Zobrazeno 1 - 10
of 301
pro vyhledávání: '"Stephen, Chen"'
Autor:
Chun-Yan Wan, Yixin Yin, Xiaoyan Li, Meng Meng Liu, Graham Goldman, Li-An Wu, Feng Wang, Dao-Shu Luo, Zhuo Chen, Wen-An Xu, Stephen Chen, Mary MacDougall, Merry L. Lindsey, Zhi Chen, Shuo Chen
Publikováno v:
Genes and Diseases, Vol 11, Iss 5, Pp 101231- (2024)
Externí odkaz:
https://doaj.org/article/6930cc92928841879fcc19966b084033
Autor:
Zhefan Stephen Chen, Mingxi Ou, Stephanie Taylor, Ruxandra Dafinca, Shaohong Isaac Peng, Kevin Talbot, Ho Yin Edwin Chan
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-19 (2023)
Abstract The GGGGCC hexanucleotide repeat expansion mutation in the chromosome 9 open reading frame 72 (C9orf72) gene is a major genetic cause of amyotrophic lateral sclerosis and frontotemporal dementia (C9ALS/FTD). In this study, we demonstrate tha
Externí odkaz:
https://doaj.org/article/b3e750fa439f44bc949df9182694974b
Publikováno v:
Case Reports in Ophthalmology, Vol 14, Iss 1, Pp 692-697 (2023)
Introduction: We present a unique case of iris chafing syndrome in a patient with a complex ophthalmologic history after successful placement of a single-piece in-the-bag intraocular lens (IOL) in an eye with healthy zonular support. Case Presentatio
Externí odkaz:
https://doaj.org/article/305317dde8ae4ed49bb5694fde402717
Autor:
Shaohong Isaac Peng, Lok I. Leong, Jacquelyne Ka-Li Sun, Zhefan Stephen Chen, Hei-Man Chow, Ho Yin Edwin Chan
Publikováno v:
Molecular Therapy: Nucleic Acids, Vol 29, Iss , Pp 102-115 (2022)
Polyglutamine (polyQ) diseases, including spinocerebellar ataxias and Huntington’s disease, are progressive neurodegenerative disorders caused by CAG triplet-repeat expansion in the coding regions of disease-associated genes. In this study, we foun
Externí odkaz:
https://doaj.org/article/742fe03b25504f89bb4861cfdbe55b3d
Publikováno v:
GECONTEC: Revista Internacional de Gestión del Conocimiento y la Tecnología, Vol 3, Iss 1 (2022)
A multi-modal search space can be defined as having multiple attraction basins – each basin has a single local optimum which is reached from all points in that basin when greedy local search is used. Optimization in multi-modal search spaces can th
Externí odkaz:
https://doaj.org/article/b276b825b6324467bc51ccbd1cd4ab0e
Publikováno v:
GECONTEC: Revista Internacional de Gestión del Conocimiento y la Tecnología, Vol 2, Iss 3 (2022)
Computer modeling of protein ligand interactions is one of the most important phases in a drug design process. Part of the process involves the optimization of highly multi-modal objective (scoring) functions. This research presents the Minimum Popul
Externí odkaz:
https://doaj.org/article/a1a36f7581c24ea0aa44eecb3b179589
Publikováno v:
GECONTEC: Revista Internacional de Gestión del Conocimiento y la Tecnología, Vol 2, Iss 1 (2022)
El cómputo de alto rendimiento es una necesidad para el desarrollo de investigaciones con grandes volúmenes de datos. La creciente demanda de este tipo de resultados ha impulsado a varios centros de investigación a poner en funcionamiento recursos
Externí odkaz:
https://doaj.org/article/f2ac1b0747bd4bb5b241537c57dc675e
Autor:
Steve Bayer, Clarissa LeVasseur, Maria Munsch MD, Stephen Chen MD, Christopher D. Murawski MD, Conor I. Murphy MD, Dukens LaBaze MD, Alexandra Gabrielli MD, MS, Gillian Kane, William Anderst PhD, MaCalus V. Hogan MD, MBA, FAAOS, FAOA
Publikováno v:
Foot & Ankle Orthopaedics, Vol 7 (2022)
Category: Midfoot/Forefoot; Hindfoot Introduction/Purpose: Accurate characterization of foot type can facilitate identification of patients at risk for different foot disorders and direct operative treatment. Foot type can be determined qualitatively
Externí odkaz:
https://doaj.org/article/d4dba398c8e9444aad5161b3e7361150
Publikováno v:
Bioengineering, Vol 10, Iss 6, p 689 (2023)
Imaging of the ocular vasculature can provide new insights into the pathophysiology of ocular diseases. This study proposes a novel high-frequency super-resolution ultrasound localization microscopy (SRULM) technique and evaluates its ability to meas
Externí odkaz:
https://doaj.org/article/12fe2a1cf7594a37a9e136072bf11d7f
Publikováno v:
Cell Death and Disease, Vol 12, Iss 2, Pp 1-19 (2021)
Abstract Polyglutamine (polyQ) diseases comprise Huntington’s disease and several subtypes of spinocerebellar ataxia, including spinocerebellar ataxia type 3 (SCA3). The genomic expansion of coding CAG trinucleotide sequence in disease genes leads
Externí odkaz:
https://doaj.org/article/ce016e87a79b40d29b9c705bf2379d0c