledávání: '"Stephen, O'Rahilly"'
Autor:
John W. R. Kincaid, Debra Rimmington, John A. Tadross, Irene Cimino, Ilona Zvetkova, Arthur Kaser, Paul Richards, Satish Patel, Stephen O’Rahilly, Anthony P. Coll
Publikováno v:
Scientific Reports, Vol 14, Iss 1, Pp 1-13 (2024)
Abstract The hormone GDF15 is secreted in response to cellular stressors. Metformin elevates circulating levels of GDF15, an action important for the drug’s beneficial effects on body weight. Metformin can also inhibit mammalian respiratory complex
Externí odkaz:
https://doaj.org/article/36d415474a95447299258e0b0a1879b6
Autor:
Jake P Mann, Xiaowen Duan, Satish Patel, Luis Carlos Tábara, Fabio Scurria, Anna Alvarez-Guaita, Afreen Haider, Ineke Luijten, Matthew Page, Margherita Protasoni, Koini Lim, Sam Virtue, Stephen O'Rahilly, Martin Armstrong, Julien Prudent, Robert K Semple, David B Savage
Publikováno v:
eLife, Vol 12 (2023)
Mitochondrial dysfunction has been reported in obesity and insulin resistance, but primary genetic mitochondrial dysfunction is generally not associated with these, arguing against a straightforward causal relationship. A rare exception, recently ide
Externí odkaz:
https://doaj.org/article/10fcb30f48a744fd966e20290cf355fb
Autor:
Irene Cimino, Debra Rimmington, Y. C. Loraine Tung, Katherine Lawler, Pierre Larraufie, Richard G. Kay, Samuel Virtue, Brian Y. H. Lam, Luca Fagnocchi, Marcella K. L. Ma, Vladimir Saudek, Ilona Zvetkova, Antonio Vidal-Puig, Giles S. H. Yeo, I. Sadaf Farooqi, J. Andrew Pospisilik, Fiona M. Gribble, Frank Reimann, Stephen O’Rahilly, Anthony P. Coll
Publikováno v:
Scientific Reports, Vol 11, Iss 1, Pp 1-15 (2021)
Abstract Neuronatin (Nnat) has previously been reported to be part of a network of imprinted genes downstream of the chromatin regulator Trim28. Disruption of Trim28 or of members of this network, including neuronatin, results in an unusual phenotype
Externí odkaz:
https://doaj.org/article/e7d5a888c2a540aeac4077803967b5d5
Autor:
Satish Patel, Afreen Haider, Anna Alvarez-Guaita, Guillaume Bidault, Julia Sarah El-Sayed Moustafa, Esther Guiu-Jurado, John A. Tadross, James Warner, James Harrison, Samuel Virtue, Fabio Scurria, Ilona Zvetkova, Matthias Blüher, Kerrin S. Small, Stephen O’Rahilly, David B. Savage
Publikováno v:
Molecular Metabolism, Vol 65, Iss , Pp 101589- (2022)
Objectives: Obesity in humans and mice is associated with elevated levels of two hormones responsive to cellular stress, namely GDF15 and FGF21. Over-expression of each of these is associated with weight loss and beneficial metabolic changes but wher
Externí odkaz:
https://doaj.org/article/86d575de029d49f1be5d61f2c525a70f
Autor:
Ming Yang, Tamana Darwish, Pierre Larraufie, Debra Rimmington, Irene Cimino, Deborah A. Goldspink, Benjamin Jenkins, Albert Koulman, Cheryl A. Brighton, Marcella Ma, Brian Y. H. Lam, Anthony P. Coll, Stephen O’Rahilly, Frank Reimann, Fiona M. Gribble
Publikováno v:
Scientific Reports, Vol 11, Iss 1, Pp 1-20 (2021)
Abstract Even though metformin is widely used to treat type2 diabetes, reducing glycaemia and body weight, the mechanisms of action are still elusive. Recent studies have identified the gastrointestinal tract as an important site of action. Here we u
Externí odkaz:
https://doaj.org/article/3277fbedd1ef4a0488a75dc21d27c7a7
Obesity is one of the most important contributing factors to disease throughout the world and is an area of great current interest among researchers and clinicians. The genetics of common obesity is complex, and an important thread through this labyr
Autor:
Yongjie Yang, Agatha A. van der Klaauw, Liangru Zhu, Tessa M. Cacciottolo, Yanlin He, Lukas K. J. Stadler, Chunmei Wang, Pingwen Xu, Kenji Saito, Antentor Hinton, Xiaofeng Yan, Julia M. Keogh, Elana Henning, Matthew C. Banton, Audrey E. Hendricks, Elena G. Bochukova, Vanisha Mistry, Katherine L. Lawler, Lan Liao, Jianming Xu, Stephen O’Rahilly, Qingchun Tong, UK10K Consortium, Inês Barroso, Bert W. O’Malley, I. Sadaf Farooqi, Yong Xu
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-14 (2019)
Neurons expressing pro-opiomelanocortin (Pomc) regulate food intake and body weight. Here the authors show that Steroid Receptor Coactivator-1 (SRC-1) regulates the function of Pomc expressing neurons, and that rare heterozygous variants found in obe
Externí odkaz:
https://doaj.org/article/1d82850af2594a8381d4f4b41b3524ec
Autor:
Miriam Ferrer, Tracy G. Anthony, Janelle S. Ayres, Giulia Biffi, Justin C. Brown, Bette J. Caan, Elizabeth M. Cespedes Feliciano, Anthony P. Coll, Richard F. Dunne, Marcus D. Goncalves, Jonas Grethlein, Steven B. Heymsfield, Sheng Hui, Mariam Jamal-Hanjani, Jie Min Lam, David Y. Lewis, David McCandlish, Karen M. Mustian, Stephen O’Rahilly, Norbert Perrimon, Eileen P. White, Tobias Janowitz
Publikováno v:
Cell. 186:1824-1845
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::df74b60a74581bc8dfcac2f5b065f22d
https://doi.org/10.1016/j.cell.2023.03.028
https://doi.org/10.1016/j.cell.2023.03.028
Autor:
Anna Alvarez-Guaita, Satish Patel, Koini Lim, Afreen Haider, Liang Dong, Olivia J. Conway, Marcella K.L. Ma, Davide Chiarugi, Vladimir Saudek, Stephen O’Rahilly, David B. Savage
Publikováno v:
Cell Reports, Vol 34, Iss 10, Pp 108810- (2021)
Summary: Adipogenin (Adig) is an adipocyte-enriched transmembrane protein. Its expression is induced during adipogenesis in rodent cells, and a recent genome-wide association study associated body mass index (BMI)-adjusted leptin levels with the ADIG
Externí odkaz:
https://doaj.org/article/429f6fb808504b2db108fb2f69b10633
Autor:
K. Alaine Broadaway, Xianyong Yin, Alice Williamson, Victoria A. Parsons, Emma P. Wilson, Anne H. Moxley, Swarooparani Vadlamudi, Arushi Varshney, Anne U. Jackson, Vasudha Ahuja, Stefan R. Bornstein, Laura J. Corbin, Graciela E. Delgado, Om P. Dwivedi, Lilian Fernandes Silva, Timothy M. Frayling, Harald Grallert, Stefan Gustafsson, Liisa Hakaste, Ulf Hammar, Christian Herder, Sandra Herrmann, Kurt Højlund, David A. Hughes, Marcus E. Kleber, Cecilia M. Lindgren, Ching-Ti Liu, Jian’an Luan, Anni Malmberg, Angela P. Moissl, Andrew P. Morris, Nikolaos Perakakis, Annette Peters, John R. Petrie, Michael Roden, Peter E.H. Schwarz, Sapna Sharma, Angela Silveira, Rona J. Strawbridge, Tiinamaija Tuomi, Andrew R. Wood, Peitao Wu, Björn Zethelius, Damiano Baldassarre, Johan G. Eriksson, Tove Fall, Jose C. Florez, Andreas Fritsche, Bruna Gigante, Anders Hamsten, Eero Kajantie, Markku Laakso, Jari Lahti, Deborah A. Lawlor, Lars Lind, Winfried März, James B. Meigs, Johan Sundström, Nicholas J. Timpson, Robert Wagner, Mark Walker, Nicholas J. Wareham, Hugh Watkins, Inês Barroso, Stephen O’Rahilly, Niels Grarup, Stephen CJ. Parker, Michael Boehnke, Claudia Langenberg, Eleanor Wheeler, Karen L. Mohlke
Publikováno v:
et al. 2023, ' Loci for insulin processing and secretion provide insight into type 2 diabetes risk ', American Journal of Human Genetics, vol. 110, no. 2, pp. 284-299 . https://doi.org/10.1016/j.ajhg.2023.01.002
Insulin secretion is critical for glucose homeostasis, and increased levels of the precursor proinsulin relative to insulin indicate pancreatic islet beta-cell stress and insufficient insulin secretory capacity in the setting of insulin resistance. W
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::55690bbb45193e18668a73f074e015dc
https://doi.org/10.1016/j.ajhg.2023.01.002
https://doi.org/10.1016/j.ajhg.2023.01.002