Zobrazeno 1 - 2
of 2
pro vyhledávání: '"Stephanie McClain"'
Autor:
Anne Taylor, Charles J. Mcintyre, Christine Fandozzi, Carolyn McHale, Jillian DiMuzio, Steven Harper, Steven S. Carroll, Vincenzo Summa, Jeff Fritzen, Aileen Soriano, Marco Ferrara, Joseph J. Romano, David B. Olsen, Kevin Nguyen, Steven W. Ludmerer, Nigel J. Liverton, Robert Chase, Stuart Black, John W. Butcher, Kevin F. Gilbert, Qian Huang, Michael T. Rudd, Adam Gates, Paul J. Coleman, Marcello DiFilippo, Mark Stahlhut, Kimberly J. Bush, John Swestock, Nicole Trainor, Christine Burlein, Stephanie McClain, John A. McCauley, M. Katharine Holloway, Donald J. Graham
Publikováno v:
ChemMedChem. 10:727-735
With the goal of identifying inhibitors of hepatitis C virus (HCV) NS3/4a protease that are potent against a wide range of genotypes and clinically relevant mutant viruses, several subseries of macrocycles were investigated based on observations made
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e9e23e37fb44618a041512672388b2e3
https://doi.org/10.1002/cmdc.201402558
https://doi.org/10.1002/cmdc.201402558
Autor:
John A. McCauley, Kevin Nguyen, Anne Taylor, Joseph J. Romano, Steven S. Carroll, Nicole Trainor, Qian Huang, Stephanie McClain, M. Katharine Holloway, Joseph P. Vacca, Jillian DiMuzio, Christine Burlein, Christine Fandozzi, Carolyn McHale, Vincenzo Summa, Michael Rowley, John W. Butcher, Nigel J. Liverton, Charles J. Mcintyre, Adam Gates, Bang-Lin Wan, Michael T. Rudd, Donald J. Graham, Steven Harper, David B. Olsen, Terry A. Lyle, Kevin F. Gilbert, Mark Stahlhut, Kimberly J. Bush, Steven W. Ludmerer
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 22:7207-7213
A series of macrocyclic compounds containing a cyclic constraint in the P2–P4 linker region have been discovered and shown to exhibit excellent HCV NS3/4a genotype 3a and genotype 1b R155 K, A156T, A156 V, and D168 V mutant activity while maintaini
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cddb557fdc755adc3a67b410d163da85
https://doi.org/10.1016/j.bmcl.2012.09.061
https://doi.org/10.1016/j.bmcl.2012.09.061