Zobrazeno 1 - 10
of 26
pro vyhledávání: '"Stephanie M.C. Smith"'
Autor:
BaoHan T. Vo, Chunliang Li, Marc A. Morgan, Ilan Theurillat, David Finkelstein, Shaela Wright, Judith Hyle, Stephanie M.C. Smith, Yiping Fan, Yong-Dong Wang, Gang Wu, Brent A. Orr, Paul A. Northcott, Ali Shilatifard, Charles J. Sherr, Martine F. Roussel
Publikováno v:
Cell Reports, Vol 18, Iss 12, Pp 2907-2917 (2017)
The most aggressive of four medulloblastoma (MB) subgroups are cMyc-driven group 3 (G3) tumors, some of which overexpress EZH2, the histone H3K27 mono-, di-, and trimethylase of polycomb-repressive complex 2. Ezh2 has a context-dependent role in diff
Externí odkaz:
https://doaj.org/article/8cdc8a025d034ff08042a4e43e4b4c04
Autor:
Maria Nikodemova, Alissa L. Small, Stephanie M.C. Smith, Gordon S. Mitchell, Jyoti J. Watters
Publikováno v:
Neurobiology of Disease, Vol 69, Iss , Pp 43-53 (2014)
Activation of microglia, CNS resident immune cells, is a pathological hallmark of amyotrophic lateral sclerosis (ALS), a neurodegenerative disorder affecting motor neurons. Despite evidence that microglia contribute to disease progression, the exact
Externí odkaz:
https://doaj.org/article/720e672e390f48b8bd6bafcd0f180622
Publikováno v:
ASN Neuro, Vol 6 (2014)
Our understanding of how histone demethylation contributes to the regulation of basal gene expression in the brain is largely unknown in any injury model, and especially in the healthy adult brain. Although Jumonji genes are often regulated transcrip
Externí odkaz:
https://doaj.org/article/38784b0b0b8c4f6a8048f24c9e4893bf
Autor:
Fiona Pakiam, Emily J. Girard, Ken Brasel, Erin E. Crotty, Yamicia D. Connor, Andrew J. Mhyre, Frederique Zindy, Stephanie M.C. Smith, James M. Olson, Martine F. Roussel
Publikováno v:
J Neurooncol
PURPOSE: Tumor infiltration by immunosuppressive myeloid cells or tumor-associated macrophages (TAMs) contributes to tumor progression and metastasis. In contrast to their adult counterparts, higher TAM signatures do not correlate with aggressive tum
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c96891dab0182433afe322c08f1c5d92
https://doi.org/10.1007/s11060-021-03767-x
https://doi.org/10.1007/s11060-021-03767-x
Autor:
Tyler K. Ulland, Stephanie M.C. Smith, Andrew O Knutson, Kaitlyn M. Marino, Jyoti J. Watters, Andrea C Ewald
Publikováno v:
Cells, Vol 10, Iss 2907, p 2907 (2021)
Cells
Cells
Sleep Disordered Breathing (SDB) and Alzheimer’s Disease (AD) are strongly associated clinically, but it is unknown if they are mechanistically associated. Here, we review data covering both the cellular and molecular responses in SDB and AD with a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::05311917bc14db5b2da376d9e4306806
https://www.mdpi.com/2073-4409/10/11/2907
https://www.mdpi.com/2073-4409/10/11/2907
Autor:
Christopher L. Tinkle, Thomas E. Merchant, Gretchen Harknett, Brandon Bianski, Richard J. Gilbertson, Martine F. Roussel, Brent A. Orr, Stephanie M.C. Smith, Arzu Onar-Thomas
Publikováno v:
International Journal of Radiation Oncology*Biology*Physics. 103:728-737
Purpose Craniospinal irradiation (CSI) is a crucial component of treatment for medulloblastoma (MB), a brain tumor clinically stratified into prognostically distinct molecular subgroups. Preclinical models of clinically relevant CSI offer the potenti
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7f57a5cd5f4f834664f48fa3b56c4f20
https://doi.org/10.1016/j.ijrobp.2018.10.015
https://doi.org/10.1016/j.ijrobp.2018.10.015
Autor:
Paul A. Northcott, Charles J. Sherr, Judith Hyle, Bao Han T. Vo, Yiping Fan, Martine F. Roussel, Shaela Wright, Ilan Theurillat, Ali Shilatifard, Yong Dong Wang, Brent A. Orr, David Finkelstein, Marc A. Morgan, Stephanie M.C. Smith, Chunliang Li, Gang Wu
Publikováno v:
Cell Reports, Vol 18, Iss 12, Pp 2907-2917 (2017)
The most aggressive of four medulloblastoma (MB) subgroups are cMyc-driven group 3 (G3) tumors, some of which overexpress EZH2, the histone H3K27 mono-, di-, and trimethylase of polycomb-repressive complex 2. Ezh2 has a context-dependent role in diff
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8cf805e57e1b6026d219fc3321ccdad3
Autor:
Jiao Zhang, Andrew S. Potter, W. Clay Gustafson, Liguo Zhang, Feng Zhang, Scott L. Pomeroy, Maryam Fouladi, Martine F. Roussel, Allison Pribnow, Xuezhao Liu, Michael D. Taylor, Kalen P. Berry, Q. Richard Lu, Lingli Xu, Blaise V. Jones, Christine Fuller, Maria C. Vladoiu, James M. Olson, Emily J. Girard, Weidong Tian, Marc Remke, Tao Zheng, S. Steven Potter, Xuelian He, Mei Xin, Wenhao Zhou, A. Sorana Morrissy, Rachid Drissi, Zaili Luo, Stephanie M.C. Smith, William A. Weiss, L. Frank Huang, Zeng-Jie Yang
Publikováno v:
Cancer cell, vol 36, iss 3
Progenitor heterogeneity and identities underlying tumor initiation and relapse in medulloblastomas remain elusive. Utilizing single-cell transcriptomic analysis, we demonstrated a developmental hierarchy of progenitor pools in Sonic Hedgehog (SHH) m
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ee6cd3b807a13a19f730a2d015800b92
https://escholarship.org/uc/item/23s294wx
https://escholarship.org/uc/item/23s294wx
Publikováno v:
The Journal of Physiology. 594:1563-1577
Chronic intermittent hypoxia (CIH) is a hallmark of sleep apnoea, a condition associated with diverse clinical disorders. CIH and sleep apnoea are characterized by increased reactive oxygen species formation, peripheral and CNS inflammation, neuronal
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::8cf7dca370f9fcd8569de51bd54939d4
https://doi.org/10.1113/jp271502
https://doi.org/10.1113/jp271502
Autor:
Richard J. Gilbertson, Victoria Morel, Giles W. Robinson, Brandon Bianski, Christopher L. Tinkle, Thomas E. Merchant, Stephanie M.C. Smith, Brent A. Orr, Martine F. Roussel, Amar Gajjar, Birgit Nimmervoll
Medulloblastoma (MB) is the most common malignant pediatric brain tumor that comprises four major subgroups. Group 3 (MBGrp3) that overexpress MYC and Sonic hedgehog (MBSHH) with MYCN amplification and TP53 loss of function have a particularly poor p
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1ab1fe65ae7c1916ee5219e5deb7d9e7
https://europepmc.org/articles/PMC5475156/
https://europepmc.org/articles/PMC5475156/