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Autor:
David C. Boyles, Stephanie Schuyler, Edward J. Hessler, Jeffrey A. Pfefferkorn, Daniel Merritt Bowles, Chulho Choi
Publikováno v:
Organic Process Research & Development. 15:148-157
Early process development work toward a promising pyrazole-based HMG-CoA reductase inhibitor is described. PF-03052334-02 (1) was prepared in 14 synthetic steps with a 21% overall yield, highlighted by a modified three-step hydroxypyrazole formation