Zobrazeno 1 - 10
of 11
pro vyhledávání: '"Stephanie L. Gu"'
Autor:
Stephanie L. Gu, Tara Maier, Andrea P. Moy, Stephen Dusza, David M. Faleck, Neil J. Shah, Mario E. Lacouture
Publikováno v:
Pharmaceuticals, Vol 16, Iss 11, p 1548 (2023)
Background: Immune-related cutaneous adverse events (ircAEs) are frequent and may reduce quality of life and consistent dosing. IL12/23 has been implicated in psoriasis, which is reminiscent of the psoriasiform/lichenoid ircAE phenotype. We report th
Externí odkaz:
https://doaj.org/article/369a6933d8b2478d9b794bf01af6cc99
Publikováno v:
Pharmaceuticals, Vol 16, Iss 11, p 1610 (2023)
Immune-related cutaneous adverse events (ircAEs) commonly occur in patients on treatment with immune checkpoint inhibitors and can significantly reduce patient quality of life. These are often treated with immunomodulatory agents, including glucocort
Externí odkaz:
https://doaj.org/article/6430a615323e40f1ae71d1d23942d393
Publikováno v:
Best Practice & Research Clinical Haematology. 36:101464
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::212f4e8f4b0ec25b4974b8f7b76acb53
https://doi.org/10.1016/j.beha.2023.101464
https://doi.org/10.1016/j.beha.2023.101464
Autor:
Ryan D. Mouery, Kimberly Lukasik, Carolyn Hsu, Thomas Bonacci, Derek L. Bolhuis, Xianxi Wang, C. Allie Mills, E. Drew Toomer, Owen G. Canterbury, Kevin C. Robertson, Timothy B. Branigan, Nicholas G. Brown, Laura E. Herring, Stephanie L. Gupton, Michael J. Emanuele
Publikováno v:
Cell Reports, Vol 43, Iss 8, Pp 114510- (2024)
Summary: Ubiquitination is an essential regulator of cell division. The kinase Polo-like kinase 1 (PLK1) promotes protein degradation at G2/M phase through the E3 ubiquitin ligase Skp1-Cul1-F box (SCF)βTrCP. However, the magnitude to which PLK1 shap
Externí odkaz:
https://doaj.org/article/43e0cb2829ad40e78a39e529e1e2c616
Autor:
Jianxiong Zeng, Yaoming Wang, Zhifei Luo, Lin-Chun Chang, Ji Seung Yoo, Huan Yan, Younho Choi, Xiaochun Xie, Benjamin E. Deverman, Viviana Gradinaru, Stephanie L. Gupton, Berislav V. Zlokovic, Zhen Zhao, Jae U. Jung
Publikováno v:
Cell Reports, Vol 42, Iss 8, Pp 113050- (2023)
Externí odkaz:
https://doaj.org/article/b0b6ef952c76495391af121d891e123f
Autor:
Fabio L. Urbina, Shalini Menon, Dennis Goldfarb, Reginald Edwards, M. Ben Major, Patrick Brennwald, Stephanie L. Gupton
Publikováno v:
Cell Reports, Vol 34, Iss 6, Pp 108743- (2021)
Summary: Neuronal morphogenesis involves dramatic plasma membrane expansion, fueled by soluble N-ethylmaleimide-sensitive factor attachment protein eceptors (SNARE)-mediated exocytosis. Distinct fusion modes described at synapses include full-vesicle
Externí odkaz:
https://doaj.org/article/2911a507b53746439eab7b9d27d46490
Autor:
Fabio L. Urbina, Stephanie L. Gupton
Publikováno v:
Frontiers in Molecular Neuroscience, Vol 13 (2020)
The formation of the nervous system involves establishing complex networks of synaptic connections between proper partners. This developmental undertaking requires the rapid expansion of the plasma membrane surface area as neurons grow and polarize,
Externí odkaz:
https://doaj.org/article/e0141d5c5f634783bafd706123940d86
Autor:
Jianxiong Zeng, Yaoming Wang, Zhifei Luo, Lin-Chun Chang, Ji Seung Yoo, Huan Yan, Younho Choi, Xiaochun Xie, Benjamin E. Deverman, Viviana Gradinaru, Stephanie L. Gupton, Berislav V. Zlokovic, Zhen Zhao, Jae U. Jung
Publikováno v:
Cell Reports, Vol 27, Iss 2, Pp 549-560.e6 (2019)
Summary: Excessive and unresolved neuroinflammation is a key component of the pathological cascade in brain injuries such as ischemic stroke. Here, we report that TRIM9, a brain-specific tripartite motif (TRIM) protein, was highly expressed in the pe
Externí odkaz:
https://doaj.org/article/64b0365a55b74fc5ad98ee407d18dd4a
Publikováno v:
International Journal of Molecular Sciences, Vol 22, Iss 10, p 5143 (2021)
How millions of axons navigate accurately toward synaptic targets during development is a long-standing question. Over decades, multiple studies have enriched our understanding of axonal pathfinding with discoveries of guidance molecules and morphoge
Externí odkaz:
https://doaj.org/article/3b5cf5be48bb44ceb77792b282d77e78
Publikováno v:
Viruses, Vol 13, Iss 2, p 153 (2021)
Mammalian orthoreovirus (reovirus), a dsRNA virus with a multilayered capsid, serves as a model system for studying the entry of similar viruses. The outermost layer of this capsid undergoes processing to generate a metastable intermediate. The metas
Externí odkaz:
https://doaj.org/article/00c320c88d2f4ff8a653ac79163973f5