Zobrazeno 1 - 10
of 106
pro vyhledávání: '"Stephanie M Karst"'
Publikováno v:
mBio, Vol 14, Iss 4 (2023)
ABSTRACT As the largest mucosal surface, the gastrointestinal (GI) tract plays a key role in protecting the host against pathogen infections. It is a first line of defense against enteric viruses and must act to control infection while remaining tole
Externí odkaz:
https://doaj.org/article/205bcc074f614bf2aedfb97fc5dd4c0c
Autor:
Marco Grodzki, Andrew P. Bluhm, Moritz Schaefer, Abderrahmane Tagmount, Max Russo, Amin Sobh, Roya Rafiee, Chris D. Vulpe, Stephanie M. Karst, Michael H. Norris
Publikováno v:
Genome Medicine, Vol 14, Iss 1, Pp 1-18 (2022)
Abstract Background The COVID-19 pandemic has resulted in 275 million infections and 5.4 million deaths as of December 2021. While effective vaccines are being administered globally, there is still a great need for antiviral therapies as antigenicall
Externí odkaz:
https://doaj.org/article/0389603ba2a943b3a03f0bb2d378231d
Autor:
Emily W. Helm, Amy M. Peiper, Matthew Phillips, Caroline G. Williams, Michael B. Sherman, Theresa Kelley, Hong Q. Smith, Sorin O. Jacobs, Dhairya Shah, Sarah M. Tatum, Neha Iyer, Marco Grodzki, Joyce C. Morales Aparicio, Elizabeth A. Kennedy, Mikayla S. Manzi, Megan T. Baldridge, Thomas J. Smith, Stephanie M. Karst
Publikováno v:
Frontiers in Immunology, Vol 13 (2022)
Noroviruses are the leading cause of severe childhood diarrhea and foodborne disease worldwide. While they are a major cause of disease in all age groups, infections in the very young can be quite severe with annual estimates of 50,000-200,000 fatali
Externí odkaz:
https://doaj.org/article/977826bdb7f747619d7e66707745bdfc
Autor:
Carmen Mirabelli, Melissa K. Jones, Vivienne L. Young, Abimbola O. Kolawole, Irene Owusu, Mengrou Shan, Basel Abuaita, Holly Turula, Jose G. Trevino, Irina Grigorova, Steven K. Lundy, Costas A. Lyssiotis, Vernon K. Ward, Stephanie M. Karst, Christiane E. Wobus
Publikováno v:
mBio, Vol 13, Iss 2 (2022)
ABSTRACT Human norovirus (HNoV) is a global health and socioeconomic burden, estimated to infect every individual at least five times during their lifetime. The underlying mechanism for the potential lack of long-term immune protection from HNoV infe
Externí odkaz:
https://doaj.org/article/298a2a3779044a91988f0db58af882d8
Autor:
Alexa N. Roth, Emily W. Helm, Carmen Mirabelli, Erin Kirsche, Jonathan C. Smith, Laura B. Eurell, Sourish Ghosh, Nihal Altan-Bonnet, Christiane E. Wobus, Stephanie M. Karst
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-8 (2020)
Here the authors show that a murine norovirus causes self-resolving diarrhea in the absence of systemic disease in wild-type neonatal mice and show that lymphocytes affect disease in a dual manner. The data suggests that neonatal mice are a promising
Externí odkaz:
https://doaj.org/article/9a6932ec89e94268872ca25929c2bda7
Autor:
Forrest C Walker, Ebrahim Hassan, Stefan T Peterson, Rachel Rodgers, Lawrence A Schriefer, Cassandra E Thompson, Yuhao Li, Gowri Kalugotla, Carla Blum-Johnston, Dylan Lawrence, Broc T McCune, Vincent R Graziano, Larissa Lushniak, Sanghyun Lee, Alexa N Roth, Stephanie M Karst, Timothy J Nice, Jonathan J Miner, Craig B Wilen, Megan T Baldridge
Publikováno v:
PLoS Pathogens, Vol 17, Iss 3, p e1009402 (2021)
Interferons (IFNs) are key controllers of viral replication, with intact IFN responses suppressing virus growth and spread. Using the murine norovirus (MNoV) system, we show that IFNs exert selective pressure to limit the pathogenic evolutionary pote
Externí odkaz:
https://doaj.org/article/90fb07bf8a2e40fb883cfc49c1867b66
Autor:
Elizabeth A. Kennedy, Somya Aggarwal, Arko Dhar, Stephanie M. Karst, Craig B. Wilen, Megan T. Baldridge
Publikováno v:
Nature Microbiology.
Autor:
Amy M. Peiper, Emily W. Helm, Quyen Nguyen, Matthew Phillips, Caroline G. Williams, Dhairya Shah, Sarah Tatum, Neha Iyer, Marco Grodzki, Laura B. Eurell, Aqsa Nasir, Megan T. Baldridge, Stephanie M. Karst
Publikováno v:
Lab Animal.
Noroviruses are the leading cause of severe childhood diarrhea and foodborne disease worldwide. While they are a major cause of disease in all age groups, infections in the very young can be quite severe, with annual estimates of 50,000–200,000 fat
Autor:
Amy Davis, Valerie Cortez, Marco Grodzki, Ronald Dallas, Jose Ferrolino, Pamela Freiden, Gabriela Maron, Hana Hakim, Randall T. Hayden, Li Tang, Adam Huys, Abimbola O. Kolawole, Christiane E. Wobus, Melissa K. Jones, Stephanie M. Karst, Stacey Schultz-Cherry
Publikováno v:
Viruses, Vol 12, Iss 6, p 619 (2020)
Noroviruses are a leading cause of gastroenteritis worldwide. Although infections in healthy individuals are self-resolving, immunocompromised individuals are at risk for chronic disease and severe complications. Chronic norovirus infections in immun
Externí odkaz:
https://doaj.org/article/429f651a79324e8b8d240f1ca137d0a1
Autor:
Shu Zhu, Candace Barnes, Sutonuka Bhar, Papa Hoyeck, Annalise N. Galbraith, Divya Devabhaktuni, Stephanie M. Karst, Naim Montazeri, Melissa K. Jones
Publikováno v:
Viruses, Vol 12, Iss 4, p 461 (2020)
Human noroviruses are the leading cause of foodborne gastroenteritis worldwide and disease outbreaks have been linked to contaminated surface waters as well as to produce consumption. Noroviruses are extremely stable in water and their presence is be
Externí odkaz:
https://doaj.org/article/d94d2e20f2e0415bbbba4f715423a244