Zobrazeno 1 - 10
of 68
pro vyhledávání: '"Stephanie Planque"'
Publikováno v:
The FASEB Journal. 33
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::f5cee8edd064df6e8a3a3e91aaac5b28
https://doi.org/10.1096/fasebj.2019.33.1_supplement.634.10
https://doi.org/10.1096/fasebj.2019.33.1_supplement.634.10
Publikováno v:
Mech Ageing Dev
Quantum mechanics-based design of useful catalytic antibodies (catabodies) failed because of the uncertain structure of the dynamic catalyst-substrate complex. The Catabody Platform emerged from discovery of beneficial germline gene catabodies that h
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8900600c9b04a2a001c2781c97c3bda3
https://doi.org/10.1016/j.mad.2019.111188
https://doi.org/10.1016/j.mad.2019.111188
Autor:
Stephanie Planque, Jinghong Kou, Sudhir Paul, Ken-ichiro Fukuchi, Junling Yang, Min Song, Robert Lalonde
The amyloid hypothesis has been the main theory to explain the etiology of Alzheimer’s disease (AD) and provided potentially preventive and therapeutic targets. Although Aβ-immunotherapy holds promise for AD, its vascular complications reduce the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::439a4dd6ac1539e381f5e3c360720beb
https://doi.org/10.1016/b978-0-12-809813-4.00006-5
https://doi.org/10.1016/b978-0-12-809813-4.00006-5
Publikováno v:
Natural Antibodies ISBN: 9781493971794
Catalytic antibodies (catabodies) hold potential for superior immunotherapy because of their turnover capability and no or minimal induction of inflammatory responses. Catabodies neutralize and remove target antigens more potently than conventional a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::c2e7d62e00c825d1f056fbe38a5bdec0
https://doi.org/10.1007/978-1-4939-7180-0_9
https://doi.org/10.1007/978-1-4939-7180-0_9
Publikováno v:
Natural Antibodies ISBN: 9781493971794
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::5630a83c3c45863b44f95f2fb0356c8b
https://doi.org/10.1007/978-1-4939-7180-0_16
https://doi.org/10.1007/978-1-4939-7180-0_16
Autor:
Yasuhiro Nishiyama, Brian O'Nuallain, Eric L. Brown, Sari Sonoda, Kenji Watanabe, Sudhir Paul, Sarah K. Murphy, Stanley R. Primmer, Stephanie Planque, Mariko Hara, Richard Massey, Yukie Mitsuda
Publikováno v:
Journal of Biological Chemistry. 289:13243-13258
Peptide bond-hydrolyzing catalytic antibodies (catabodies) could degrade toxic proteins, but acquired immunity principles have not provided evidence for beneficial catabodies. Transthyretin (TTR) forms misfolded β-sheet aggregates responsible for ag
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c88c167d9e9ca4173044fb117362644f
https://doi.org/10.1074/jbc.m114.557231
https://doi.org/10.1074/jbc.m114.557231
Autor:
Min Song, Abhinandan Pattanayak, Jinghong Kou, Jeong Eun Lim, Ken Ichiro Fukuchi, Sudhir Paul, Stephanie Planque, Junling Yang
Publikováno v:
Molecular Neurobiology. 51:43-56
Accumulation of amyloid beta-peptide (Aβ) in the brain is hypothesized to be a causal event leading to dementia in Alzheimer's disease (AD). Aβ vaccination removes Aβ deposits from the brain. Aβ immunotherapy, however, may cause T cell- and/or Fc
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::359bbfaf5221ea4920a197773de657ac
https://doi.org/10.1007/s12035-014-8691-z
https://doi.org/10.1007/s12035-014-8691-z
Publikováno v:
Expert Review of Vaccines. 9:1027-1043
Traditional HIV vaccine approaches have proved ineffective because the immunodominant viral epitopes are mutable and the conserved epitopes necessary for infection are not sufficiently immunogenic. The CD4 binding site expressed by the HIV envelope p
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a73e5baf220dcb4263dc0c105750d4cb
https://doi.org/10.1586/erv.10.77
https://doi.org/10.1586/erv.10.77
Publikováno v:
Journal of Clinical Immunology. 30:43-49
Objectives The objectives of this study are to (1) evaluate the ability of the immune system to synthesize specific antibodies that catalyze the degradation of amyloid beta peptide (Abeta) and to (2) evaluate the prospect of developing a catalytic IV
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ecd2042aea1cbded4796391752af0c4b
https://doi.org/10.1007/s10875-010-9414-5
https://doi.org/10.1007/s10875-010-9414-5