Zobrazeno 1 - 6
of 6
pro vyhledávání: '"Stephanie M. Nelson"'
Publikováno v:
Expert Opinion on Therapeutic Targets. 9:471-489
DNA-interacting anticancer drugs are able to affect the propensity of DNA to interact with proteins through either reversible binding or covalent bond formation. The effect of the drugs on transcription factor interactions with DNA is reviewed. These
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b0811d17dfc2dbe1b37b7e7d04d73f02
https://doi.org/10.1517/14728222.9.3.471
https://doi.org/10.1517/14728222.9.3.471
Publikováno v:
Mutation research. 623(1-2)
An understanding of the mechanism by which minor groove binding agents interact with DNA has led to the design of agents that can reversibly bind with high selectivity to extended DNA target sequences. Simple compounds, such as the polypyrroles and t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2953c8b221a4848a7d722a06716cad0e
https://pubmed.ncbi.nlm.nih.gov/17507044
https://pubmed.ncbi.nlm.nih.gov/17507044
Publikováno v:
Chemical research in toxicology. 18(2)
Aminoindolines, analogues of the potent DNA alkylating agent seco-CBI-TMI, bind to and alkylate in the minor groove of AT-rich DNA in vitro. Here we extend the in vitro mechanism of action studies by treating cells in culture and examining the DNA bi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e8b4e95d654a577ef6732a53deba7b2b
https://pubmed.ncbi.nlm.nih.gov/15720128
https://pubmed.ncbi.nlm.nih.gov/15720128
Publikováno v:
Cell & Chromosome
The nucleus of the cell serves to maintain, regulate, and replicate the critical genetic information encoded by the genome. Genomic DNA is highly associated with proteins that enable simple nuclear structures such as nucleosomes to form higher-order
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::96a76ec8386e38ec3f3afb21a9c5b40f
https://pubmed.ncbi.nlm.nih.gov/15157277
https://pubmed.ncbi.nlm.nih.gov/15157277
Publikováno v:
Current medicinal chemistry. 10(11)
Gene expression, both tissue specific or inducible, is controlled at the level of transcription by various transcription factors interacting with specific sequences of DNA. Anticancer drugs and other potential therapeutic agents alter interactions of
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f5c5fc5f11b1f428822acd96d3ab1bda
https://pubmed.ncbi.nlm.nih.gov/12678680
https://pubmed.ncbi.nlm.nih.gov/12678680
Publikováno v:
Cell & Chromosome. 3:2
The nucleus of the cell serves to maintain, regulate, and replicate the critical genetic information encoded by the genome. Genomic DNA is highly associated with proteins that enable simple nuclear structures such as nucleosomes to form higher-order
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::8ac0a1915a1dd05a59d2a5d3d648bcc0
https://doi.org/10.1186/1475-9268-3-2
https://doi.org/10.1186/1475-9268-3-2