Zobrazeno 1 - 10
of 42
pro vyhledávání: '"Stephanos Ioannidis"'
Autor:
E Josue Ruiz, Adan Pinto-Fernandez, Andrew P Turnbull, Linxiang Lan, Thomas M Charlton, Hannah C Scott, Andreas Damianou, George Vere, Eva M Riising, Clive Da Costa, Wojciech W Krajewski, David Guerin, Jeffrey D Kearns, Stephanos Ioannidis, Marie Katz, Crystal McKinnon, Jonathan O'Connell, Natalia Moncaut, Ian Rosewell, Emma Nye, Neil Jones, Claire Heride, Malte Gersch, Min Wu, Christopher J Dinsmore, Tim R Hammonds, Sunkyu Kim, David Komander, Sylvie Urbe, Michael J Clague, Benedikt M Kessler, Axel Behrens
Publikováno v:
eLife, Vol 10 (2021)
Lung squamous cell carcinoma (LSCC) is a considerable global health burden, with an incidence of over 600,000 cases per year. Treatment options are limited, and patient’s 5-year survival rate is less than 5%. The ubiquitin-specific protease 28 (USP
Externí odkaz:
https://doaj.org/article/eeea231092ca40e880a44f8ed5d20d8d
Autor:
Francis D. Gibbons, Stephen E. Fawell, Barry R. Davies, J. Paul Secrist, Michael Zinda, Martin Wild, Eric Gangl, Ricky W. Johnstone, Andrea Newbold, Gareth P. Gregory, Elizabeth A. Coker, Patricia Jaaks, Mathew J. Garnett, Alwin Schuller, Nancy Su, Omid Tavana, Areya Tabatabai, Jamal C. Saeh, William McCoull, Edward J. Hennessy, Stephanos Ioannidis, Thomas Gero, R. Bruce Diebold, Jeffrey Varnes, Shannon K. McWeeney, Stephen E. Kurtz, Jeffrey W. Tyner, Tristan Lubinski, Kathleen Burke, Deborah Lawson, Shenghua Wen, Terry Macintyre, Paula Lewis, Ammar Adam, Justin Cidado, Kate F. Byth, Steven W. Criscione, Srividya B. Balachander
Figure S6
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::444106ead769434517a6030981d594b4
https://doi.org/10.1158/1078-0432.22476393.v1
https://doi.org/10.1158/1078-0432.22476393.v1
Autor:
Francis D. Gibbons, Stephen E. Fawell, Barry R. Davies, J. Paul Secrist, Michael Zinda, Martin Wild, Eric Gangl, Ricky W. Johnstone, Andrea Newbold, Gareth P. Gregory, Elizabeth A. Coker, Patricia Jaaks, Mathew J. Garnett, Alwin Schuller, Nancy Su, Omid Tavana, Areya Tabatabai, Jamal C. Saeh, William McCoull, Edward J. Hennessy, Stephanos Ioannidis, Thomas Gero, R. Bruce Diebold, Jeffrey Varnes, Shannon K. McWeeney, Stephen E. Kurtz, Jeffrey W. Tyner, Tristan Lubinski, Kathleen Burke, Deborah Lawson, Shenghua Wen, Terry Macintyre, Paula Lewis, Ammar Adam, Justin Cidado, Kate F. Byth, Steven W. Criscione, Srividya B. Balachander
contains methods.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5f66d7cdc5a26035ed01be67bc7dad53
https://doi.org/10.1158/1078-0432.22476381.v1
https://doi.org/10.1158/1078-0432.22476381.v1
Autor:
Shenghua Wen, Srividya B. Balachander, Francis D. Gibbons, Michael Zinda, William McCoull, Nancy Su, Barry R. Davies, Stephen E. Kurtz, Terry MacIntyre, Edward J. Hennessy, Martin Wild, Paula Lewis, Ricky W. Johnstone, Jamal Carlos Saeh, Kathleen A. Burke, Omid Tavana, Andrea Newbold, Elizabeth A. Coker, Alwin Schuller, Justin Cidado, Diebold R Bruce, Tristan J. Lubinski, Steven Criscione, J. Paul Secrist, Kate Byth, Gareth P. Gregory, Deborah Lawson, Ammar Adam, Shannon K. McWeeney, Stephen Fawell, Thomas Gero, Jeffrey G. Varnes, Eric Gangl, Patricia Jaaks, Jeffrey W. Tyner, Mathew J. Garnett, Areya Tabatabai, Stephanos Ioannidis
Publikováno v:
Clinical Cancer Research. 26:6535-6549
Purpose: Targeting Bcl-2 family members upregulated in multiple cancers has emerged as an important area of cancer therapeutics. While venetoclax, a Bcl-2–selective inhibitor, has had success in the clinic, another family member, Bcl-xL, has also e
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::564420d79c6feacf9af617f03b6937bc
https://doi.org/10.1158/1078-0432.ccr-20-0863
https://doi.org/10.1158/1078-0432.ccr-20-0863
Autor:
Axel Behrens, Clive Da Costa, Min Wu, David Joseph Guerin, Emma Nye, Jonathan O'Connell, Adan Pinto-Fernandez, Eva M. Riising, Jeffrey D Kearns, Tim Hammonds, Andrew P. Turnbull, Crystal McKinnon, E. Josue Ruiz, Claire Heride, Christopher J. Dinsmore, Malte Gersch, Ian Rosewell, Thomas M. Charlton, Linxiang Lan, Neil P. Jones, Andreas Damianou, Hannah C. Scott, Benedikt M. Kessler, Sylvie Urbé, Michael J. Clague, Natalia Moncaut, Wojciech W. Krajewski, Stephanos Ioannidis, David Komander, Marie Katz, Sunkyu Kim, George Vere
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::205d91672bd258cadd1c178b2544807d
https://doi.org/10.7554/elife.71596.sa2
https://doi.org/10.7554/elife.71596.sa2
Autor:
Malte Gersch, Thomas M. Charlton, Michael J. Clague, Linxiang Lan, Hannah C. Scott, Sylvie Urbé, George Vere, Min Wu, Sunkyu Kim, Stephanos Ioannidis, Claire Heride, Jeffrey D Kearns, Jonathan O'Connell, David Komander, Adan Pinto-Fernandez, E. Josue Ruiz, Emma Nye, Axel Behrens, Benedikt M. Kessler, Andrew P. Turnbull, Marie Katz, Natalia Moncaut, Andreas Damianou, Wojciech W. Krajewski, Neil P. Jones, Christopher J. Dinsmore, Ian Rosewell, Tim Hammonds, David Joseph Guerin, Eva M. Riising, Crystal McKinnon, Clive Da Costa
Publikováno v:
eLife, Vol 10 (2021)
eLife
eLife
Lung squamous cell carcinoma (LSCC) is a considerable global health burden, with an incidence of over 600,000 cases per year. Treatment options are limited, and patient’s 5-year survival rate is less than 5%. The ubiquitin-specific protease 28 (USP
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::beb8f4f7baf6b379b1145b3efa1b3fa6
https://elifesciences.org/articles/71596
https://elifesciences.org/articles/71596
Autor:
Weiping Wang, Adan Pinto-Fernandez, Caravella Justin Andrew, Stephanos Ioannidis, Claire Heride, Benedikt M. Kessler, David Komander, Michael J. Clague, Simon J. Davis, Marie Katz, Victoria Smith, Hannah Elcocks, Tim Hammonds, Andreas Kallinos, Sylvie Urbé, Bruce Follows, Christopher J. Dinsmore, Sunkyu Kim, Katherine J. Kayser-Bricker, Steven Mischke, Shawn Fessler, Anne Clancy, Neil P. Jones, Axel Behrens, Jonathan O'Connell, Crystal McKinnon
Publikováno v:
The Journal of Cell Biology
When a ribosome stalls during translation, it runs the risk of collision with a trailing ribosome. Such an encounter leads to the formation of a stable di-ribosome complex, which needs to be resolved by a dedicated machinery. The initial stalling and
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e018963cdf960a0fdc0658ee368510ab
http://europepmc.org/articles/PMC7888347
http://europepmc.org/articles/PMC7888347
Autor:
Weiping Wang, Adan Pinto-Fernandez, Simon J. Davis, Katherine J. Kayser-Bricker, Victoria Smith, Jonathan O'Connell, Christopher J. Dinsmore, Crystal McKinnon, Neil P. Jones, Bruce Follows, Marie Katz, Claire Heride, Sylvie Urbé, Anne Clancy, Benedikt M. Kessler, Andreas Kallinos, Sunkyu Kim, Axel Behrens, Steven Mischke, Stephanos Ioannidis, Shawn Fessler, David Komander, Caravella Justin Andrew, Tim Hammonds, Hannah Elcocks, Michael J. Clague
Publikováno v:
The Journal of Cell Biology
Bioxriv
Bioxriv
Clancy et al. develop a specific chemical inhibitor of USP9X and characterize its effects upon the cellular proteome. This analysis reveals a central role in the regulation of ribosomal stalling through control of critical E3 ligases.
When a rib
When a rib
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::be84b6d5732fc90b5778aeba316a4c43
https://doi.org/10.1083/jcb.202004211
https://doi.org/10.1083/jcb.202004211
Autor:
Aitor Martinez, Franziska Guenther, Benedikt M. Kessler, Katherine S. England, Elena Marcassa, Malte Gersch, Simon J. Davis, Alejandro Murad, Katherine J. Kayser-Bricker, Frederic Lamoliatte, Andreas Kallinos, Jane Jardine, Sylvie Urbé, Stephanos Ioannidis, Akshada Gajbhiye, Francesco G. Barone, Mariacarmela Giurrandino, Hannah C. Scott, Christopher J. Burke, Katy McCarron, David Komander, Emma J. Murphy, Alexandre J. Buckmelter, Matthias Trost, Michael K. Ahlijanian, Adan Pinto-Fernandez, Emma V Rusilowicz-Jones, Heather Mortiboys, Michael J. Clague
Publikováno v:
LIFE SCIENCE ALLIANCE
Life Science Alliance
Life Science Alliance
A new inhibitor of the deubiquitylase USP30, an actionable target relevant to Parkinson’s Disease, is introduced and characterised for parameters related to mitophagy.
The mitochondrial deubiquitylase USP30 negatively regulates the selective a
The mitochondrial deubiquitylase USP30 negatively regulates the selective a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::eb623ed1d21051d2610b1c0e5b7d95ea
http://livrepository.liverpool.ac.uk/3093573/1/LSA-2020-00768-TRR_Merged_PDF.pdf
http://livrepository.liverpool.ac.uk/3093573/1/LSA-2020-00768-TRR_Merged_PDF.pdf
Autor:
David M. Bolduc, Nicholas A. Larsen, Stephanos Ioannidis, Federico Colombo, Toung-Vi Nguyen, Frédéric H. Vaillancourt, Alan Rolfe, Lihua Yu, Ping Zhu, Andrew Cook, Milena Virrankoski, Reynolds Dominic, Kiyoyuki Omoto, Shihua Yao
Publikováno v:
ACS Med Chem Lett
[Image: see text] Carbamoyl phosphate synthetase 1 (CPS1) is a potential synthetic lethal target in LKB1-deficient nonsmall cell lung cancer, where its overexpression supports the production of pyrimidine synthesis. In other cancer types, CPS1 overex
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e65eb58d3e5de871c2ef8af973dc3067
https://europepmc.org/articles/PMC7294722/
https://europepmc.org/articles/PMC7294722/