Zobrazeno 1 - 10
of 14
pro vyhledávání: '"Stephanie M. Hu"'
Autor:
Stephanie M. Hu, Steven Horng, Seth J. Berkowitz, Ruizhi Liao, Rahul G. Krishnan, Li-wei H. Lehman, Roger G. Mark
Accurately assessing the severity of pulmonary edema is critical for making treatment decisions in congestive heart failure patients. However, the current scale for quantifying pulmonary edema based on chest radiographs does not have well-characteriz
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::7fdfaa752ad0bc8012aec9a2ed4664ed
https://doi.org/10.1101/2022.01.15.22269345
https://doi.org/10.1101/2022.01.15.22269345
Autor:
Kirstin O. McDonald, Nikita M. A. Lyons, Luca K. C. Gray, Janet B. Xu, Lucia Schoderboeck, Stephanie M. Hughes, Indranil Basak
Publikováno v:
Cells, Vol 13, Iss 12, p 1016 (2024)
Dopaminergic neurons are the predominant brain cells affected in Parkinson’s disease. With the limited availability of live human brain dopaminergic neurons to study pathological mechanisms of Parkinson’s disease, dopaminergic neurons have been g
Externí odkaz:
https://doaj.org/article/9dd4689e35f045f190896ade8ce2164e
Autor:
Joshua T. Dearborn, Hemanth R. Nelvagal, Nicholas R. Rensing, Keigo Takahashi, Stephanie M. Hughes, Thomas M. Wishart, Jonathan D. Cooper, Michael Wong, Mark S. Sands
Publikováno v:
Scientific Reports, Vol 12, Iss 1, Pp 1-13 (2022)
Abstract Cannabidiol (CBD) has gained attention as a therapeutic agent and is purported to have immunomodulatory, neuroprotective, and anti-seizure effects. Here, we determined the effects of chronic CBD administration in a mouse model of CLN1 diseas
Externí odkaz:
https://doaj.org/article/350eddea052f435687b37a8c0940ae75
Autor:
Leon C. D. Smyth, Helen C. Murray, Madison Hill, Eve van Leeuwen, Blake Highet, Nicholas J. Magon, Mahyar Osanlouy, Sophie N. Mathiesen, Bruce Mockett, Malvindar K. Singh-Bains, Vanessa K. Morris, Andrew N. Clarkson, Maurice A. Curtis, Wickliffe C. Abraham, Stephanie M. Hughes, Richard L. M. Faull, Anthony J. Kettle, Mike Dragunow, Mark B. Hampton
Publikováno v:
Acta Neuropathologica Communications, Vol 10, Iss 1, Pp 1-17 (2022)
Abstract Introduction Neutrophil accumulation is a well-established feature of Alzheimer’s disease (AD) and has been linked to cognitive impairment by modulating disease-relevant neuroinflammatory and vascular pathways. Neutrophils express high lev
Externí odkaz:
https://doaj.org/article/4881c6c2cd424db9be6a4d32261c425f
Autor:
Shane M. Ohline, Connie Chan, Lucia Schoderboeck, Hollie E. Wicky, Warren P. Tate, Stephanie M. Hughes, Wickliffe C. Abraham
Publikováno v:
Molecular Brain, Vol 15, Iss 1, Pp 1-18 (2022)
Abstract Soluble amyloid precursor protein-alpha (sAPPα) is a regulator of neuronal and memory mechanisms, while also having neurogenic and neuroprotective effects in the brain. As adult hippocampal neurogenesis is impaired in Alzheimer’s disease,
Externí odkaz:
https://doaj.org/article/34bce049805343a4889650cc7524a1b1
Autor:
Indranil Basak, Rhodri Harfoot, Jennifer E. Palmer, Abhishek Kumar, Miguel E. Quiñones-Mateu, Lucia Schweitzer, Stephanie M. Hughes
Publikováno v:
Biomolecules, Vol 13, Iss 11, p 1597 (2023)
Besides respiratory illness, SARS-CoV-2, the causative agent of COVID-19, leads to neurological symptoms. The molecular mechanisms leading to neuropathology after SARS-CoV-2 infection are sparsely explored. SARS-CoV-2 enters human cells via different
Externí odkaz:
https://doaj.org/article/33a8e727070a44c79a7916f37f242ce7
Autor:
Sophie N. Mathiesen, Jasmine L. Lock, Lucia Schoderboeck, Wickliffe C. Abraham, Stephanie M. Hughes
Publikováno v:
Molecular Therapy: Methods & Clinical Development, Vol 19, Iss , Pp 447-458 (2020)
Adeno-associated viral (AAV) vectors are attractive tools for central nervous system (CNS) gene therapy because some vectors can cross the blood-brain barrier (BBB), allowing them to be used as minimally invasive treatments. A novel AAV vector recent
Externí odkaz:
https://doaj.org/article/8ef64cc3e9cc4b138ce8773bc9af7587
Autor:
Valerie T. Y. Tan, Bruce G. Mockett, Shane M. Ohline, Karen D. Parfitt, Hollie E. Wicky, Katie Peppercorn, Lucia Schoderboeck, Mohamad Fairuz bin Yahaya, Warren P. Tate, Stephanie M. Hughes, Wickliffe C. Abraham
Publikováno v:
Molecular Brain, Vol 11, Iss 1, Pp 1-16 (2018)
Abstract Alzheimer’s disease (AD) is a neurodegenerative disease driven in large part by accumulated deposits in the brain of the amyloid precursor protein (APP) cleavage product amyloid-β peptide (Aβ). However, AD is also characterised by reduct
Externí odkaz:
https://doaj.org/article/829842a4c1ec4ba690c8af863cc84017
Publikováno v:
Biomolecules, Vol 11, Iss 10, p 1412 (2021)
Batten disease is a devastating, childhood, rare neurodegenerative disease characterised by the rapid deterioration of cognition and movement, leading to death within ten to thirty years of age. One of the thirteen Batten disease forms, CLN5 Batten d
Externí odkaz:
https://doaj.org/article/74b179507b184d9c97a40dbf54c81f06
Autor:
Jodi A. Morrissey, Erin Bigus, Julie C. Necarsulmer, Vinay Srinivasan, Katie Peppercorn, Daniel J. O’Leary, Bruce G. Mockett, Warren P. Tate, Stephanie M. Hughes, Karen D. Parfitt, Wickliffe C. Abraham
Publikováno v:
Frontiers in Cellular Neuroscience, Vol 13 (2019)
Secreted amyloid precursor protein-alpha (sAPPα), generated by enzymatic processing of the APP, possesses a range of neurotrophic and neuroprotective properties and plays a critical role in the molecular mechanisms of memory and learning. One of the
Externí odkaz:
https://doaj.org/article/17c333daa54044fa944310ae25f4bb81