Severe Ankyrin-R deficiency results in impaired surface retention and lysosomal degradation of RhAG in human erythroblasts

Autor: Timothy J. Satchwell, Amanda J. Bell, Bethan R. Hawley, Stephanie Pellegrin, Kathryn E. Mordue, Cees Th. B. M. van Deursen, Nicole Heitink-ter Braak, Gerwin Huls, Mathie P.G Leers, Eline Overwater, Rienk Y. J. Tamminga, Bert van der Zwaag, Elisa Fermo, Paola Bianchi, Richard van Wijk, Ashley M. Toye

Publikováno v: Haematologica, Vol 101, Iss 9 (2016)

Ankyrin-R provides a key link between band 3 and the spectrin cytoskeleton that helps to maintain the highly specialized erythrocyte biconcave shape. Ankyrin deficiency results in fragile spherocytic erythrocytes with reduced band 3 and protein 4.2 e

Externí odkaz: https://doaj.org/article/fd21b983b35844cfb39c72239f261d93

The majority of the in vitro erythroid expansion potential resides in CD34− cells, outweighing the contribution of CD34+ cells and significantly increasing the erythroblast yield from peripheral blood samples

Autor: Emile van den Akker, Timothy J. Satchwell, Stephanie Pellegrin, Geoff Daniels, Ashley M. Toye

Publikováno v: Haematologica, Vol 95, Iss 9 (2010)

The study of human erythropoiesis in health and disease requires a robust culture system that consistently and reliably generates large numbers of immature erythroblasts that can be induced to differentiate synchronously. We describe a culture method

Externí odkaz: https://doaj.org/article/fa0661345cc74a648abd23d45c72e8cb

BNIP3L/NIX regulates both mitophagy and pexophagy

Autor: Léa P Wilhelm, Juan Zapata‐Muñoz, Beatriz Villarejo‐Zori, Stephanie Pellegrin, Catarina Martins Freire, Ashley M Toye, Patricia Boya, Ian G Ganley

Publikováno v: Digital.CSIC. Repositorio Institucional del CSIC
instname
Wilhelm, L P, Zapata-Muñoz, J, Villarejo-Zori, B, Pellegrin, S, Freire, C M, Toye, A M, Boya, P & Ganley, I G 2022, ' BNIP3L/NIX regulates both mitophagy and pexophagy ', EMBO Journal, vol. 41, no. 24, e111115 . https://doi.org/10.15252/embj.2022111115

19 p.-6 fig.
Mitochondria and peroxisomes are closely related metabolic organelles, both in terms of origin and in terms of function. Mitochondria and peroxisomes can also be turned over by autophagy, in processes termed mitophagy and pexophagy,

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4eba8cfeadbb0c827b1bf4375338ff8c
http://hdl.handle.net/10261/281336

The small GTPase Rif is an alternative trigger for the formation of actin stress fibers in epithelial cells

Autor: Stephanie Pellegrin, Harry Mellor, Lifei Fan, Alice N. Scott

Publikováno v: Journal of Cell Science. 123:1247-1252

Actin stress fibers are fundamental components of the actin cytoskeleton that produce contractile force in non-muscle cells. The formation of stress fibers is controlled by the small GTPase RhoA and two highly related proteins, RhoB and RhoC. Togethe

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::153e9c09ee1a3cdf7057dbf3a566b7d9
https://doi.org/10.1242/jcs.061754

The Rif GTPase regulates cytoskeletal signaling from plexinA4 to promote neurite retraction

Autor: Lifei Fan, Stephanie Pellegrin, Harry Mellor, Huijuan Yan, Morigen

Publikováno v: Neuroscience letters. 590

The small GTPase Rif is required for the early stages of dendritic spine formation in neurons, acting through the formin mDia2 to control actin polymerization. Rif is expressed at high levels in the brain, suggesting broader roles in neuronal functio

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4b8a1a8b4b2c9f32d4c4e1fff4a9eeff
https://pubmed.ncbi.nlm.nih.gov/25668492