Zobrazeno 1 - 7
of 7
pro vyhledávání: '"Stephanie Y. Leonard"'
Autor:
Juliann Chmielecki, Stephanie Y. Leonard, Michael L. Kendrick, Kai Wang, Michael R. Bardsley, Sabriya A. Syed, Chih Min Tang, Jonathan C. Chan, Olivier Harismendy, Deborah Morosini, Martina De Siena, Jeffrey S. Ross, Adam M. Burgoyne, Fei Gao, Tamas Ordog, Jason K. Sicklick, Junhao Mao, Eileen Shi, Tracy E. Lee
Publikováno v:
Oncotarget
Gastrointestinal stromal tumors (GIST) arise within the interstitial cell of Cajal (ICC) lineage due to activating KIT/PDGFRA mutations. Both ICC and GIST possess primary cilia (PC), which coordinate PDGFRA and Hedgehog signaling, regulators of gastr
Autor:
Stephanie Y. Leonard, Chih-Min Tang, Carl K. Hoh, Jason K. Sicklick, Richard Schwab, Michele L. Babicky, Randall French, Dawn Jaquish, Evangeline Mose, Michael R. Peterson, Andrew M. Lowy
Publikováno v:
Journal of translational medicine, vol 12, iss 1
Journal of Translational Medicine
Journal of Translational Medicine
Background Gastrointestinal stromal tumor (GIST) is the most common sarcoma and its treatment with imatinib has served as the paradigm for developing targeted anti-cancer therapies. Despite this success, imatinib-resistance has emerged as a major pro
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f5881ccbbff108d594f7295d6a5d7418
https://escholarship.org/uc/item/7329m6hg
https://escholarship.org/uc/item/7329m6hg
Autor:
Michael Bouvet, Stephanie Y. Leonard, Hop S. Tran Cao, Chih Min Tang, Jason K. Sicklick, Sharmeela Kaushal, Paolo Magistri, Robert M. Hoffman, Cristina A. Metildi
Publikováno v:
Annals of surgical oncology, vol 20 Suppl 3, iss 0 3
BackgroundGastrointestinal stromal tumors (GISTs) are frequently characterized by KIT overexpression. Tumor-free margins and complete cytoreduction of disease are mainstays of treatment. We hypothesized that fluorescently labeled anti-KIT antibodies
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e3d2870edbe14a92430781258a537251
https://europepmc.org/articles/PMC4127988/
https://europepmc.org/articles/PMC4127988/
Autor:
Stephanie Y. Leonard, Chih-Min Tang, Paolo Magistri, Tracy E. Lee, Jonathan C. Chan, Jason K. Sicklick
Publikováno v:
The Journal of surgical research. 187(2)
Background Hepatocellular carcinoma (HCC) frequently represents two diseases as it often arises in the setting of cirrhosis caused by the proliferation and activation of hepatic stellate cells (HSCs). Previously, we identified that Hedgehog (Hh) sign
Autor:
Jason K. Sicklick, Michael Bouvet, Cristina A. Metildi, Chih-Min Tang, Stephanie Y. Leonard, Paolo Magistri, Sharmeela Kaushal, Robert M. Hoffman
Publikováno v:
Cancer Research. 73:731-731
Gastrointestinal stromal tumor (GIST), the most common sarcoma, metastasizes hematogenously and peritoneally. Tumor-free margins and complete cytoreduction of metastatic disease are critical for decreasing recurrence. Since most GISTs overexpress KIT
Publikováno v:
Journal of Surgical Research. 172:308
Autor:
Stephanie Y. Leonard, Michele Criscuoli, Karly Maruyama, Andrew M. Lowy, Richard Schwab, Randall French, Jason K. Sicklick, David A. Cheresh, Evangeline Mose, Dawn Jaquish
Publikováno v:
Journal of Clinical Oncology. 30:202-202
202 Background: GIST treatment with imatinib has served as the prototype for targeted molecular therapy. However, patients frequently acquire drug resistance to imatinib and this has prompted the development of additional multi-kinase inhibitors. To