Zobrazeno 1 - 10
of 18
pro vyhledávání: '"Stephanie Norton"'
Autor:
Stephanie Norton, Uma Chandrachud, Anton Petcherski, Sasja Heetveld, Stephen J. Haggarty, Pavlina Wolf, Hye Jin Oh, Susan L. Cotman, Madeleine C Klein, Alexandra M. Simas, Wen-Ning Zhao, Mathew W. Walker, Emyr Lloyd-Evans
Publikováno v:
Journal of Biological Chemistry. 290:14361-14380
Abnormal accumulation of undigested macromolecules, often disease-specific, is a major feature of lysosomal and neurodegenerative disease and is frequently attributed to defective autophagy. The mechanistic underpinnings of the autophagy defects are
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ace6ca77dfebd7e3e4eacc54e024612c
https://doi.org/10.1074/jbc.m114.621706
https://doi.org/10.1074/jbc.m114.621706
Autor:
Alex Kentsis, A. Thomas Look, James E. Bradner, Frederic Baleydier, Ruta Grebliunaite, Jon C. Aster, Huipin Yuan, Andrew P. Weng, Françoise Pflumio, Li Pan, Lynn VerPlank, Jason J. Marineau, Stephanie Norton, Richard W.J. Groen, Frank An, Jason Burbank, Benjamin Uzan, Constantine S. Mitsiades, Hanno Steen, Sandrine Poglio, Nicola Tolliday, Casie Reed, Elena Kozakewich, Paul A. Clemons, Alejandro Gutierrez
Publikováno v:
Journal of Clinical Investigation, 124(2), 644-55. The American Society for Clinical Investigation
Gutierrez, A, Pan, L, Groen, R W J, Baleydier, F, Kentsis, A, Marineau, J, Grebliunaite, R, Kozakewich, E, Reed, C, Pflumio, F, Poglio, S, Uzan, B, Clemons, P, VerPlank, L, An, F, Burbank, J, Norton, S, Tolliday, N, Steen, H, Weng, A P, Yuan, H, Bradner, J E, Mitsiades, C, Look, A T & Aster, J C 2014, ' Phenothiazines induce PP2A-mediated apoptosis in T cell acute lymphoblastic leukemia ', Journal of Clinical Investigation, vol. 124, no. 2, pp. 644-55 . https://doi.org/10.1172/JCI65093
Gutierrez, A, Pan, L, Groen, R W J, Baleydier, F, Kentsis, A, Marineau, J, Grebliunaite, R, Kozakewich, E, Reed, C, Pflumio, F, Poglio, S, Uzan, B, Clemons, P, VerPlank, L, An, F, Burbank, J, Norton, S, Tolliday, N, Steen, H, Weng, A P, Yuan, H, Bradner, J E, Mitsiades, C, Look, A T & Aster, J C 2014, ' Phenothiazines induce PP2A-mediated apoptosis in T cell acute lymphoblastic leukemia ', Journal of Clinical Investigation, vol. 124, no. 2, pp. 644-55 . https://doi.org/10.1172/JCI65093
T cell acute lymphoblastic leukemia (T-ALL) is an aggressive cancer that is frequently associated with activating mutations in NOTCH1 and dysregulation of MYC. Here, we performed 2 complementary screens to identify FDA-approved drugs and drug-like sm
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::42754d1bf080836a1fcd220ac6453f2e
https://doi.org/10.1172/jci65093
https://doi.org/10.1172/jci65093
Autor:
Melissa Malvaez, Stephen J. Haggarty, Emily L. Ricq, Stephanie Norton, Marcelo A. Wood, Ramesh Neelamegam, Ian T. Hill, Debasis Patnaik, Jacob M. Hooker, Stephen M. Carlin
Publikováno v:
ACS Chemical Neuroscience. 3:120-128
Modulation of histone modifications in the brain may represent a new mechanism for brain disorder therapy. Post-translational modifications of histones regulate gene expression, affecting major cellular processes such as proliferation, differentiatio
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c4e812aaa2839258e9739a05317fb1bd
https://doi.org/10.1021/cn200104y
https://doi.org/10.1021/cn200104y
Autor:
Wen-Ning Zhao, Peter S. Klein, Timothy A. Lewis, Krista M. Hennig, Rebecca L. Maglathlin, Surya A. Reis, Ralph Mazitschek, Stephen J. Haggarty, Balaram Ghosh, Stephanie Norton, Daniel M. Fass, Rishita Shah
Publikováno v:
ACS Medicinal Chemistry Letters. 2:39-42
Carboxylic acids with known central nervous system and histone deacetylase (HDAC) inhibitory activities were converted to hydroxamic acids and tested using a suite of in vitro biochemical assays with recombinant HDAC isoforms, cell based assays in hu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a9675246d390447ae784c860f1881365
https://doi.org/10.1021/ml1001954
https://doi.org/10.1021/ml1001954
Autor:
George W. Uetz, Stephanie Norton
Publikováno v:
Behavioral Ecology and Sociobiology. 61:631-641
Individual variation in female preference for male traits may influence mate choice, especially if benefits and costs of choosiness vary with the range of available males or reproductive timing. We examined variation in female preference for male leg
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::b117dffc70ba3aa3fdf329f2844020d0
https://doi.org/10.1007/s00265-006-0293-y
https://doi.org/10.1007/s00265-006-0293-y
Autor:
Dawn Karima Pettigrew, J. Anthony Paredes, Steven Ross Evans, Andrew Gulliford, Peter d'Errico, Robert E. Ackerman, Lindsey Claire Smith, James S. Frideres, Stephanie Norton Joynes, Malinda Maynor Lowery, Victoria Smith, Charles Cambridge, James D. Drake, Michelle L. LaPena, William C. Meadows, Richard Fehr, Selene Phillips, Delilah Orr, Naomi McIlwraith, David Mart�nez
Publikováno v:
American Indian Culture and Research Journal. 30:131-181
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::522559158a9d7b31012b0a58fd808c6b
https://doi.org/10.17953/aicr.30.1.x3311p6335374135
https://doi.org/10.17953/aicr.30.1.x3311p6335374135
Autor:
Stephanie Norton, George W. Uetz
Publikováno v:
Journal of Arachnology. 33:16-24
Courtship behavior has been studied extensively in the wolf spider Schizocosa ocreata (Hentz) (Araneae, Lycosidae). While much research has tested predictions of sexual selection theory regarding male traits and female mate choice, some critical assu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::d0e663ab28e5a71283063726328f428b
https://doi.org/10.1636/s02-72
https://doi.org/10.1636/s02-72
Autor:
Cody L. Gilleland, Stephanie Norton, Mehmet Fatih Yanik, Chrysanthi Samara, Christopher Rohde, Stephen J. Haggarty
Publikováno v:
Proceedings of the National Academy of Sciences of the United States of America. 107(43)
Discovery of molecular mechanisms and chemical compounds that enhance neuronal regeneration can lead to development of therapeutics to combat nervous system injuries and neurodegenerative diseases. By combining high-throughput microfluidics and femto
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d4ce9ab974e226ef99bb0bfa478e2d03
https://pubmed.ncbi.nlm.nih.gov/20937901
https://pubmed.ncbi.nlm.nih.gov/20937901
Autor:
Shu-Ching Huang, Tang K. Tang, Eva S. Liu, Stephanie Norton, Aeri Cho, Jennie Park, Edward J. Benz, Anyu Zhou, Alexander C. Ou, Amittha Wickrema, Guang Yang, Indira D. Munagala
Publikováno v:
Blood. 114(19)
The tightly regulated production of distinct erythrocyte protein 4.1R isoforms involves differential splicing of 3 mutually exclusive first exons (1A, 1B, 1C) to the alternative 3′ splice sites (ss) of exon 2′/2. Here, we demonstrate that exon 1
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8329870e757f314eddbe7718819f7d0a
https://pubmed.ncbi.nlm.nih.gov/19729518
https://pubmed.ncbi.nlm.nih.gov/19729518
Autor:
Robert Mayer, Eric Schenk, Sally Child, Stephanie Norton, Christine Cox, Carol Hartman, Christopher Cox, Edwin Carstensen
Publikováno v:
Journal of Urology. 144:1505-1509
Studies were performed with an interest in determining a pressure threshold for extracorporeal shock wave induced renal damage. Histological evidence of intraparenchymal hemorrhage was used as an indicator of tissue trauma. Depilated C3H mice were an
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9aa121df4f09c459e9c54998f4ae65b9
https://doi.org/10.1016/s0022-5347(17)39787-2
https://doi.org/10.1016/s0022-5347(17)39787-2