Výsledky vyhledávání - "Stephanie L. Collins"

Akademický článek

Sphingosine Kinase 2 Regulates Aryl Hydrocarbon Receptor Nuclear Translocation and Target Gene Activation

Autor: Shigetoshi Yokoyama, Imhoi Koo, Daisuke Aibara, Yuan Tian, Iain A. Murray, Stephanie L. Collins, Denise M. Coslo, Mari Kono, Jeffrey M. Peters, Richard L. Proia, Frank J. Gonzalez, Gary H. Perdew, Andrew D. Patterson

Publikováno v: Advanced Science, Vol 11, Iss 40, Pp n/a-n/a (2024)

Abstract Sphingolipids play vital roles in metabolism and regulation. Previously, the aryl hydrocarbon receptor (AHR), a ligand‐activated transcription factor, was reported to directly regulate ceramide synthesis genes by binding to their promoters

Externí odkaz: https://doaj.org/article/a855de1025a445adaa26ec6581764497

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Akademický článek

The gut microbiome: an orchestrator of xenobiotic metabolism

Autor: Stephanie L. Collins, Andrew D. Patterson

Publikováno v: Acta Pharmaceutica Sinica B, Vol 10, Iss 1, Pp 19-32 (2020)

Microbes inhabiting the intestinal tract of humans represent a site for xenobiotic metabolism. The gut microbiome, the collection of microorganisms in the gastrointestinal tract, can alter the metabolic outcome of pharmaceuticals, environmental toxic

Externí odkaz: https://doaj.org/article/ff1c20b3b6304df88706176fec5add4f

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Bile acids and the gut microbiota: metabolic interactions and impacts on disease

Autor: Stephanie L. Collins, Jonathan G. Stine, Jordan E. Bisanz, C. Denise Okafor, Andrew D. Patterson

Publikováno v: Nature Reviews Microbiology. 21:236-247

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::3e124717a3ac0a81774c5c770314f015
https://doi.org/10.1038/s41579-022-00805-x

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Current Challenges and Recent Developments in Mass Spectrometry–Based Metabolomics

Autor: Andrew D. Patterson, Jeffrey M. Peters, Philip B. Smith, Stephanie L. Collins, Imhoi Koo

Publikováno v: Annual Review of Analytical Chemistry. 14:467-487

High-resolution mass spectrometry (MS) has advanced the study of metabolism in living systems by allowing many metabolites to be measured in a single experiment. Although improvements in mass detector sensitivity have facilitated the detection of gre

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::92aa8ced8191c934fd8ff16929257284
https://doi.org/10.1146/annurev-anchem-091620-015205

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Caloric restriction disrupts the microbiota and colonization resistance

Autor: Marie Friedrich, Sophia Dickmann, Jingwei Cai, Jordan E. Bisanz, Danielle Ingebrigtsen, Katherine S. Pollard, Steve Miller, Knut Mai, Svetlana Lyalina, Peter J. Turnbaugh, Stephanie L. Collins, Qi Yan Ang, Reiner Jumpertz von Schwartzenberg, Andrew D. Patterson, Joachim Spranger, Peter Spanogiannopoulos, Jessie A. Turnbaugh, Su Yang Liu

Publikováno v: Nature, vol 595, iss 7866
Nature

Diet is a major factor that shapes the gut microbiome1, but the consequences of diet-induced changes in the microbiome for host pathophysiology remain poorly understood. We conducted a randomized human intervention study using a very-low-calorie diet

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9951739cc715e52a3d1589bd43327abc
https://doi.org/10.1038/s41586-021-03663-4

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A Synthesis-Based Reverse Metabolomics Approach for the Discovery of Chemical Structures from Humans and Animals

Autor: Andrew D. Patterson, Stephanie L. Collins, Ramnik J. Xavier, Clary B. Clish, Robin Knight, Emily C. Gentry, Pieter C. Dorrestein, Erin S. Baker, Hera Vlamakis, Allegra T. Aron, Damian R. Plichta, Pedro Belda-Ferre, Alan K. Jarmusch, Morgan Panitchpakdi, Ashwin N. Ananthakrishnan, Dionicio Siegel, Mingxun Wang, Allison Stewart, Julian Avila-Pacheco

Identification of metabolites in humans remains challenging. Here, we present synthesis-based reverse metabolomics as a strategy for structure elucidation that aims to also find phenotypic associations. In this approach, MS/MS spectra are acquired fr

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::bcbaaa6a0e3d04d7941c46bddf991b70
https://doi.org/10.21203/rs.3.rs-820302/v1

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Improved methods for biomarker analysis of the big five mycotoxins enables reliable exposure characterization in a population of childbearing age women in Rwanda

Autor: Justin B. Renaud, J. David Miller, Amy McMillan, Jacob P. Walsh, Stephen Rulisa, Gregor Reid, Mark W. Sumarah, Stephanie L. Collins

Publikováno v: Microbiology & Immunology Publications

Of the five agriculturally important mycotoxins, AFB , FB , DON, ZEA and OTA, a well-characterized biomarker of exposure in blood is only available for aflatoxin. Working with a population of 139 women of childbearing age in Rwanda, we undertook a co

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::28ab2b0a32fae5a907b54dac0b037bfb
https://ir.lib.uwo.ca/mnipub/88

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Promising prebiotic candidate established by evaluation of lactitol, lactulose, raffinose, and oligofructose for maintenance of a Lactobacillus-dominated vaginal microbiota

Autor: Gregor Reid, Stephanie L. Collins, Mark W. Sumarah, Shannon Seney, Amy McMillan, Remco Kort, Charlotte van der Veer

Publikováno v: Applied and Environmental Microbiology, 84(5):e02200-17, 1-15. American Society for Microbiology
Collins, S L, McMillan, A, Seney, S, van der Veer, C, Kort, R, Sumarah, M W & Reid, G 2018, ' Promising prebiotic candidate established by evaluation of lactitol, lactulose, raffinose, and oligofructose for maintenance of a Lactobacillus-dominated vaginal microbiota ', Applied and Environmental Microbiology, vol. 84, no. 5, e02200-17, pp. 1-15 . https://doi.org/10.1128/AEM.02200-17
Microbiology & Immunology Publications
Applied and Environmental Microbiology
Applied and environmental microbiology, 84(5):e02200-17. American Society for Microbiology
Applied and Environmental Microbiology, 5, 84

Perturbations to the vaginal microbiota can lead to dysbiosis, including bacterial vaginosis (BV), which affects a large portion of the female population. In a healthy state, the vaginal microbiota is characterized by low diversity and colonization b

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2cbc522d215cfa9a89e49f9cdac0c491
https://research.vu.nl/en/publications/21929fc7-58a8-4fc6-8283-bb41ac83dc9c

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Microbiota-Mediated Modulation of Organophosphate Insecticide Toxicity by Species-Dependent Interactions with Lactobacilli in a Drosophila melanogaster Insect Model

Autor: Mark Trinder, Mark W. Sumarah, Brendan A. Daisley, Stephanie L. Collins, Tim McDowell, Gregor Reid

Publikováno v: Microbiology & Immunology Publications

Despite the benefits to the global food supply and agricultural economies, pesticides are believed to pose a threat to the health of both humans and wildlife. Chlorpyrifos (CP), a commonly used organophosphate insecticide, has poor target specificity

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::10ba8a16c0c5d115d28f0e25bd159976
https://pubmed.ncbi.nlm.nih.gov/29475860

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Distant Site Effects of Ingested Prebiotics

Autor: Stephanie L. Collins, Gregor Reid

Publikováno v: Nutrients
Microbiology & Immunology Publications
Nutrients, Vol 8, Iss 9, p 523 (2016)

The gut microbiome is being more widely recognized for its association with positive health outcomes, including those distant to the gastrointestinal system. This has given the ability to maintain and restore microbial homeostasis a new significance.

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d640bc1a217b62d2f1b1b0e44075ea72
http://europepmc.org/articles/PMC5037510

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