Zobrazeno 1 - 10
of 23
pro vyhledávání: '"Stephanie Szobota"'
Autor:
Stephanie Szobota, Pranav D Mathur, Sairey Siegel, KristenAnn Black, H Uri Saragovi, Alan C Foster
Publikováno v:
PLoS ONE, Vol 14, Iss 10, p e0224022 (2019)
Neurotrophins and their mimetics are potential treatments for hearing disorders because of their trophic effects on spiral ganglion neurons (SGNs) whose connections to hair cells may be compromised in many forms of hearing loss. Studies in noise or o
Externí odkaz:
https://doaj.org/article/0e9581df75904907b9947384eccca688
Autor:
Shai Berlin, Stephanie Szobota, Andreas Reiner, Elizabeth C Carroll, Michael A Kienzler, Alice Guyon, Tong Xiao, Dirk Trauner, Ehud Y Isacoff
Publikováno v:
eLife, Vol 5 (2016)
NMDA receptors, which regulate synaptic strength and are implicated in learning and memory, consist of several subtypes with distinct subunit compositions and functional properties. To enable spatiotemporally defined, rapid and reproducible manipulat
Externí odkaz:
https://doaj.org/article/0646bd9395e1429abc6c428f0d794842
Autor:
Sairey Siegel, Stephanie Szobota, Alan C. Foster, Alba Galan, Marinko V. Sarunic, Fouad Brahimi, H. Uri Saragovi
Publikováno v:
Molecular Pharmacology. 100:491-501
The neurotrophin growth factors bind and activate two types of cell surface receptors: the tropomyosin receptor kinase (Trk) family and p75. TrkA, TrkB, and TrkC are bound preferentially by nerve growth factor, brain-derived neurotrophic factor, and
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dcbfba2523444945ec58acf9448bd81b
https://doi.org/10.1124/molpharm.121.000301
https://doi.org/10.1124/molpharm.121.000301
Autor:
Alan C. Foster, Stephanie Szobota, Fabrice Piu, Bonnie E. Jacques, David R. Moore, Victoria A. Sanchez, Jeffery J. Anderson
Publikováno v:
The Journal of the Acoustical Society of America. 151(6)
Currently, there are no approved medicines available for the treatment of hearing loss. However, research over the past two decades has contributed to a growing understanding of the pathological mechanisms in the cochlea that result in hearing diffic
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::38adb87d1b7bb082f6d7233567e119e5
https://pubmed.ncbi.nlm.nih.gov/35778165
https://pubmed.ncbi.nlm.nih.gov/35778165
Autor:
Pranav D. Mathur, Stephanie Szobota, H. Uri Saragovi, Sairey Siegel, KristenAnn Black, Alan Foster
Publikováno v:
PLoS ONE
PLoS ONE, Vol 14, Iss 10, p e0224022 (2019)
PLoS ONE, Vol 14, Iss 10, p e0224022 (2019)
Neurotrophins and their mimetics are potential treatments for hearing disorders because of their trophic effects on spiral ganglion neurons (SGNs) whose connections to hair cells may be compromised in many forms of hearing loss. Studies in noise or o
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::11010f359bf15e1bf826c8f3a17d62e2
https://doi.org/10.1371/journal.pone.0224022
https://doi.org/10.1371/journal.pone.0224022
Autor:
Tong Xiao, Shai Berlin, Ehud Y. Isacoff, Dirk Trauner, Andreas Reiner, Alice Guyon, Stephanie Szobota, Michael A. Kienzler, Elizabeth C. Carroll
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::b1908e48bfdbb3fbdfc6810debc221b6
https://doi.org/10.7554/elife.12040.024
https://doi.org/10.7554/elife.12040.024
Publikováno v:
Nature neuroscience
Genetically targeted light-activated ion channels and pumps make it possible to determine the role of specific neurons in neuronal circuits, information processing and behavior. Here, we describe the development of a K+-selective ionotropic glutamate
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::405e5d7e49af70cdcd04fcd37224ebb8
https://doi.org/10.1038/nn.2589
https://doi.org/10.1038/nn.2589
Autor:
Ehud Y. Isacoff, Stephanie Szobota
Publikováno v:
Annu Rev Biophys
Advances in optics, genetics, and chemistry have enabled the investigation of brain function at all levels, from intracellular signals to single synapses, whole cells, circuits, and behavior. Until recent years, these research tools have been utilize
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8d84d6bfdbb315f1952c1bfdcc5d04ac
https://doi.org/10.1146/annurev.biophys.093008.131400
https://doi.org/10.1146/annurev.biophys.093008.131400
Autor:
Pau Gorostiza, Albert Y. Lau, Matthew Volgraf, Rika Numano, Dirk Trauner, Benoît Roux, Stephanie Szobota, Ehud Y. Isacoff
Publikováno v:
Proceedings of the National Academy of Sciences. 106:6814-6819
Photoswitched tethered ligands (PTLs) can be used to remotely control protein function with light. We have studied the geometric and conformational factors that determine the efficacy of PTL gating in the ionotropic glutamate receptor iGluR6 using a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f48dbd14dc537078087e432794b9a054
https://doi.org/10.1073/pnas.0811899106
https://doi.org/10.1073/pnas.0811899106
Autor:
Stephanie Szobota, Ehud Y. Isacoff, Dirk Trauner, Cheng Sun, Matthew Volgraf, Yuan Wang, Zhaowei Liu, Sheng Wang, Xiang Zhang
Publikováno v:
Nano Letters. 7:3859-3863
A key technical barrier to furthering our understanding of complex neural networks has been the lack of tools for the simultaneous spatiotemporal control and detection of activity in a large number of neurons. Here, we report an all-optical system fo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8ce1953aca97304e961dae42e38efb9a
https://doi.org/10.1021/nl072783t
https://doi.org/10.1021/nl072783t