Zobrazeno 1 - 10
of 11
pro vyhledávání: '"Stephanie Whitman"'
Autor:
Eric Oh, Stephanie Whitman, Robert A. Goldbeck, Chris D. Vulpe, Alisha M. Thompson, Kaushik Ghosh, Zhu Zhiwu, Theodore R. Holman, Xiaoli Shi
Publikováno v:
Biochemistry. 44:16729-16736
Yeast damage-associated response protein (Dap1p) and mouse progesterone receptor membrane component-1 protein (mPGRMC1p) belong to a highly conserved class of putative membrane-associated progesterone binding proteins (MAPR), with Dap1p and inner zon
Publikováno v:
The Prostate. 64:128-138
BACKGROUND. Prostate cancer (PCa) is the leading cancer related death in America. Gleasongradingiscurrentlythepredominantmethodforprediction,withonlyfewbiomarkers available. More biomarkers, especially as they relate to cancer progression are desirab
Autor:
Joanne F. Arguello, Robert H. Cichewicz, Victor Kenyon, Nancy M. Morales, Theodore R. Holman, Phillip Crews, Stephanie Whitman
Publikováno v:
Journal of the American Chemical Society. 126:14910-14920
The selective inhibition of human 15-lipoxygenase (15-hLO) could serve as a promising therapeutic target for the prevention of atherosclerosis. A screening of marine sponges revealed that crude extracts of Psammocinia sp. exhibited potent 15-hLO inhi
Autor:
Theodore R Holman, Ilya Chorny, Stephanie Whitman, Victor Kenyon, Noah Perrin, Matthew P. Jacobson, Claude F. Bernasconi, Rakesh Mogul, Viola Ruddat, Cameron Chen
Publikováno v:
Biochemistry. 43:13063-13071
There is much debate whether the fatty acid substrate of lipoxygenase binds "carboxylate-end first" or "methyl-end first" in the active site of soybean lipoxygenase-1 (sLO-1). To address this issue, we investigated the sLO-1 mutants Trp500Leu, Trp500
Publikováno v:
Biochemistry. 42:4172-4178
Herein, we report on the role of the allosteric site in the activation mechanism of soybean lipoxygenase-1 utilizing stopped-flow inhibition kinetic studies. The K(D) for the activation was determined to be 25.9 +/- 2.3 microM and the rate constant f
Publikováno v:
Journal of Medicinal Chemistry. 45:2659-2661
Lipoxygenase (LO) is a biological target for many diseases such as asthma, atherosclerosis, and cancer. Our labs have synthesized and investigated nordihydroguaiaretic acid (NDGA) derivatives and have established that the reductive inhibition of soyb
Autor:
Theodore R. Holman, Joshua D. Deschamps, Stephanie Whitman, Jeffrey T. Gautschi, Phillip Crews, Tyler A. Johnson, Nadine C. Gassner
Human lipoxygenases (hLO) have been implicated in a variety of diseases and cancers and each hLO isozyme appears to have distinct roles in cellular biology. This fact emphasizes the need for discovering selective hLO inhibitors for both understanding
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1968d946091eaf4485081907467fd947
https://europepmc.org/articles/PMC2203963/
https://europepmc.org/articles/PMC2203963/
Publikováno v:
Journal of natural products. 67(8)
Two new phakellin alkaloids, (-)-7-N-methyldibromophakellin (14) and (-)-7-N-methylmonobromophakellin (15), were isolated from an Agelas sp. sponge, collected near Wewak, Papua New Guinea. Inhibition assays employing both 12- and 15-human lipoxygenas
Autor:
Theodore R. Holman, Chad C. Stessman, Jon Clardy, Phillip Crews, Christopher P. Loo, Tyler A. Johnson, Emil B. Lobkovsky, Stephanie Whitman, Taro Amagata
Publikováno v:
Journal of natural products. 66(2)
To sharpen the search for new lipoxygenase inhibitors, we designed a screen to probe for both potency and selectivity. The assay utilized 12-human (12-HLO), 15-human (15-HLO), and 15-soybean (15-SLO) lipoxygenases. The IC(50) value data obtained prov
Autor:
Arvinder Sran, Hector M. Rodriguez, Yonghong Song, Johan D. Oslob, Raja Kawas, Stephanie Whitman-Cox
Publikováno v:
Biophysical Journal. 106:562a
We have identified a small molecule inhibitor, MYK0000461, of the cardiac myosin ATPase. This agent was characterized in steady state and transient kinetic assays to understand its mechanism of action. MYK0000461 decreases the steady-state rate of th