Výsledky vyhledávání - "Stephanie Webber"

Citizen science chlorine surveillance during the Flint, Michigan federal water emergency

Autor: Victoria Webber, Stephanie Webber, Keri Webber, Matthew Mosteller, LeeAnne Walters, Kaylie Mosteller, Lola Reid, Marc Edwards, Siddhartha Roy

Publikováno v: Water Research. 201:117304

Rising incidence of waterborne diseases including Legionellosis linked to low chlorine residuals in buildings and the availability of inexpensive testing options, create an opportunity for citizen science chorine monitoring to complement sampling don

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8dbef5224c517d0df305cd5a35e4c58f
https://doi.org/10.1016/j.watres.2021.117304

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The development of bioresorbable composite polymeric implants with high mechanical strength

Autor: Rany Busold, Upma Sharma, Greg Zugates, Danny Concagh, Robert Langer, Jonathan Merlo, Changcheng You, Stephanie Webber, Yina Kuang, Quynh Pham, Lee Core, George M. Whitesides, Maria Palasis

Publikováno v: Nature materials. 17(1)

Implants for the treatment of tissue defects should mimic the mechanical properties of the native tissue of interest and should be resorbable as well as biocompatible. In this work, we developed a scaffold from variants of poly(glycolic) acid which w

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::82dfca65c69e16b9a1e49def2b9e3faa
https://pubmed.ncbi.nlm.nih.gov/29180778

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Lack of Respiratory and Contact Sensitizing Potential of the Intranasal Antiviral Drug Candidate Rupintrivir (AG7088): A Weight-of-the-Evidence Evaluation

Autor: Leigh Ann Burns-Naas, Stephanie Webber, Mark Zorbas, Caroline A. Lee, Winston Evering, Lisa Ahern

Publikováno v: Journal of Immunotoxicology. 2:123-139

Rupintrivir, also known as AG7088, is a small molecule 3C protease inhibitor designed to target human rhinovirus as a potential intranasal treatment for the common cold. The ability of rupintrivir to induce both respiratory and contact hypersensitivi

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8ca31bb5ca2bb71a0db895996d8d5fae
https://doi.org/10.1080/15476910500203925

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Tripeptide Aldehyde Inhibitors of Human Rhinovirus 3C Protease: Design, Synthesis, Biological Evaluation, and Cocrystal Structure Solution of P1 Glutamine Isosteric Replacements

Autor: J W Meador rd, K. Okano, Rose Ann Ferre, Edward L. Brown, Y Xin, Stephanie Webber, Susan L. Binford, Stephen T. Worland, Shella A. Fuhrman, R. A. Love, David A. Matthews, Clifford E. Ford, Amy K. Patick, Thomas F. Hendrickson, T L Little, Reich Siegfried Heinz

Publikováno v: Journal of Medicinal Chemistry. 41:2786-2805

The investigation of tripeptide aldehydes as reversible covalent inhibitors of human rhinovirus (HRV) 3C protease (3CP) is reported. Molecular models based on the apo crystal structure of HRV-14 3CP and other trypsin-like serine proteases were constr

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8c98daa2461fe174d5e29e09d48754a4
https://doi.org/10.1021/jm980071x

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Structure-Based Design of Substituted Diphenyl Sulfones and Sulfoxides as Lipophilic Inhibitors of Thymidylate Synthase

Publikováno v: Journal of Medicinal Chemistry. 40:677-683

Six new diphenyl sulfoxide and five new diphenyl sulfones were designed, synthesized, and tested for their inhibition of human and Escherichia coli thymidylate synthase (TS) and of the growth of cells in tissue culture. The best sulfoxide inhibitor o

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e5b00058c01b30433c8d4b3576dc6989
https://doi.org/10.1021/jm960613f

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Synthesis and Biological Evaluation of Novel 2,6-Diaminobenz[cd]indole Inhibitors of Thymidylate Synthase Using the Protein Structure as a Guide

Autor: Varney Michael D, Charlotte A. Bartlett, Stephanie Webber, Catharine A. Morse, Ward W. Smith, Cheryl A. Janson, Cindy L. Palmer, Deal Judith G, Katherine M. Welsh

Publikováno v: Journal of Medicinal Chemistry. 38:1892-1903

The design, synthesis, and biochemical and biological evaluations of a novel series of 2,6-diaminobenz[cd]indole-containing inhibitors of human thymidylate synthase (TS) are described. The compounds are characterized by having either a pyridine or py

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6195c20d8df2ccb34385c8b83e7c523a
https://doi.org/10.1021/jm00011a009

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Biological activity of a novel rationally designed lipophilic thymidylate synthase inhibitor

Autor: Brigid M. O'Connor, Stephanie Webber, John Galivan, Myung S. Rhee, Robert C. Jackson

Publikováno v: Cancer Chemotherapy and Pharmacology. 34:225-229

AG-331 (N6[4-(N-morpholinosulfonyl)benzyl]-N6-methyl-2,6-diamino- benz[cd]indole glucuronate) is a novel lipophilic thymidylate synthase (TS) inhibitor. The properties of this compound were investigated in H35 rat hepatoma cells and in three variant

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a8084c4b82f70594708f2938368e92b5
https://doi.org/10.1007/bf00685081

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