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pro vyhledávání: '"Stephanie Patchett"'
A molecular sensor determines the ubiquitin substrate specificity of SARS-CoV-2 papain-like protease
Autor:
Stephanie Patchett, Zongyang Lv, Wioletta Rut, Miklos Békés, Marcin Drag, Shaun K. Olsen, Tony T. Huang
Publikováno v:
Cell Reports, Vol 36, Iss 13, Pp 109754- (2021)
Summary: The SARS-CoV-2 papain-like protease (PLpro) is a target for antiviral drug development. It is essential for processing viral polyproteins for replication and functions in host immune evasion by cleaving ubiquitin (Ub) and ubiquitin-like prot
Externí odkaz:
https://doaj.org/article/06ae877aa85148879905aa3b2b01ed9c
Autor:
Isabel J.F. Hofman, Stephanie Patchett, Mark van Duin, Ellen Geerdens, Jelle Verbeeck, Lucienne Michaux, Michel Delforge, Pieter Sonneveld, Arlen W. Johnson, Kim De Keersmaecker
Publikováno v:
Haematologica, Vol 102, Iss 8 (2017)
Externí odkaz:
https://doaj.org/article/bd894a694cfb40e0bb633e90661d2f03
Publikováno v:
PLoS Genetics, Vol 13, Iss 7, p e1006894 (2017)
Mutations in the ribosomal protein Rpl10 (uL16) can be drivers of T-cell acute lymphoblastic leukemia (T-ALL). We previously showed that these T-ALL mutations disrupt late cytoplasmic maturation of the 60S ribosomal subunit, blocking the release of t
Externí odkaz:
https://doaj.org/article/c3038b57082e491d90a79463a9d1b5cf
Publikováno v:
PLoS Genetics, Vol 11, Iss 12, p e1005732 (2015)
Ribosome profiling produces snapshots of the locations of actively translating ribosomes on messenger RNAs. These snapshots can be used to make inferences about translation dynamics. Recent ribosome profiling studies in yeast, however, have reached c
Externí odkaz:
https://doaj.org/article/0158a937d6394ba1941a978c797897fc
Autor:
Stephanie Patchett, Zongyang Lv, Marcin Drag, Digant Nayak, Shaun K. Olsen, Scott J. Snipas, Farid El Oualid, Wioletta Rut, Tony T. Huang, Mikolaj Zmudzinski, Miklós Békés
In December 2019, the first cases of a novel coronavirus infection causing COVID-19 were diagnosed in Wuhan, China. Viral Papain-Like cysteine protease (PLpro, NSP3) is essential for SARS-CoV-2 replication and represents a promising target for the de
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::1a508431e546e9ec7f5cfd6420e4003e
https://doi.org/10.1101/2020.04.29.068890
https://doi.org/10.1101/2020.04.29.068890
A molecular sensor determines the ubiquitin substrate specificity of SARS-CoV-2 papain-like protease
Autor:
Zongyang Lv, Tony T. Huang, Marcin Drag, Shaun K. Olsen, Miklós Békés, Stephanie Patchett, Wioletta Rut
Publikováno v:
Cell Reports, Vol 36, Iss 13, Pp 109754-(2021)
Cell Reports
Cell Reports
The SARS-CoV-2 papain-like protease (PLpro) is a target for antiviral drug development. It is essential for processing viral polyproteins for replication and functions in host immune evasion by cleaving ubiquitin (Ub) and ubiquitin-like protein (Ubl)
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4bc4e41bf3ab64e1e886cfedc49ce761
https://doi.org/10.1016/j.celrep.2021.109754
https://doi.org/10.1016/j.celrep.2021.109754
Autor:
Arlen W. Johnson, Kim De Keersmaecker, Michel Delforge, Stephanie Patchett, Mark van Duin, Jelle Verbeeck, Pieter Sonneveld, Lucienne Michaux, Ellen Geerdens, Isabel J.F. Hofman
Publikováno v:
Haematologica, 102(8), E317-E320. Ferrata Storti Foundation
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::781738832047b2ab54127d63d11d8b2f
https://doi.org/10.3324/haematol.2016.162198
https://doi.org/10.3324/haematol.2016.162198
Publikováno v:
PLoS Genetics, Vol 13, Iss 7, p e1006894 (2017)
PLoS Genetics
PLoS Genetics
Mutations in the ribosomal protein Rpl10 (uL16) can be drivers of T-cell acute lymphoblastic leukemia (T-ALL). We previously showed that these T-ALL mutations disrupt late cytoplasmic maturation of the 60S ribosomal subunit, blocking the release of t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::01996cb4a22d8de2809362944521ffe0
http://europepmc.org/articles/PMC5536393?pdf=render
http://europepmc.org/articles/PMC5536393?pdf=render
Autor:
Joachim Frank, Stephanie Patchett, Andrey G. Malyutin, Sharmishtha Musalgaonkar, Arlen W. Johnson
During ribosome biogenesis in eukaryotes, nascent subunits are exported to the cytoplasm in a functionally inactive state. 60S subunits are activated through a series of cytoplasmic maturation events. The last known events in the cytoplasm are the re
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e51c0695193d129d686e99dda5c0aa74
https://europepmc.org/articles/PMC5376978/
https://europepmc.org/articles/PMC5376978/
Autor:
Jonathan D. Dinman, Vivek M. Advani, Arlen W. Johnson, Sergey O. Sulima, Kim De Keersmaecker, Stephanie Patchett
Publikováno v:
Proceedings of the National Academy of Sciences. 111:5640-5645
Ribosomopathies are a class of diseases caused by mutations that affect the biosynthesis and/or functionality of the ribosome. Although they initially present as hypoproliferative disorders, such as anemia, patients have elevated risk of hyperprolife
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dd77a9931b48aee5ecfef0ab2d1d043e
https://doi.org/10.1073/pnas.1400247111
https://doi.org/10.1073/pnas.1400247111