Integrated T cell cytometry metrics for immune-monitoring applications in immunotherapy clinical trials

Autor: Dimitrios N. Sidiropoulos, Genevieve L. Stein-O’Brien, Ludmila Danilova, Nicole E. Gross, Soren Charmsaz, Stephanie Xavier, James Leatherman, Hao Wang, Mark Yarchoan, Elizabeth M. Jaffee, Elana J. Fertig, Won Jin Ho

Publikováno v: JCI Insight, Vol 7, Iss 19 (2022)

Mass cytometry, or cytometry by TOF (CyTOF), provides a robust means of determining protein-level measurements of more than 40 markers simultaneously. While the functional states of immune cells occur along continuous phenotypic transitions, cytometr

Externí odkaz: https://doaj.org/article/16cb3e58e1f7450682ee64a8668cb44a

Profiling of syngeneic mouse HCC tumor models as a framework to understand anti–PD-1 sensitive tumor microenvironments

Autor: Daniel J. Zabransky, Ludmila Danilova, James M. Leatherman, Tamara Y. Lopez‐Vidal, Jessica Sanchez, Soren Charmsaz, Nicole E. Gross, Sarah Shin, Xuan Yuan, Alexei Hernandez, Hongqui Yang, Stephanie Xavier, Daniel Shu, Ali Saeed, Kabeer Munjal, Zeal Kamdar, Luciane T. Kagohara, Elizabeth M. Jaffee, Mark Yarchoan, Won Jin Ho

Publikováno v: Hepatology

BACKGROUND AND AIMS: The treatment of hepatocellular carcinoma (HCC) has been transformed by the use of immune checkpoint inhibitors. However, most patients with HCC do not benefit from treatment with immunotherapy. There is an urgent need to underst

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fb8d8e5bded14d7bc88afdbe64239061
https://europepmc.org/articles/PMC9905363/

ATUAÇÃO INTERDISCIPLINAR NA ATENÇÃO À MULHER: FACILIDADES E DIFICULDADES NA ASSISTÊNCIA

Autor: Beatriz Pereira Alves, Alberto Fellipe Santana de Farias, Danilo Augusto de Holanda Ferreira, Maiara Millian da Silva Rocha, Beatriz Macedo da Silva Gomes, Jéssica Mendes Vale, Maria Diane Braga Dantas Monteiro, Amanda Haissa Barros Henriques, Camila Nascimento Oliveira, Nattalia Reis de Mesquita, Davidson Cruz de Oliveira Dantas, Dandara Miranda Souza, Rayllane Santos Nunes, Maria Clara Nascimento Estrela, Maria Berenice Gomes Nascimento, Alana Kelly Maia Macedo Nobre de Lima, Mario Hélio Antunes Pamplona, Sheila Milena Pessoa dos Santos, Kozete Hannah Nóbrega Cândido, Rogéria Mônica Seixas Xavier de Abreu, Roberson Matteus Fernandes Silva, Laurita da Silva Cartaxo, Ana Beatriz Linhares Rodrigues, Camila Cíntia Abreu Santana, Isabelle Rodrigues Bessa Silva, Ankilma do Nascimento Andrade Feitosa, Pedro Tiago Campos Mota Nunes, Nithalma Chelly Maia Macedo Nobre de Castro, Geilson Xavier de Azevedo Junior, Samara Miranda Leite, Rosielly Cruz de Oliveira Dantas, Jessika Lopes Figueiredo Pereira Batista, Cecília Danielle Bezerra Oliveira, Mayara Evangelista de Andrade, Mércia de França Nóbrega, Lucilla Vieira Carneiro, CicerlandiaNascimento Ferreira Xavier, Fabricia Alves de Souza, Maria Yadja de Oliveira Batista, Francisca Brigyda Alves Pereira, Isadora Priscila de Oliveira Sizenando, Amanda Pinheiro de Alencar, Rita de Cassia Cordeiro de Oliveira, Anubes Pereira de Castro, Marilena Maria de Sousa, Cícero Glenderson Alves Pereira de Lima, Amanda Mayara de Sousa Silva, Alcimar Tamir Vieira da Silva, Juliana Santos de Sousa, Ayanne Mirelle de Sousa Silva, Stefany Gomes Machado, Francisco Eduardo Ferreira Alves, Chiara Ster Moreira Falcão, Ana Carolina Araújo de Queiroga Lima, Jamille Rodriges Dias Cruz, Luiza Maria Alfredo da Silva, Alba Rejane Gomes de Moura Rodrigues, Francisca das Chagas Soares Pereira, Rebeca Rodrigues da Silva, Raimundo Dantas do Nascimento Netto, Josefa Fernanda Dantas Silva, Sarah Gitana Ferreira Pessoa, Joaquim Henrique Alves Amorim, Ianca Alves de Oliveira, Rodrigo Marcelino Zacarias de Andrade, Isabela de Paula Nunes, Luana Maria Morais Vieira, Mateus Gonçalves Rolim, Gabriella Augusta de Paiva Oliveira, Roumayne Fernandes Vieira de Andrade, Poliana Leite Neiva, Francisco Leite Rolim Neto, Vitória Moura Rodrigues Veiga, Larissa Rodrigues Oliveira, Lucas Nunes Duarte Medeiros, Evilly Rolim de Lima, Gabriella Stephanie Xavier de Brito, Alanne Renaly Mota Rodrigues, Joyce Honório de Queiroga, Symara Abrantes Albuquerque de Oliveira Cabral, Alana Cândido Paulo, Thyago Leite Campos de Araújo, Maria Luiza de Lima Pereira Dias, Fernanda Mísia Menezes Alves, Monnizia Pereira Nóbrega, Patrícia Michele Roque da Silva, Betânia Maria Oliveira de Amorim, Maria Luiza de Oliveira Ferreira Lima, Hyale Maria Nunes Silva, Thiozano Afonso de Carvalho, Rosicleide Rúbia Pereira Medeiros, Magna Jaíne Alves de Brito, Jéssica Alves do Nascimento, Aissa Romina Silva do Nascimento, Lara Bianca Soares Brandão, Thaís Santos Andrade, Juliana Sabino de Oliveira, Iara Maria Oliveira de Carvalho, Dionéa Ferreira Ayres Viana, Rosimery Cruz de Oliveira Dantas, Nayoby Kelly Bezerra Costa, Valéria Alves da Silva, Gedson Nogueira Santos, Kevia Katiucia Santos Bezerra, Maria Angélica de Sousa Lima, Helena Feitoza de Oliveira Alves, Maiara Bezerra Dantas, Pamela Tereza de Oliveira Gomes, Mikaella Thalita da Silva Matias, Esdras Ferreira Albuquerque, Maria Cecília Dantas de Aquino, Thalita Regina Morais dos Santos

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::3ba518f29704cdf3afa7f4d589911a97
https://doi.org/10.29327/540615

Abstract 1970: Single cell proteomic quantification of T cell states using mass cytometry for applications in monitoring immune responses in cancer immunotherapy clinical trials

Autor: Dimitrios N. Sidiropoulos, Zaw Phyo, Nicole Gross, Soren Charmsaz, Stephanie Xavier, James Leatherman, Mark Yarchoan, Elizabeth M. Jaffee, Elana J. Fertig, Won Jin Ho

Publikováno v: Cancer Research. 82:1970-1970

Although immunotherapies have been established as a successful treatment option for several types of cancers, additional treatment strategies are necessary to broaden the cohorts of patients who may receive clinical benefit. Common immunological prof

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::e75de36825050d013aa3611348987495
https://doi.org/10.1158/1538-7445.am2022-1970

Viral status, immune microenvironment and immunological response to checkpoint inhibitors in hepatocellular carcinoma

Autor: Ludmila Danilova, Elana J. Fertig, Won Jin Ho, Elizabeth M. Jaffee, Rohan X. Verma, Marcelo B. Sztein, James M. Leatherman, Mark Yarchoan, Stephanie Xavier, Hao Wang, Su Jin Lim

Publikováno v: Journal for ImmunoTherapy of Cancer, Vol 8, Iss 1 (2020)
Journal for Immunotherapy of Cancer

Background and aimsImmune checkpoint inhibitors (ICIs) targeting the programmed cell death protein 1 (PD-1)/programmed death-ligand 1 (PD-L1) pathway have clinical activity in hepatocellular carcinoma (HCC), but only a subset of patients respond to t

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bbfa2396255a4a21fbcdd21c23d40e2e
https://jitc.bmj.com/content/8/1/e000394.full