Zobrazeno 1 - 10
of 34
pro vyhledávání: '"Stephen, Noell"'
Autor:
Britton Boras, Rhys M. Jones, Brandon J. Anson, Dan Arenson, Lisa Aschenbrenner, Malina A. Bakowski, Nathan Beutler, Joseph Binder, Emily Chen, Heather Eng, Holly Hammond, Jennifer Hammond, Robert E. Haupt, Robert Hoffman, Eugene P. Kadar, Rob Kania, Emi Kimoto, Melanie G. Kirkpatrick, Lorraine Lanyon, Emma K. Lendy, Jonathan R. Lillis, James Logue, Suman A. Luthra, Chunlong Ma, Stephen W. Mason, Marisa E. McGrath, Stephen Noell, R. Scott Obach, Matthew N. O’ Brien, Rebecca O’Connor, Kevin Ogilvie, Dafydd Owen, Martin Pettersson, Matthew R. Reese, Thomas F. Rogers, Romel Rosales, Michelle I. Rossulek, Jean G. Sathish, Norimitsu Shirai, Claire Steppan, Martyn Ticehurst, Lawrence W. Updyke, Stuart Weston, Yuao Zhu, Kris M. White, Adolfo García-Sastre, Jun Wang, Arnab K. Chatterjee, Andrew D. Mesecar, Matthew B. Frieman, Annaliesa S. Anderson, Charlotte Allerton
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-17 (2021)
The 3CL protease of SARS-CoV-2 is inhibited by PF-00835231 in vitro. Here, the authors show that the prodrug PF-07304814 has broad spectrum activity, inhibiting SARS-CoV and SARS-CoV-2 in mice and its ADME and safety profile support clinical developm
Externí odkaz:
https://doaj.org/article/7c0ac56767d64fb5af7714d7f3a62322
Autor:
Zachary Lee Johnson, Mark Ammirati, David Jonathan Wasilko, Jeanne S. Chang, Stephen Noell, Timothy L. Foley, Hyejin Yoon, Kathleen Smith, Shoh Asano, Katherine Hales, Min Wan, Qingyi Yang, Mary A. Piotrowski, Kathleen A. Farley, Tamara Gilbert, Lisa M. Aschenbrenner, Kimberly F. Fennell, Jason K. Dutra, Mary Xu, Chunyang Guo, Alison E. Varghese, Justin Bellenger, Alandra Quinn, Christopher W. am Ende, Graham M. West, Matthew C. Griffor, Donald Bennett, Matthew Calabrese, Claire M. Steppan, Seungil Han, Huixian Wu
Publikováno v:
Nature Structural & Molecular Biology. 30:22-30
Glycerol-3-phosphate acyltransferase (GPAT)1 is a mitochondrial outer membrane protein that catalyzes the first step of de novo glycerolipid biosynthesis. Hepatic expression of GPAT1 is linked to liver fat accumulation and the severity of nonalcoholi
Autor:
Nandini Chaturbhai Patel, Dafydd R. Owen, Rhonda D. Cardin, Karen J. Coffman, Jean G. Sathish, Devendra K. Rai, Heather Eng, Charlotte Moira Norfor Allerton, Jack C. Lee, Britton Boras, Melissa Avery, Qingyi Yang, Eugene P. Kadar, Anthony Carlo, Annaliesa S. Anderson, Matthew R. Reese, Li Di, Jisun Lee, Lisa Aschenbrenner, Stephen Noell, Lawrence W. Updyke, Martin Pettersson, Scott A. Gibson, Matthew F. Sammons, Al E. Stewart, Yuao Zhu, Alyssa Dantonio, Stephen W. Mason, Brett L. Hurst, Ketan S. Gajiwala, Claire M. Steppan, Liuqing Wei, Patrick Robert Verhoest, Samantha Elizabeth Greasley, Simon Berritt, R. Scott Obach, RoseAnn Ferre, Ravi Shankar P. Singh, Amit S. Kalgutkar, Jonathan J. Novak, Kevin Ogilvie, Wei Liu, Jamison B. Tuttle
Publikováno v:
Science. 374:1586-1593
Path to another drug against COVID-19 The rapid development of vaccines has been crucial in battling the ongoing COVID-19 pandemic. However, access challenges remain, breakthrough infections occur, and emerging variants present increased risk. Develo
Autor:
Dafydd R, Owen, Charlotte M N, Allerton, Annaliesa S, Anderson, Lisa, Aschenbrenner, Melissa, Avery, Simon, Berritt, Britton, Boras, Rhonda D, Cardin, Anthony, Carlo, Karen J, Coffman, Alyssa, Dantonio, Li, Di, Heather, Eng, RoseAnn, Ferre, Ketan S, Gajiwala, Scott A, Gibson, Samantha E, Greasley, Brett L, Hurst, Eugene P, Kadar, Amit S, Kalgutkar, Jack C, Lee, Jisun, Lee, Wei, Liu, Stephen W, Mason, Stephen, Noell, Jonathan J, Novak, R Scott, Obach, Kevin, Ogilvie, Nandini C, Patel, Martin, Pettersson, Devendra K, Rai, Matthew R, Reese, Matthew F, Sammons, Jean G, Sathish, Ravi Shankar P, Singh, Claire M, Steppan, Al E, Stewart, Jamison B, Tuttle, Lawrence, Updyke, Patrick R, Verhoest, Liuqing, Wei, Qingyi, Yang, Yuao, Zhu
Publikováno v:
Science (New York, N.Y.). 374(6575)
The worldwide outbreak of COVID-19 caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has become a global pandemic. Alongside vaccines, antiviral therapeutics are an important part of the healthcare response to countering the ongo
Autor:
Alyssa Dantonio, Heather Eng, Nandini Chaturbhai Patel, Anthony Carlo, Liuqing Wei, Annaliesa S. Anderson, Ravi Shankar P. Singh, Lawrence W. Updyke, Amit S. Kalgutkar, Jamison B. Tuttle, Lisa Aschenbrenner, Simon Berritt, Ketan S. Gajiwala, Jack C. Lee, Devendra K. Rai, Martin Pettersson, Matthew R. Reese, Jisun Lee, Stephen W. Mason, Eugene P. Kadar, RoseAnn Ferre, Melissa Avery, Li Di, Charlotte Moira Norfor Allerton, R. Scott Obach, Scott A. Gibson, Stephen Noell, Patrick Robert Verhoest, Kevin Ogilvie, Jonathan J. Novak, Brett L. Hurst, Dafydd R. Owen, Rhonda D. Cardin, Wei Liu, Yuao Zhu, Karen J. Coffman, Claire M. Steppan, Jean G. Sathish, Samantha Elizabeth Greasley, Matthew F. Sammons, Qingyi Yang, Britton Boras, Al E. Stewart
The worldwide outbreak of coronavirus disease 2019 (COVID-19) caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has become an established global pandemic. Alongside vaccines, antiviral therapeutics are an important part of the he
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::f0de6febfa535f3995194517e34278b9
https://doi.org/10.1101/2021.07.28.21261232
https://doi.org/10.1101/2021.07.28.21261232
Autor:
Claire M. Steppan, Hui Zhang, Lisa Aschenbrenner, Chang Liu, Lucien P. Ghislain, Lorraine F. Lanyon, Stephen Noell, Mike West, Jianhua Liu, Thomas R. Covey, Matthew D. Troutman, Kenneth J. DiRico, Wenyi Hua, Sammy S Datwani, Don W. Arnold
Publikováno v:
Analytical chemistry. 93(31)
We describe a mass spectrometry (MS) analytical platform resulting from the novel integration of acoustic droplet ejection (ADE) technology, an open-port interface (OPI), and electrospray ionization (ESI)-MS that creates a transformative system enabl
Autor:
Zdenek Berger, Sarah Perkins, Claude Ambroise, Christine Oborski, Matthew Calabrese, Stephen Noell, David Riddell, Warren D Hirst
Publikováno v:
PLoS ONE, Vol 10, Iss 3, p e0119141 (2015)
Mutations in glucocerebrosidase (GBA1) cause Gaucher disease and also represent a common risk factor for Parkinson's disease and Dementia with Lewy bodies. Recently, new tool molecules were described which can increase turnover of an artificial subst
Externí odkaz:
https://doaj.org/article/8f9a3b22faa94cbba6a4632a88d61010
Autor:
Samantha E. Greasley, Stephen Noell, Olga Plotnikova, RoseAnn Ferre, Wei Liu, Ben Bolanos, Kimberly Fennell, Jennifer Nicki, Tim Craig, Yuao Zhu, Al E. Stewart, Claire M. Steppan
Publikováno v:
Journal of Biological Chemistry. 298:101972
The COVID-19 pandemic continues to be a public health threat with emerging variants of SARS-CoV-2. Nirmatrelvir (PF-07321332) is a reversible, covalent inhibitor targeting the main protease (M
Autor:
Heather Eng, Annaliesa S. Anderson, Norimitsu Shirai, Brandon J. Anson, James Logue, Stuart Weston, Marisa McGrath, Martyn D. Ticehurst, Rebecca E. O’Connor, Michelle Rossulek, Martin Pettersson, Matthew N O' Brien, Jean G. Sathish, Matthew B. Frieman, Emi Kimoto, Jun Wang, R. Scott Obach, Emily I. Chen, Robert Haupt, Yuao Zhu, Thomas F. Rogers, Andrew D. Mesecar, Suman Luthra, Adolfo García-Sastre, Dafydd R. Owen, Rhys M. Jones, Eugene P. Kadar, Chunlong Ma, Rob Kania, Lisa Aschenbrenner, Arnab K. Chatterjee, Charlotte Moira Norfor Allerton, Joseph John Binder, Kevin Ogilvie, Holly L. Hammond, Nathan Beutler, Claire M. Steppan, Jennifer Hammond, Stephen Noell, Romel Rosales, Robert M. Hoffman, Lillis Jonathan Richard, Matthew R. Reese, Stephen W. Mason, Dan Arenson, Malina A. Bakowski, Lawrence W. Updyke, Lorraine F. Lanyon, Kris M. White, Emma K. Lendy, Melanie G. Kirkpatrick, Britton Boras
Publikováno v:
bioRxiv
Nature Communications, Vol 12, Iss 1, Pp 1-17 (2021)
Nature Communications, Vol 12, Iss 1, Pp 1-17 (2021)
COVID-19 caused by the SARS-CoV-2 virus has become a global pandemic. 3CL protease is a virally encoded protein that is essential across a broad spectrum of coronaviruses with no close human analogs. PF-00835231, a 3CL protease inhibitor, has exhibit
Autor:
Robert L. Hoffman, Robert S. Kania, Mary A. Brothers, Jay F. Davies, Rose A. Ferre, Ketan S. Gajiwala, Mingying He, Robert J. Hogan, Kirk Kozminski, Lilian Y. Li, Jonathan W. Lockner, Jihong Lou, Michelle T. Marra, Lennert J. Mitchell, Brion W. Murray, James A. Nieman, Stephen Noell, Simon P. Planken, Thomas Rowe, Kevin Ryan, George J. Smith, James E. Solowiej, Claire M. Steppan, Barbara Taggart
Publikováno v:
Journal of Medicinal Chemistry
The novel coronavirus disease COVID-19 that emerged in 2019 is caused by the virus SARS CoV-2 and named for its close genetic similarity to SARS CoV-1 that caused severe acute respiratory syndrome (SARS) in 2002. Both SARS coronavirus genomes encode