Zobrazeno 1 - 10
of 21
pro vyhledávání: '"Stephanie M. Cabarcas"'
Cryptotanshinone targets tumor-initiating cells through down-regulation of stemness genes expression
Autor:
Jia-Bin Zheng, Xiaohu Zhang, Ying Zhang, Lesley A. Mathews, Hongsheng Lin, Stephanie M. Cabarcas, Lei Sun, William L. Farrar
Publikováno v:
Oncology Letters. 11:3803-3812
Recent evidence indicates that tumor-initiating cells (TICs), also called cancer stem cells (CSCs), are responsible for tumor initiation and progression, therefore representing an important cell population that may be used as a target for the develop
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4185d81099050598156cfe29e9c959c8
https://doi.org/10.3892/ol.2016.4444
https://doi.org/10.3892/ol.2016.4444
Autor:
Lesley A. Mathews, Stephanie M. Cabarcas, Lei Sun, William L. Farrar, Suneetha B. Thomas, Xiaohu Zhang
Publikováno v:
Pancreas. 42:861-870
Objective Pancreatic cancer is a leading cancer type and its molecular pathology is poorly understood. The only potentially curative therapeutic option available is complete surgical resection; however, this is inadequate as most of the patients are
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::94ef31c250a4fbe063a7a70d41acbc98
https://doi.org/10.1097/mpa.0b013e318279d568
https://doi.org/10.1097/mpa.0b013e318279d568
Autor:
Elaine M. Hurt, James Cherry, Stephanie M. Cabarcas, Eric Lader, Xiaohu Zhang, Thomas Sebastian, William L. Farrar, Subu Yerramilli, Suneetha B. Thomas
Publikováno v:
Genomics. 99(2):108-117
TICs are characterized by their ability to self-renew, differentiate and initiate tumor formation. miRNAs are small noncoding RNAs that bind to mRNAs resulting in regulation of gene expression and biological functions. The role of miRNAs and TICs in
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2053e43868391a4a006f9d3d36935249
Publikováno v:
International Journal of Cancer. 129:2315-2327
The niche is the environment in which stem cells reside and is responsible for the maintenance of unique stem cell properties such as self-renewal and an undifferentiated state. The heterogeneous populations which constitute a niche include both stem
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::994144b6f02867037a4bd30a196557f4
https://doi.org/10.1002/ijc.26312
https://doi.org/10.1002/ijc.26312
Autor:
Lesley A. Mathews, Stephanie M. Cabarcas, Elaine M. Hurt, William L. Farrar, Xiaohu Zhang, Elizabeth M. Jaffee
Publikováno v:
Pancreas. 40:730-739
OBJECTIVE Pancreatic cancer was the fourth leading cause of cancer death in the United States in 2010. Recurrence of disease after resection occurs because of neoplastic cell survival. To better understand these highly aggressive cells, gene expressi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3241d9bd94e6c8c9ba933f438aeb4492
https://doi.org/10.1097/mpa.0b013e31821ae25b
https://doi.org/10.1097/mpa.0b013e31821ae25b
Publikováno v:
Cancer Metastasis Reviews
The existence of “tumor-initiating cells” (TICs) has been a topic of heated debate for the last few years within the field of cancer biology. Their continuous characterization in a variety of solid tumors has led to an abundance of evidence suppo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3dc4d324fea1f54af45f31c57896b384
http://europepmc.org/articles/PMC3078299
http://europepmc.org/articles/PMC3078299
Publikováno v:
Current Molecular Medicine. 10:741-755
The metabolic syndrome is characterized by a state of metabolic dysfunction resulting in the development of several chronic diseases that are potentially deadly. These metabolic deregulations are complex and intertwined and it has been observed that
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6b2f23a2e2b1ca1ce636afd9a57cd8c8
https://doi.org/10.2174/156652410793384187
https://doi.org/10.2174/156652410793384187
Publikováno v:
OnLine Journal of Biological Sciences. 10:114-125
Problem statement: RNA polymerase III (RNA pol III) is responsible for transcribing many of the small structural RNA molecules involved in RNA processing and protein translation, thereby regulating the growth rate of a cell. RNA pol III transcribes b
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d6e3a12f77a4718651a7741f4d031313
https://doi.org/10.3844/ojbsci.2010.114.125
https://doi.org/10.3844/ojbsci.2010.114.125
Publikováno v:
Scopus-Elsevier
International Journal of Biological Sciences
International Journal of Biological Sciences
RNA polymerase III (RNA pol III) transcribes many of the small structural RNA molecules involved in processing and translation, thereby regulating the growth rate of a cell. Initiation of pol III transcription requires the evolutionarily conserved po
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0a9fd7dbadc4b5a047eb41e844f3e83e
https://doi.org/10.7150/ijbs.3.292
https://doi.org/10.7150/ijbs.3.292
The existence of ‘cancer stem cells'(CSCs) has been a topic of heated debate for the last few years within the field of cancer biology. Their continuous characterization in a variety of solid tumors has lead to an abundance of evidence supporting t
