Zobrazeno 1 - 10
of 45
pro vyhledávání: '"Stephanie Rigaud"'
Autor:
Gisele V. Baracho, Nihan Kara, Stephanie Rigaud, Evelyn Lo, Stephanie J. Widmann, Aaron J. Tyznik
Publikováno v:
STAR Protocols, Vol 3, Iss 1, Pp 101069- (2022)
Summary: Cytotoxic T lymphocytes and natural killer (NK) cells are key effector cells in immune defenses against intracellular pathogens and cancer. In human blood, effector T and NK cytotoxic cells comprise a diverse and relatively rare group of cel
Externí odkaz:
https://doaj.org/article/f277248faba14c1fb8f13b03a4e4bfa4
Autor:
Luise Westernberg, Claire Conche, Yina Hsing Huang, Stephanie Rigaud, Yisong Deng, Sabine Siegemund, Sayak Mukherjee, Lyn'Al Nosaka, Jayajit Das, Karsten Sauer
Publikováno v:
eLife, Vol 5 (2016)
β-selection is the most pivotal event determining αβ T cell fate. Here, surface-expression of a pre-T cell receptor (pre-TCR) induces thymocyte metabolic activation, proliferation, survival and differentiation. Besides the pre-TCR, β-selection al
Externí odkaz:
https://doaj.org/article/1ae57ac0454547c3a658659fd48d389b
Autor:
Sayak Mukherjee, Stephanie Rigaud, Sang-Cheol Seok, Guo Fu, Agnieszka Prochenka, Michael Dworkin, Nicholas R. J. Gascoigne, Veronica J. Vieland, Karsten Sauer, Jayajit Das
Publikováno v:
PLoS ONE, Vol 9, Iss 1 (2014)
Externí odkaz:
https://doaj.org/article/d7a51a6eab3c414caf81a1922439bc18
Autor:
Sayak Mukherjee, Stephanie Rigaud, Sang-Cheol Seok, Guo Fu, Agnieszka Prochenka, Michael Dworkin, Nicholas R J Gascoigne, Veronica J Vieland, Karsten Sauer, Jayajit Das
Publikováno v:
PLoS ONE, Vol 8, Iss 9, p e73937 (2013)
The inositol-phosphate messenger inositol(1,3,4,5)tetrakisphosphate (IP4) is essential for thymocyte positive selection by regulating plasma-membrane association of the protein tyrosine kinase Itk downstream of the T cell receptor (TCR). IP4 can act
Externí odkaz:
https://doaj.org/article/6d4f84af532a4166a083be6fd3b99e30
Autor:
Nupura Hirve, Roman M Levytskyy, Stephanie Rigaud, David M Guimond, Tomasz Zal, Karsten Sauer, Constantine D Tsoukas
Publikováno v:
PLoS ONE, Vol 7, Iss 9, p e45158 (2012)
Binding of the membrane phospholipid phosphatidylinositol 3,4,5-trisphosphate (PIP(3)) to the Pleckstrin Homology (PH) domain of the Tec family protein tyrosine kinase, Inducible T cell Kinase (ITK), is critical for the recruitment of the kinase to t
Externí odkaz:
https://doaj.org/article/97cbf54ebbe84f86a9ad66d1ea411332
Publikováno v:
The Journal of Immunology. 206:27.14-27.14
Cytotoxic T lymphocytes (CTLs) and natural killer (NK) cells have become attractive therapeutic targets for cancer immunotherapy because of their efficient mechanisms for killing cancerous cells. Both effector CTLs and mature NK cells are endowed wit
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::5875b5641f6c7f61f1fe918d7c12cf30
https://doi.org/10.4049/jimmunol.206.supp.27.14
https://doi.org/10.4049/jimmunol.206.supp.27.14
Autor:
Douglas R. Green, Christian J. Maine, Linda A. Sherman, Yang D. Dai, Xiaotian Lin, Stephanie Rigaud, Stephane Pelletier, Greg S. Martin, Liping Yu, Kristi Marquardt, Ling Jiang, Sebastien Gingras, Karsten Sauer, Sergey Kupriyanov, Alberto R. Rodriguez
Publikováno v:
Diabetes
An allelic variant of protein tyrosine phosphatase nonreceptor type 22 (PTPN22), PTPN22R620W, is strongly associated with type 1 diabetes (T1D) in humans and increases the risk of T1D by two- to fourfold. The NOD mouse is a spontaneous T1D model that
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3102cae6b42bdfe60ab1c255633109b2
https://doi.org/10.2337/db16-0061
https://doi.org/10.2337/db16-0061
Autor:
Karsten Sauer, Lana Schaffer, Luise Westernberg, Stephanie Rigaud, Sabine Siegemund, Blake Broaten, Claire Conche, Steven R. Head
Publikováno v:
Blood. 125:2786-2797
Tight regulation of hematopoietic stem cell (HSC) homeostasis ensures lifelong hematopoiesis and prevents blood cancers. The mechanisms balancing HSC quiescence with expansion and differentiation into hematopoietic progenitors are incompletely unders
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ede8696cf945ad77c48dcab5c0d88327
https://doi.org/10.1182/blood-2014-06-583187
https://doi.org/10.1182/blood-2014-06-583187
Autor:
Vasily Rybakin, Wolfgang Paster, Karsten Sauer, Oreste Acuto, Florence Lambolez, Hilde Cheroutre, Joanna Brzostek, Javier Casas, John A. H. Hoerter, Nicholas R. J. Gascoigne, Stephanie Rigaud, Guo Fu
Publikováno v:
Nature
Development of a self-tolerant T-cell receptor (TCR) repertoire with the potential to recognize the universe of infectious agents depends on proper regulation of TCR signalling. The repertoire is whittled down during T-cell development in the thymus
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::089d2cfdd46796e94d6d2bf425dce7f0
http://europepmc.org/articles/PMC3977001
http://europepmc.org/articles/PMC3977001
Autor:
Luise Sternberg, Yina H. Huang, A. Helena Jonsson, Karsten Sauer, Anthony R. French, Joseph A. Wahle, Wayne M. Yokoyama, Stephanie Rigaud, Sabine Siegemund, Eugene Park
Publikováno v:
Blood. 121:286-297
Natural killer (NK) cells have important functions in cancer immunosurveillance, BM allograft rejection, fighting infections, tissue homeostasis, and reproduction. NK cell–based therapies are promising treatments for blood cancers. Overcoming their
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6c57a8746aff4beb32a0dafe33b66f4f
https://doi.org/10.1182/blood-2012-05-429241
https://doi.org/10.1182/blood-2012-05-429241