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Autor:
Derrik M Germain, Amy E Siebert, Stephanie Verbeek, Guojing Zhu, Kärt Tomberg, Audrey Cleuren, David Siemieniak, Randal J Westrick
Publikováno v:
Arteriosclerosis, Thrombosis, and Vascular Biology. 35
Factor V Leiden (FVL) is the most common genetic risk factor for venous thromboembolism (VTE). FVL is incompletely penetrant as only 10% of FVL heterozygotes develop VTE. Previously, nearly uniform perinatal lethality was observed in C57BL/6J (B6) mi