Zobrazeno 1 - 10
of 1 208
pro vyhledávání: '"Stephen, O'Rahilly"'
Autor:
John W. R. Kincaid, Debra Rimmington, John A. Tadross, Irene Cimino, Ilona Zvetkova, Arthur Kaser, Paul Richards, Satish Patel, Stephen O’Rahilly, Anthony P. Coll
Publikováno v:
Scientific Reports, Vol 14, Iss 1, Pp 1-13 (2024)
Abstract The hormone GDF15 is secreted in response to cellular stressors. Metformin elevates circulating levels of GDF15, an action important for the drug’s beneficial effects on body weight. Metformin can also inhibit mammalian respiratory complex
Externí odkaz:
https://doaj.org/article/36d415474a95447299258e0b0a1879b6
Autor:
Jake P Mann, Xiaowen Duan, Satish Patel, Luis Carlos Tábara, Fabio Scurria, Anna Alvarez-Guaita, Afreen Haider, Ineke Luijten, Matthew Page, Margherita Protasoni, Koini Lim, Sam Virtue, Stephen O'Rahilly, Martin Armstrong, Julien Prudent, Robert K Semple, David B Savage
Publikováno v:
eLife, Vol 12 (2023)
Mitochondrial dysfunction has been reported in obesity and insulin resistance, but primary genetic mitochondrial dysfunction is generally not associated with these, arguing against a straightforward causal relationship. A rare exception, recently ide
Externí odkaz:
https://doaj.org/article/10fcb30f48a744fd966e20290cf355fb
Autor:
Satish Patel, Afreen Haider, Anna Alvarez-Guaita, Guillaume Bidault, Julia Sarah El-Sayed Moustafa, Esther Guiu-Jurado, John A. Tadross, James Warner, James Harrison, Samuel Virtue, Fabio Scurria, Ilona Zvetkova, Matthias Blüher, Kerrin S. Small, Stephen O’Rahilly, David B. Savage
Publikováno v:
Molecular Metabolism, Vol 65, Iss , Pp 101589- (2022)
Objectives: Obesity in humans and mice is associated with elevated levels of two hormones responsive to cellular stress, namely GDF15 and FGF21. Over-expression of each of these is associated with weight loss and beneficial metabolic changes but wher
Externí odkaz:
https://doaj.org/article/86d575de029d49f1be5d61f2c525a70f
Autor:
O'Rahilly S
Publikováno v:
The Journal of clinical investigation [J Clin Invest] 2013 Jun; Vol. 123 (6), pp. 2335-6. Date of Electronic Publication: 2013 Jun 03.
Autor:
Irene Cimino, Debra Rimmington, Y. C. Loraine Tung, Katherine Lawler, Pierre Larraufie, Richard G. Kay, Samuel Virtue, Brian Y. H. Lam, Luca Fagnocchi, Marcella K. L. Ma, Vladimir Saudek, Ilona Zvetkova, Antonio Vidal-Puig, Giles S. H. Yeo, I. Sadaf Farooqi, J. Andrew Pospisilik, Fiona M. Gribble, Frank Reimann, Stephen O’Rahilly, Anthony P. Coll
Publikováno v:
Scientific Reports, Vol 11, Iss 1, Pp 1-15 (2021)
Abstract Neuronatin (Nnat) has previously been reported to be part of a network of imprinted genes downstream of the chromatin regulator Trim28. Disruption of Trim28 or of members of this network, including neuronatin, results in an unusual phenotype
Externí odkaz:
https://doaj.org/article/e7d5a888c2a540aeac4077803967b5d5
Autor:
Ushma S. Neill
Professor Stephen O’Rahilly’s research has led to an increased understanding of the genetic causes of human obesity and insulin resistance. Using modern biochemical approaches and classical clinical observation in humans with profound metabolic d
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::120c170e93be1eeb7f1d2af6dac5f944
https://europepmc.org/articles/PMC3668822/
https://europepmc.org/articles/PMC3668822/
Publikováno v:
Disease models & mechanisms [Dis Model Mech] 2010 Jul-Aug; Vol. 3 (7-8), pp. 402.
Autor:
Ming Yang, Tamana Darwish, Pierre Larraufie, Debra Rimmington, Irene Cimino, Deborah A. Goldspink, Benjamin Jenkins, Albert Koulman, Cheryl A. Brighton, Marcella Ma, Brian Y. H. Lam, Anthony P. Coll, Stephen O’Rahilly, Frank Reimann, Fiona M. Gribble
Publikováno v:
Scientific Reports, Vol 11, Iss 1, Pp 1-20 (2021)
Abstract Even though metformin is widely used to treat type2 diabetes, reducing glycaemia and body weight, the mechanisms of action are still elusive. Recent studies have identified the gastrointestinal tract as an important site of action. Here we u
Externí odkaz:
https://doaj.org/article/3277fbedd1ef4a0488a75dc21d27c7a7
Autor:
Richard N. Bergman
Publikováno v:
New England Journal of Medicine. 353:2201-2202
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::28a56331ba47131c3e18015972e27eac
https://doi.org/10.1056/nejm200511173532022
https://doi.org/10.1056/nejm200511173532022
Obesity is one of the most important contributing factors to disease throughout the world and is an area of great current interest among researchers and clinicians. The genetics of common obesity is complex, and an important thread through this labyr