Zobrazeno 1 - 10
of 28
pro vyhledávání: '"Stephanie Weng"'
Autor:
Gang Lu, Stephanie Weng, Mary Matyskiela, Xinde Zheng, Wei Fang, Scott Wood, Christine Surka, Reina Mizukoshi, Chin-Chun Lu, Derek Mendy, In Sock Jang, Kai Wang, Mathieu Marella, Suzana Couto, Brian Cathers, James Carmichael, Philip Chamberlain, Mark Rolfe
Publikováno v:
eLife, Vol 7 (2018)
The cereblon modulating agents (CMs) including lenalidomide, pomalidomide and CC-220 repurpose the Cul4-RBX1-DDB1-CRBN (CRL4CRBN) E3 ubiquitin ligase complex to induce the degradation of specific neomorphic substrates via polyubiquitination in conjun
Externí odkaz:
https://doaj.org/article/8ea06e542c9e4cde89d15b97eac42be1
Autor:
Arianna Silva-Torres, Scott Wood, Mark Rolfe, Gang Lu, Reina Mizukoshi, In Sock Jang, Stephanie Weng, Shawn Namiranian, Zhongying Mo, Michelle Slade, Celia Fontanillo, Joshua M. Baughman, Kai Wang, Marwa Khater
Publikováno v:
Blood Adv
CC-122 is a next-generation cereblon E3 ligase–modulating agent that has demonstrated promising clinical efficacy in patients with relapsed or refractory diffuse large B-cell lymphoma (R/R DLBCL). Mechanistically, CC-122 induces the degradation of
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::aa23ee100329e6160d428dd48b86c82c
https://europepmc.org/articles/PMC8045513/
https://europepmc.org/articles/PMC8045513/
Autor:
Russell Dekelver, Katherine Tin Heng Liu, Amanda G Davis, Su Xian, Dong-Er Zhang, Elizabeth T Andrews, Ming Yan, Mengdan Liu, Samuel A Stoner, Hannah Carter, Kei-ichiro Arimoto, Stephanie Weng, Michelle Dow
Publikováno v:
Blood Cancer Journal
Blood Cancer Journal, Vol 10, Iss 2, Pp 1-14 (2020)
Blood cancer journal, vol 10, iss 2
Blood Cancer Journal, Vol 10, Iss 2, Pp 1-14 (2020)
Blood cancer journal, vol 10, iss 2
Large-scale chromosomal translocations are frequent oncogenic drivers in acute myeloid leukemia (AML). These translocations often occur in critical transcriptional/epigenetic regulators and contribute to malignant cell growth through alteration of no
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::52b10738adad210f89f3bb6050c60d80
http://europepmc.org/articles/PMC7005177
http://europepmc.org/articles/PMC7005177
Publikováno v:
The Journal of the Michigan Dental Association. 99(3)
Vascular calcification occurs with aging, and several risk factors including diabetes, hyperlipidemia, and disorders of calcium metabolism have been identified. M6nckeberg medial sclerosis (MMS) is the most common variant of medial calcification. M6n
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::5263a32971cc16a40fae3e74fe40ab6d
https://pubmed.ncbi.nlm.nih.gov/30398796
https://pubmed.ncbi.nlm.nih.gov/30398796
Autor:
Wei Fang, Kai Wang, Gang Lu, Philip P Chamberlain, Chin-Chun Lu, Xinde Zheng, Brian E. Cathers, Mathieu Marella, Derek Mendy, Scott Wood, Christine Surka, Suzana Couto, Mary E Matyskiela, James Carmichael, Mark Rolfe, Stephanie Weng, In Sock Jang, Reina Mizukoshi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::1821c4829908ea14c4c4f46fe02bc003
https://doi.org/10.7554/elife.40958.033
https://doi.org/10.7554/elife.40958.033
Autor:
Stephanie Weng, In Sock Jang, Brian E. Cathers, James Carmichael, Kai Wang, Mark Rolfe, Chin-Chun Lu, Xinde Zheng, Reina Mizukoshi, Gang Lu, Scott Wood, Suzana Couto, Mary E Matyskiela, Christine Surka, Derek Mendy, Philip P Chamberlain, Wei Fang, Mathieu Marella
Publikováno v:
eLife, Vol 7 (2018)
eLife
eLife
The cereblon modulating agents (CMs) including lenalidomide, pomalidomide and CC-220 repurpose the Cul4-RBX1-DDB1-CRBN (CRL4CRBN) E3 ubiquitin ligase complex to induce the degradation of specific neomorphic substrates via polyubiquitination in conjun
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d1043d3c356ed168936163aee9a94f51
https://elifesciences.org/articles/40958
https://elifesciences.org/articles/40958
Autor:
Miao Chia Lo, Dan Ran, Dong-Er Zhang, Cody T. Mowery, Stephanie Weng, Samuel A Stoner, Kentson Lam, Amanda G Davis, Shinobu Matsuura
Publikováno v:
Leukemia, vol 31, iss 1
Leukemia
Leukemia
Granulocyte macrophage-colony-stimulating factor (GM-CSF) signaling regulates hematopoiesis and immune responses. CSF2RA, the gene encoding the α-subunit for GM-CSF, is significantly downregulated in t(8;21) (RUNX1-ETO or RE) leukemia patients, sugg
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b100d6311b2a3c463663a21888fb53bc
https://escholarship.org/uc/item/3pz4h75w
https://escholarship.org/uc/item/3pz4h75w
Publikováno v:
Cell Cycle. 9:3479-3484
Cells are highly responsive to their environment. One of the main strategies used by cells in signal transduction is protein phosphorylation, a reversible modification that regulates numerous biological processes. Misregulation of phosphorylation-med
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::465a362a4f3ca08648040e60626614d5
https://doi.org/10.4161/cc.9.17.13152
https://doi.org/10.4161/cc.9.17.13152
Publikováno v:
Receptors & Clinical Investigation.
The oncogenic role of EGFR in many tumors has attracted a great deal of attention in the recent years and initiated the development of several potent EGFR inhibitors, which are used clinically for cancer treatment. However, the current therapeutic in
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d63f7b450c4db70d4b061f46c144f987
https://doi.org/10.14800/rci.485
https://doi.org/10.14800/rci.485
Publikováno v:
Molecular and cellular biology, vol 34, iss 20
Epidermal growth factor (EGF) receptor (EGFR) has been implicated in tumor development and invasion. Dimerization and autophosphorylation of EGFR are the critical events for EGFR activation. However, the regulation of EGF-dependent and EGF-independen
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a7c653a8d775f6c7b44013f196dcb2b6
https://europepmc.org/articles/PMC4187709/
https://europepmc.org/articles/PMC4187709/