Zobrazeno 1 - 10
of 23
pro vyhledávání: '"Stephanie M. Kereliuk"'
Autor:
Billy Vuong, Gary Odero, Stephanie Rozbacher, Mackenzie Stevenson, Stephanie M. Kereliuk, Troy J. Pereira, Vernon W. Dolinsky, Tiina M. Kauppinen
Publikováno v:
Journal of Neuroinflammation, Vol 14, Iss 1, Pp 1-13 (2017)
Abstract Background Birth cohort studies link gestational diabetes mellitus (GDM) with impaired cognitive performance in the offspring. However, the mechanisms involved are unknown. We tested the hypothesis that obesity-associated GDM induces chronic
Externí odkaz:
https://doaj.org/article/fcc3a52af2844cb3a23d07726dd32b70
Autor:
Mateusz M. Tomczyk, Kyle G. Cheung, Bo Xiang, Nahid Tamanna, Ana L. Fonseca Teixeira, Prasoon Agarwal, Stephanie M. Kereliuk, Victor Spicer, Ligen Lin, Jason Treberg, Qiang Tong, Vernon W. Dolinsky
Publikováno v:
Circulation: Heart Failure. 15
Background: High doses of doxorubicin put cancer patients at risk for developing dilated cardiomyopathy. Previously, we showed that doxorubicin treatment decreases SIRT3 (sirtuin 3), the main mitochondrial deacetylase and increases protein acetylatio
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::35dc39e9041ae79eb456cadc3e9aa1f3
https://doi.org/10.1161/circheartfailure.121.008547
https://doi.org/10.1161/circheartfailure.121.008547
Publikováno v:
International journal of molecular sciences. 23(8)
Globally, cardiovascular disease remains the leading cause of death. Most concerning is the rise in cardiovascular risk factors including obesity, diabetes and hypertension among youth, which increases the likelihood of the development of earlier and
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f60e997e59a5101acd406118297292e1
https://pubmed.ncbi.nlm.nih.gov/35457285
https://pubmed.ncbi.nlm.nih.gov/35457285
Autor:
Vernon W. Dolinsky, Simone C. da Silva Rosa, Saeid Ghavami, Christof Rampitsch, Lucas Nguyen, James A. Thliveris, Matthew D. Martens, Donald Chapman, Joseph W. Gordon, Adrian R. West, Stephanie M. Kereliuk, Yan Hai, Jared T. Field, William Diehl-Jones, Michel Aliani
Publikováno v:
Autophagy
article-version (VoR) Version of Record
article-version (VoR) Version of Record
Lipotoxicity is a form of cellular stress caused by the accumulation of lipids resulting in mitochondrial dysfunction and insulin resistance in muscle. Previously, we demonstrated that the mitophagy receptor BNIP3L/Nix is responsive to lipotoxicity a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c598ae3b4f6203556889028fbb2e0e46
https://doi.org/10.1080/15548627.2020.1821548
https://doi.org/10.1080/15548627.2020.1821548
Autor:
Vernon W. Dolinsky, Jonathan McGavock, Prasoon Agarwal, Stephanie M. Kereliuk, Grant M. Hatch, Laura K. Cole, Mario Fonseca, Gabriel Brawerman, Bo Xiang
Publikováno v:
Circulation Research. 129
Through unknown mechanisms, fetal exposure to gestational diabetes mellitus (GDM) increases the risk for cardiovascular disease development later in life. We hypothesize that fetal exposure to GDM alters offspring cardiomyocyte metabolism and left ve
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::a727abb24def79c96b51944466bb36f9
https://doi.org/10.1161/res.129.suppl_1.mp237
https://doi.org/10.1161/res.129.suppl_1.mp237
Autor:
Stephanie M. Kereliuk, Arun Surendran, Amir Ravandi, Mateusz M. Tomczyk, Vernon W. Dolinsky, Prasoon Agarwal, Qiang Tong, Kyle G. Cheung, Bo Xiang
Publikováno v:
Circulation Research. 129
Doxorubicin (DOX) is a chemotherapeutic with dose-dependent cardiotoxic effects that limits its use in patients. Previously we showed that DOX decreases expression of the mitochondrial lysine deacetylase SIRT3 in the mouse heart. We hypothesize that
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::57708b0312d477e65aaf51df111b306d
https://doi.org/10.1161/res.129.suppl_1.p425
https://doi.org/10.1161/res.129.suppl_1.p425
Autor:
Grant M. Hatch, Mario Fonseca, Bo Xiang, Laura K. Cole, Troy J. Pereira, Navdeep Brar, Gabriel Brawerman, Stephanie M. Kereliuk, Vernon W. Dolinsky, Kristin Hunt, Christine A. Doucette, Nivedita Seshadri
Publikováno v:
The Journal of Physiology. 597:4175-4192
Key points Maternal resveratrol (RESV) administration in gestational diabetes (GDM) restored normoglycaemia and insulin secretion. GDM-induced obesity was prevented in male GDM+RESV offspring but not in females. GDM+RESV offspring exhibited improved
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dc2c1d4d5909851a9e1239dcbe011b64
https://doi.org/10.1113/jp278082
https://doi.org/10.1113/jp278082
Autor:
Mario Fonseca, Prasoon Agarwal, Christine A. Doucette, Bo Xiang, Vernon W. Dolinsky, Grant M. Hatch, Stephanie M. Kereliuk, Kristin Hunt, Taylor Morriseau, Nivedita Seshadri, Navdeep Brar, Aruni Jha, Laura K. Cole
Publikováno v:
Endocrinology
Fetal exposure to gestational diabetes mellitus (GDM) and poor postnatal diet are strong risk factors for type 2 diabetes development later in life, but the mechanisms connecting GDM exposure to offspring metabolic health remains unclear. In this stu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::97aa0b1753632f96dc30d5efb6991107
https://doi.org/10.1210/en.2019-00232
https://doi.org/10.1210/en.2019-00232
Autor:
Vernon W. Dolinsky, Laura K. Cole, Bo Xiang, Mario Fonseca, Prasoon Agarwal, Grant M. Hatch, Stephanie M. Kereliuk, Jonathan McGavock, Gabriel Brawerman
Publikováno v:
Circulation Research. 127
Through unknown mechanisms, fetal exposure to gestational diabetes mellitus (GDM) increases the risk for cardiovascular disease development later in life. We hypothesize that fetal exposure to GDM induces alterations in cardiomyocyte metabolism and i
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::3045f1b03a2d8f09525506c12b18e0fc
https://doi.org/10.1161/res.127.suppl_1.242
https://doi.org/10.1161/res.127.suppl_1.242
Autor:
Wajihah Mughal, Matthew Martens, Donald Chapman, Yan Hai, Joseph W. Gordon, Vernon W. Dolinsky, Adrian R. West, Laura K. Cole, Kyle G. Cheung, William Diehl-Jones, Jared T. Field, Ian M.C. Dixon, Sunil G. Rattan, Richard Keijzer, Stephanie M. Kereliuk, Michael S. Parmacek, Jianhe Huang, Grant M. Hatch
Publikováno v:
Cell Death and Differentiation
Myocardin is a transcriptional co-activator required for cardiovascular development, but also promotes cardiomyocyte survival through an unclear molecular mechanism. Mitochondrial permeability transition is implicated in necrosis, while pore closure
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9bc780893cc302e53c6b6f47df559c32
http://europepmc.org/articles/PMC6180099
http://europepmc.org/articles/PMC6180099