Zobrazeno 1 - 10
of 12
pro vyhledávání: '"Stephanie Pack"'
Autor:
Junghyo Jo, Oksana Gavrilova, Stephanie Pack, William Jou, Shawn Mullen, Anne E Sumner, Samuel W Cushman, Vipul Periwal
Publikováno v:
PLoS Computational Biology, Vol 5, Iss 3, p e1000324 (2009)
Adipose tissue grows by two mechanisms: hyperplasia (cell number increase) and hypertrophy (cell size increase). Genetics and diet affect the relative contributions of these two mechanisms to the growth of adipose tissue in obesity. In this study, th
Externí odkaz:
https://doaj.org/article/89669567ec3b4f58a2e96f2f4bf1fc87
Autor:
Tao Wang, Yingying Tang, Stephanie Pack, Mechthild Prinz, Krunal R. Shah, Barbara A. Sampson, Dawei Wang, Sung Yon Um
Publikováno v:
Circulation. 123:2219-2225
Background— In-hospital pulmonary embolism (PE) has been extensively studied in large populations; however, out-of-hospital fatal PE studies are rare. Here, we systematically evaluated a large number of decedents who suffered fatal PE outside of ho
Autor:
William Jou, Dinesh Gautam, Jürgen Wess, Jian H. Li, Yinghong Cui, Stephanie Pack, Jongrye Jeon, Oksana Gavrilova
Publikováno v:
Cell Metabolism. 4:363-375
SummaryMost animal models of obesity and hyperinsulinemia are associated with increased vagal cholinergic activity. The M3 muscarinic acetylcholine receptor subtype is widely expressed in the brain and peripheral tissues and plays a key role in media
Autor:
Lee S. Weinstein, Marga Frontera, Oksana Gavrilova, Stephanie Pack, Gavin Kelsey, Antonius Plagge, Edwin W. Lai, William Jou, Tao Xie
Publikováno v:
Journal of Biological Chemistry. 281:18989-18999
The complex imprinted Gnas locus encodes several gene products including G(s)alpha, the ubiquitously expressed G protein alpha-subunit required for receptor-stimulated cAMP generation, and the neuroendocrine-specific G(s)alpha isoform XLalphas. XLalp
Autor:
Oksana Gavrilova, Min Chen, Lisa M. Nackers, Annie Nguyen, Lee S. Weinstein, Javier Lorenzo, Stephanie Pack, Laura Shen, Wei-Qin Zhao, William Jou
Publikováno v:
Journal of Clinical Investigation. 115:3217-3227
The G protein G(s)alpha is essential for hormone-stimulated cAMP generation and is an important metabolic regulator. We investigated the role of liver G(s)-signaling pathways by developing mice with liver-specific G(s)alpha deficiency (LGsKO mice). L
Autor:
Shoshana Yakar, Stephanie Pack, William Jou, Oksana Gavrilova, Zeenat Asghar, Yuka Toyoshima, Derek LeRoith, Michael B. Wheeler
Publikováno v:
Endocrinology. 146:4024-4035
Leptin has metabolic effects on peripheral tissues including muscle, liver, and pancreas, and it has been successfully used to treat lipodystrophic diabetes, a leptin-deficient state. To study whether leptin therapy can be used for treatment of more
Autor:
Alexandra H. Minn, David M. Harlan, Anath Shalev, Stephanie Pack, Charles Vinson, Oksana Gavrilova, Steven C. Hoffmann, Noelle B Patterson
Publikováno v:
Biochemical and Biophysical Research Communications. 310:641-645
Resistin, a recently described adipocyte factor, is regulated by peroxisome proliferator-activated receptor gamma (PPARγ) agonists. While resistin has been proposed to mediate insulin resistance in rodents, little is known about human resistin and i
Autor:
Charles Vinson, Lionel Feigenbaum, William Jou, Raghunath Chatterjee, Stephanie Pack, Michael Eckhaus, Oksana Gavrilova, Paramita Bhattacharya, Max Myakishev, Kimberly Glass, Jaideep Moitra
Publikováno v:
Journal of molecular endocrinology. 46(3)
Adipose-specific inactivation of both AP-1 and CCAAT-enhancer-binding protein (C/EBP) families of B-ZIP transcription factors in transgenic mice causes severe lipoatrophy. To evaluate whether inactivation of only C/EBP members was critical for lipoat
Autor:
John A. Chiorini, Nancy K. Dwyer, Stephanie Pack, David M. Harlan, William Jou, Roland A Owens, Michael Schmidt, Victor J McAlister, Oksana Gavrilova, Eric Liu, Klaus Pechhold, E. Joan Blanchette-Mackie, Anthony T Craig
Publikováno v:
Virology Journal, Vol 6, Iss 1, p 61 (2009)
Virology Journal
Virology Journal
Background Pancreatic islet transplantation is a promising treatment for type I diabetes mellitus, but current immunosuppressive strategies do not consistently provide long-term survival of transplanted islets. We are therefore investigating the use
Autor:
Derek LeRoith, Patricia Pennisi, William Jou, Stephanie Pack, Jennifer Setser-Portas, Yan Tang, Joyce East-Palmer, Hyunsook Kim, Vincent C. Manganiello, Oksana Gavrilova
Publikováno v:
American journal of physiology. Endocrinology and metabolism. 290(6)
The antiobesity and antidiabetic effects of the β3-adrenergic agonists were investigated on nonobese type 2 diabetic MKR mice after injection with a β3-adrenergic agonist, CL-316243. An intact response to acute CL-316243 treatment was observed in M