Transkingdom interactions between Lactobacilli and hepatic mitochondria attenuate western diet-induced diabetes

Autor: Richard R. Rodrigues, Manoj Gurung, Zhipeng Li, Manuel García-Jaramillo, Renee Greer, Christopher Gaulke, Franziska Bauchinger, Hyekyoung You, Jacob W. Pederson, Stephany Vasquez-Perez, Kimberly D. White, Briana Frink, Benjamin Philmus, Donald B. Jump, Giorgio Trinchieri, David Berry, Thomas J. Sharpton, Amiran Dzutsev, Andrey Morgun, Natalia Shulzhenko

Publikováno v: Nature Communications, Vol 12, Iss 1, Pp 1-15 (2021)

Abstract Western diet (WD) is one of the major culprits of metabolic disease including type 2 diabetes (T2D) with gut microbiota playing an important role in modulating effects of the diet. Herein, we use a data-driven approach (Transkingdom Network

Externí odkaz: https://doaj.org/article/2d75b1d838834d4e88d47f7baca85691

Germ-Free Swiss Webster Mice on a High-Fat Diet Develop Obesity, Hyperglycemia, and Dyslipidemia

Autor: Isabelle E. Logan, Gerd Bobe, Cristobal L. Miranda, Stephany Vasquez-Perez, Jaewoo Choi, Malcolm B. Lowry, Thomas J. Sharpton, Andrey Morgun, Claudia S. Maier, Jan F. Stevens, Natalia Shulzhenko, Adrian F. Gombart

Publikováno v: Microorganisms, Vol 8, Iss 4, p 520 (2020)

A calorie-dense diet is a well-established risk factor for obesity and metabolic syndrome (MetS), whereas the role of the intestinal microbiota (IMB) in the development of diet-induced obesity (DIO) is not completely understood. To test the hypothesi

Externí odkaz: https://doaj.org/article/178af5bf71a84aa290ad54d28a43a9f7

CVID enteropathy is characterized by exceeding low mucosal IgA levels and interferon-driven inflammation possibly related to the presence of a pathobiont

Autor: Stanislav V. Sosnovtsev, Natalia Shulzhenko, Manoj Gurung, Michael Yao, Dariia Vyshenska, Xiaoxi Dong, Stephany Vasquez-Perez, Ivan J. Fuss, Ekaterina Peremyslova, Martha Quezado, Warren Strober, Kim Montgomery-Recht, Andrey Morgun, Renee L. Greer

Publikováno v: Clinical Immunology. 197:139-153

Common variable immunodeficiency (CVID), the most common symptomatic primary antibody deficiency, is accompanied in some patients by a duodenal inflammation and malabsorption syndrome known as CVID enteropathy (E-CVID). The goal of this study was to

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5881e2c9e08d12215f9d63a9cc2be84a
https://doi.org/10.1016/j.clim.2018.09.008

Germ-Free Swiss Webster Mice on a High-Fat Diet Develop Obesity, Hyperglycemia, and Dyslipidemia

Autor: Malcolm B. Lowry, Thomas J. Sharpton, Cristobal L. Miranda, Claudia S. Maier, Jan F. Stevens, Andrey Morgun, Adrian F. Gombart, Stephany Vasquez-Perez, Isabelle E. Logan, Natalia Shulzhenko, Gerd Bobe, Jaewoo Choi

Publikováno v: Microorganisms
Volume 8
Issue 4
Microorganisms, Vol 8, Iss 520, p 520 (2020)

A calorie-dense diet is a well-established risk factor for obesity and metabolic syndrome (MetS), whereas the role of the intestinal microbiota (IMB) in the development of diet-induced obesity (DIO) is not completely understood. To test the hypothesi

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f3f95702a9065efed02c7fdea439a168

Akkermansia muciniphila mediates negative effects of IFNγ on glucose metabolism

Autor: Ekaterina Peremyslova, Aleksandra E. Sikora, Stephany Vasquez-Perez, Xiaoxi Dong, Alexi A. Schoenborn, Gabriel Fernandes, Everton Padilha Gomes, Alexandre C. Pereira, Natalia Shulzhenko, Warren Strober, Gregory A. Taylor, Renee L. Greer, Andrey Morgun, Ajay S. Gulati, Ivan J. Fuss, Ana Carolina Franco de Moraes, Sandra Roberta Gouvea Ferreira, Ryszard A. Zielke, Michael Yao

Publikováno v: Nature Communications, Vol 7, Iss 1, Pp 1-13 (2016)
Nature Communications
Repositório Institucional da USP (Biblioteca Digital da Produção Intelectual)
Universidade de São Paulo (USP)
instacron:USP

Cross-talk between the gut microbiota and the host immune system regulates host metabolism, and its dysregulation can cause metabolic disease. Here, we show that the gut microbe Akkermansia muciniphila can mediate negative effects of IFNγ on glucose

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e09833a821730f6b358ac497d25f264d
https://pubmed.ncbi.nlm.nih.gov/27910881