Zobrazeno 1 - 10
of 537
pro vyhledávání: '"Stephanie Le"'
Autor:
Pawel Lisowski, Selene Lickfett, Agnieszka Rybak-Wolf, Carmen Menacho, Stephanie Le, Tancredi Massimo Pentimalli, Sofia Notopoulou, Werner Dykstra, Daniel Oehler, Sandra López-Calcerrada, Barbara Mlody, Maximilian Otto, Haijia Wu, Yasmin Richter, Philipp Roth, Ruchika Anand, Linda A. M. Kulka, David Meierhofer, Petar Glazar, Ivano Legnini, Narasimha Swamy Telugu, Tobias Hahn, Nancy Neuendorf, Duncan C. Miller, Annett Böddrich, Amin Polzin, Ertan Mayatepek, Sebastian Diecke, Heidi Olzscha, Janine Kirstein, Cristina Ugalde, Spyros Petrakis, Sidney Cambridge, Nikolaus Rajewsky, Ralf Kühn, Erich E. Wanker, Josef Priller, Jakob J. Metzger, Alessandro Prigione
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-27 (2024)
Abstract Expansion of the glutamine tract (poly-Q) in the protein huntingtin (HTT) causes the neurodegenerative disorder Huntington’s disease (HD). Emerging evidence suggests that mutant HTT (mHTT) disrupts brain development. To gain mechanistic in
Externí odkaz:
https://doaj.org/article/340c015abcae4c679391b04ea77b6a41
Autor:
Laura Petersilie, Karl W. Kafitz, Louis A. Neu, Sonja Heiduschka, Stephanie Le, Alessandro Prigione, Christine R. Rose
Publikováno v:
STAR Protocols, Vol 5, Iss 3, Pp 103212- (2024)
Summary: Three-dimensional brain organoids from human pluripotent stem cells are a powerful tool for studying human neural networks. Here, we present a protocol for generating cortical brain organoid slices (cBOS) derived from regionalized cortical o
Externí odkaz:
https://doaj.org/article/1b1c2c848704492f8b2e916be127daec
Autor:
Isabel Paiva, Jonathan Seguin, Iris Grgurina, Akash Kumar Singh, Brigitte Cosquer, Damien Plassard, Laura Tzeplaeff, Stephanie Le Gras, Ludovica Cotellessa, Charles Decraene, Johanne Gambi, Rafael Alcala-Vida, Muthusamy Eswaramoorthy, Luc Buée, Jean-Christophe Cassel, Paolo Giacobini, David Blum, Karine Merienne, Tapas K. Kundu, Anne-Laurence Boutillier
Publikováno v:
Neurobiology of Disease, Vol 198, Iss , Pp 106538- (2024)
Aging is the main risk factor of cognitive neurodegenerative diseases such as Alzheimer's disease, with epigenome alterations as a contributing factor. Here, we compared transcriptomic/epigenomic changes in the hippocampus, modified by aging and by t
Externí odkaz:
https://doaj.org/article/f5714d9bc754442fab0e4c7aa97ead64
Autor:
Laura A. Wortinger, Anne-Kristin Stavrum, Alexey A. Shadrin, Attila Szabo, Sondre Høeg Rukke, Stener Nerland, Runar Elle Smelror, Kjetil Nordbø Jørgensen, Claudia Barth, Dimitrios Andreou, Melissa A. Weibell, Srdjan Djurovic, Ole A. Andreassen, Marianne Thoresen, Gianluca Ursini, Ingrid Agartz, Stephanie Le Hellard
Publikováno v:
Translational Psychiatry, Vol 14, Iss 1, Pp 1-12 (2024)
Abstract Epigenetic modifications influenced by environmental exposures are molecular sources of phenotypic heterogeneity found in schizophrenia and bipolar disorder and may contribute to shared etiopathogenetic mechanisms of these two disorders. New
Externí odkaz:
https://doaj.org/article/f24b9ca7483d42a982ec065218ae1ee7
Autor:
Laura Petersilie, Sonja Heiduschka, Joel S.E. Nelson, Louis A. Neu, Stephanie Le, Ruchika Anand, Karl W. Kafitz, Alessandro Prigione, Christine R. Rose
Publikováno v:
iScience, Vol 27, Iss 4, Pp 109415- (2024)
Summary: Brain organoids derived from human pluripotent stem cells are a promising tool for studying human neurodevelopment and related disorders. Here, we generated long-term cultures of cortical brain organoid slices (cBOS) grown at the air-liquid
Externí odkaz:
https://doaj.org/article/f83e373fe09e4483942951f1ce28e66a
Autor:
Leila Marie Frid, Ute Kessler, Olga Therese Ousdal, Åsa Hammar, Jan Haavik, Frank Riemer, Marco Hirnstein, Lars Ersland, Vera Jane Erchinger, Eivind Haga Ronold, Gyrid Nygaard, Petter Jakobsen, Alexander R. Craven, Berge Osnes, Renata Alisauskiene, Hauke Bartsch, Stephanie Le Hellard, Anne-Kristin Stavrum, Ketil J. Oedegaard, Leif Oltedal
Publikováno v:
BMC Psychiatry, Vol 23, Iss 1, Pp 1-13 (2023)
Abstract Background Noninvasive neurostimulation treatments are increasingly being used to treat major depression, which is a common cause of disability worldwide. While electroconvulsive therapy (ECT) and transcranial magnetic stimulation (TMS) are
Externí odkaz:
https://doaj.org/article/1505209c9ea640909735dc1347a4324e
Autor:
Jonelle D. Villar, Anne-Kristin Stavrum, Leticia M. Spindola, Anja Torsvik, Thomas Bjella, Niels Eiel Steen, Srdjan Djurovic, Ole A. Andreassen, Vidar M. Steen, Stephanie Le Hellard
Publikováno v:
Translational Psychiatry, Vol 13, Iss 1, Pp 1-7 (2023)
Abstract Cases with schizophrenia (SCZ) and healthy controls show differences in white blood cell (WBC) counts and blood inflammation markers. Here, we investigate whether time of blood draw and treatment with psychiatric medications are related to d
Externí odkaz:
https://doaj.org/article/846646a26ed14d26910867ff1b825a8b
Autor:
Kristen Hagen, Stian Solem, Anne Kristin Stavrum, Jarle Eid, Gerd Kvale, Oddrun Samdal, Stephanie Le Hellard
Publikováno v:
Cogent Psychology, Vol 10, Iss 1 (2023)
AbstractThe main objective of the study was to investigate changes in mental health symptoms from the start of the pandemic in Norway (April) to December 2020. A total of 6017 participants completed an assessment of the survey at both time points. Ma
Externí odkaz:
https://doaj.org/article/e8de25106931447aa3deaf9d2cf75098
Super-enhancer-driven expression of BAHCC1 promotes melanoma cell proliferation and genome stability
Autor:
Pietro Berico, Maguelone Nogaret, Max Cigrang, Antonin Lallement, Fatemeh Vand-Rajabpour, Amanda Flores-Yanke, Giovanni Gambi, Guillaume Davidson, Leane Seno, Julian Obid, Bujamin H. Vokshi, Stephanie Le Gras, Gabrielle Mengus, Tao Ye, Carlos Fernandez Cordero, Mélanie Dalmasso, Emmanuel Compe, Corine Bertolotto, Eva Hernando, Irwin Davidson, Frédéric Coin
Publikováno v:
Cell Reports, Vol 42, Iss 11, Pp 113363- (2023)
Summary: Super-enhancers (SEs) are stretches of enhancers ensuring a high level of expression of key genes associated with cell function. The identification of cancer-specific SE-driven genes is a powerful means for the development of innovative ther
Externí odkaz:
https://doaj.org/article/58335d9b08f0478abe6c128c3b2392cd
Autor:
Yasmin Natalia Serina Secanechia, Isabelle Bergiers, Matt Rogon, Christian Arnold, Nicolas Descostes, Stephanie Le, Natalia López-Anguita, Kerstin Ganter, Chrysi Kapsali, Lea Bouilleau, Aaron Gut, Auguste Uzuotaite, Ayshan Aliyeva, Judith B. Zaugg, Christophe Lancrin
Publikováno v:
Scientific Reports, Vol 12, Iss 1, Pp 1-17 (2022)
Abstract Progress in the generation of Hematopoietic Stem and Progenitor Cells (HSPCs) in vitro and ex vivo has been built on the knowledge of developmental hematopoiesis, underscoring the importance of understanding this process. HSPCs emerge within
Externí odkaz:
https://doaj.org/article/3329f9ac9c47453dad74a525f1aa212e