Zobrazeno 1 - 10
of 53
pro vyhledávání: '"Stephanie M. Stanford"'
Autor:
John F. Imbery, Celina Wiik, Julia Heinzelbecker, Jenny K. Jebsen, Mia K. Dobbing, Nunzio Bottini, Stephanie M. Stanford, Ludvig A. Munthe, Geir E. Tjønnfjord, Anders Tveita, Peter Szodoray, Britt Nakken
Publikováno v:
Molecular Therapy: Oncology, Vol 32, Iss 3, Pp 200841- (2024)
Chronic lymphocytic leukemia (CLL) growth is dependent on both B cell receptor (BCR) signaling and signals from microenvironmental T helper (Th) cells. We previously described a mechanism where Th cells enhance BCR signaling and proliferation through
Externí odkaz:
https://doaj.org/article/dccaffd146a34de9944a3fd659392210
Autor:
Peter Szodoray, Tor Kristian Andersen, Julia Heinzelbecker, John F. Imbery, Peter C. Huszthy, Stephanie M. Stanford, Bjarne Bogen, Ole B. Landsverk, Nunzio Bottini, Anders Tveita, Ludvig A. Munthe, Britt Nakken
Publikováno v:
Cell Reports, Vol 36, Iss 6, Pp 109525- (2021)
Summary: Humoral immunity relies on the efficient differentiation of memory B cells (MBCs) into antibody-secreting cells (ASCs). T helper (Th) signals upregulate B cell receptor (BCR) signaling by potentiating Src family kinases through increasing CD
Externí odkaz:
https://doaj.org/article/eb782f741c90461f80cc29c4bb22a13b
Autor:
Stephanie M. Stanford, Nunzio Bottini
Publikováno v:
Nature Reviews Drug Discovery. 22:273-294
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::42e88c2dd89df5c21c4e1115524d1279
https://doi.org/10.1038/s41573-022-00618-w
https://doi.org/10.1038/s41573-022-00618-w
Autor:
Wan-Chen Hsieh, Mattias N.D. Svensson, Martina Zoccheddu, Michael L. Tremblay, Shimon Sakaguchi, Stephanie M. Stanford, Nunzio Bottini
Publikováno v:
JCI Insight, Vol 5, Iss 20 (2020)
Loss-of-function variants of protein tyrosine phosphatase non-receptor type 2 (PTPN2) enhance risk of inflammatory bowel disease and rheumatoid arthritis; however, whether the association between PTPN2 and autoimmune arthritis depends on gut inflamma
Externí odkaz:
https://doaj.org/article/65333424551d4eefb0163c129e129b95
Autor:
Cristiano Sacchetti, Yunpeng Bai, Stephanie M. Stanford, Paola Di Benedetto, Paola Cipriani, Eugenio Santelli, Sonsoles Piera-Velazquez, Vladimir Chernitskiy, William B. Kiosses, Arnold Ceponis, Klaus H. Kaestner, Francesco Boin, Sergio A. Jimenez, Roberto Giacomelli, Zhong-Yin Zhang, Nunzio Bottini
Publikováno v:
Nature Communications, Vol 8, Iss 1, Pp 1-14 (2017)
Although protein tyrosine kinases are being explored as antifibrotic agents for the treatment of systemic sclerosis, little is known about the function of counteractive protein tyrosine phosphatases in this context. Here, the authors show that PTP4A1
Externí odkaz:
https://doaj.org/article/bda2249f57354c398a9b7c97bc41a7fd
Autor:
Stephanie M. Stanford, Robert Ardecky, Zachary J. Holmes, Michael P Hedrick, Socorro Rodiles, Michael A. Diaz, April Guan, Tiffany P Nguyen, Stefan Grotegut, Jiwen Zou, Michael R. Jackson, Nunzio Bottini, Thomas D.Y. Chung, Eugenio Santelli, Anthony B. Pinkerton, Tarmo Roosild
Publikováno v:
J Med Chem
Obesity-associated insulin resistance plays a central role in the pathogenesis of type 2 diabetes. A promising approach to decrease insulin resistance in obesity is to inhibit the protein tyrosine phosphatases that negatively regulate insulin recepto
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8245f679ccb15ad5bc26c204df2f78d6
https://doi.org/10.1021/acs.jmedchem.0c02126
https://doi.org/10.1021/acs.jmedchem.0c02126
Autor:
Matthew R. Bliss, Vida Zhang, Alessia Lodi, Meghan Collins, Stephanie M. Stanford, Stefano Tiziani, Michael A. Diaz, Nunzio Bottini, Paul Gries, Zachary J. Holmes
Publikováno v:
J Cell Physiol
Obesity is a major contributing factor to the pathogenesis of Type 2 diabetes. Multiple human genetics studies suggest that high activity of the low molecular weight protein tyrosine phosphatase (LMPTP) promotes metabolic syndrome in obesity. We repo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9487f83c39da7eed3ac36449ddf3611e
https://doi.org/10.1002/jcp.30307
https://doi.org/10.1002/jcp.30307
Autor:
John F. Imbery, Julia Heinzelbecker, Jenny K. Jebsen, Marc McGowan, Camilla Myklebust, Nunzio Bottini, Stephanie M. Stanford, Sigrid S. Skånland, Anders Tveita, Geir E. Tjønnfjord, Ludvig A. Munthe, Peter Szodoray, Britt Nakken
Publikováno v:
British journal of haematology. 198(3)
Chronic lymphocytic leukaemia (CLL) is characterised by malignant mature-like B cells. Supportive to CLL cell survival is chronic B-cell receptor (BCR) signalling; however, emerging evidence demonstrates CLL cells proliferate in response to T-helper
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a58f6701dbcd718d9029292f1c8cfefa
https://pubmed.ncbi.nlm.nih.gov/35655388
https://pubmed.ncbi.nlm.nih.gov/35655388
Autor:
Kuninobu Wakabayashi, Nunzio Bottini, Mattias Svensson, Yutao Wen, Stephanie M. Stanford, Eugenio Santelli, Shen Yang
Publikováno v:
J Biol Chem
Receptor-type protein tyrosine phosphatase α (RPTPα) is an important positive regulator of SRC kinase activation and a known promoter of cancer growth, fibrosis, and arthritis. The domain structure of RPTPs comprises an extracellular region, a tran
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::30e06ac4e2c5d16bb02e40bf9ce7127f
https://doi.org/10.1074/jbc.ra119.011808
https://doi.org/10.1074/jbc.ra119.011808
Autor:
Erkan Kiris, Jonathan E Nuss, Stephanie M Stanford, Laura M Wanner, Lisa Cazares, Michael F Maestre, Hao T Du, Glenn Y Gomba, James C Burnett, Rick Gussio, Nunzio Bottini, Rekha G Panchal, Christopher D Kane, Lino Tessarollo, Sina Bavari
Publikováno v:
PLoS ONE, Vol 10, Iss 6, p e0129264 (2015)
There is an urgent need to develop novel treatments to counter Botulinum neurotoxin (BoNT) poisoning. Currently, the majority of BoNT drug development efforts focus on directly inhibiting the proteolytic components of BoNT, i.e. light chains (LC). Al
Externí odkaz:
https://doaj.org/article/60298f029db949189b12f9558abf609f