Zobrazeno 1 - 9
of 9
pro vyhledávání: '"Stephanie V Rebensburg"'
HIV-1 integrase tetramers are the antiviral target of pyridine-based allosteric integrase inhibitors
Autor:
Pratibha C Koneru, Ashwanth C Francis, Nanjie Deng, Stephanie V Rebensburg, Ashley C Hoyte, Jared Lindenberger, Daniel Adu-Ampratwum, Ross C Larue, Michael F Wempe, Alan N Engelman, Dmitry Lyumkis, James R Fuchs, Ronald M Levy, Gregory B Melikyan, Mamuka Kvaratskhelia
Publikováno v:
eLife, Vol 8 (2019)
Allosteric HIV-1 integrase (IN) inhibitors (ALLINIs) are a promising new class of antiretroviral agents that disrupt proper viral maturation by inducing hyper-multimerization of IN. Here we show that lead pyridine-based ALLINI KF116 exhibits striking
Externí odkaz:
https://doaj.org/article/f3f96045b25c4b55a0b26306772c43fd
Autor:
Melissa Kane, Stephanie V Rebensburg, Matthew A Takata, Trinity M Zang, Masahiro Yamashita, Mamuka Kvaratskhelia, Paul D Bieniasz
Publikováno v:
eLife, Vol 7 (2018)
HIV-1 accesses the nuclear DNA of interphase cells via a poorly defined process involving functional interactions between the capsid protein (CA) and nucleoporins (Nups). Here, we show that HIV-1 CA can bind multiple Nups, and that both natural and m
Externí odkaz:
https://doaj.org/article/849870abdda34cc4ae8942e046a311fe
Autor:
Eric M. Poeschla, Guochao Wei, Ashwanth C. Francis, Szu-Wei Huang, Arun S. Annamalai, Jared Lindenberger, Ross C. Larue, Gregory B. Melikyan, Nikoloz Shkriabai, Mamuka Kvaratskhelia, Vineet N. KewalRamani, James H. Morrison, Stephanie V Rebensburg
Publikováno v:
Nature microbiology
Early events of the human immunodeficiency virus 1 (HIV-1) lifecycle, such as post-entry virus trafficking, uncoating and nuclear import, are poorly characterized because of limited understanding of virus-host interactions. Here, we used mass spectro
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a3fa58166134a2b4d8e84aba7fa0ff6f
https://doi.org/10.1038/s41564-021-00868-1
https://doi.org/10.1038/s41564-021-00868-1
Autor:
Stephanie V Rebensburg, Ronald M. Levy, Gregory B. Melikyan, Daniel Adu-Ampratwum, Ashley C. Hoyte, Alan Engelman, Mamuka Kvaratskhelia, Ross C. Larue, Michael F. Wempe, Dmitry Lyumkis, Nanjie Deng, Ashwanth C. Francis, Jared J. Lindenberger, Pratibha C. Koneru, James R. Fuchs
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5d2b6510316da7cdb54d6b6dceaf2407
https://doi.org/10.7554/elife.46344.sa2
https://doi.org/10.7554/elife.46344.sa2
HIV-1 integrase tetramers are the antiviral target of pyridine-based allosteric integrase inhibitors
Autor:
Nanjie Deng, Daniel Adu-Ampratwum, Mamuka Kvaratskhelia, Jared J. Lindenberger, Pratibha C. Koneru, Ross C. Larue, Gregory B. Melikyan, Alan Engelman, James R. Fuchs, Dmitry Lyumkis, Ashley C. Hoyte, Ashwanth C. Francis, Ronald M. Levy, Stephanie V Rebensburg, Michael F. Wempe
Publikováno v:
eLife
eLife, Vol 8 (2019)
eLife, Vol 8 (2019)
Allosteric HIV-1 integrase (IN) inhibitors (ALLINIs) are a promising new class of antiretroviral agents that disrupt proper viral maturation by inducing hyper-multimerization of IN. Here we show that lead pyridine-based ALLINI KF116 exhibits striking
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0307439108d9fb9ce6c5afb1d0538971
http://europepmc.org/articles/PMC6581505
http://europepmc.org/articles/PMC6581505
Autor:
Tyler A. Wilson, Pratibha C. Koneru, Stephanie V. Rebensburg, Jared J. Lindenberger, Matthew J. Kobe, Nicholas T. Cockroft, Daniel Adu-Ampratwum, Ross C. Larue, Mamuka Kvaratskhelia, James R. Fuchs
Publikováno v:
ACS medicinal chemistry letters. 10(2)
[Image: see text] Allosteric HIV-1 integrase inhibitors (ALLINIs) are a new class of potential antiretroviral therapies with a unique mechanism of action and drug resistance profile. To further extend this class of inhibitors via a scaffold hopping a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::42d33112b13b6f91a7b538d61ada4917
https://pubmed.ncbi.nlm.nih.gov/30783506
https://pubmed.ncbi.nlm.nih.gov/30783506
Autor:
Min Li, Dmitry Lyumkis, Renbin Yang, Rodolfo Ghirlando, Nikoloz Shkriabai, Mamuka Kvaratskhelia, Stephanie V Rebensburg, Robert Craigie, Youngmin Jeon, Dario O. Passos
High-resolution insights into the intasome An essential step in the life cycle of lentiviruses such as HIV-1 is when viral DNA integrates into the host genome, establishing a permanent infection of the host cell. The viral integrase enzyme catalyzes
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::853d858bfb0e2e2fb3d503e9be27f3b6
https://europepmc.org/articles/PMC5508583/
https://europepmc.org/articles/PMC5508583/
Autor:
Nordine Bakouche, Alison Slaughter, Dana Townsend, James R. Fuchs, Jacques J. Kessl, Nikoloz Shkriabai, Mamuka Kvaratskhelia, Ross C. Larue, Paul D. Bieniasz, Sebla B. Kutluay, Stephanie V Rebensburg
Publikováno v:
Cell. 166:1257-1268.e12
While an essential role of HIV-1 integrase (IN) for integration of viral cDNA into human chromosome is established, studies with IN mutants and allosteric IN inhibitors (ALLINIs) have suggested that IN can also influence viral particle maturation. Ho
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::b29dca1e84713529fd43b6196d18bc93
https://doi.org/10.1016/j.cell.2016.07.044
https://doi.org/10.1016/j.cell.2016.07.044