Zobrazeno 1 - 6
of 6
pro vyhledávání: '"Stephanie L. Born"'
Publikováno v:
Toxicological Sciences. 58:23-31
Coumarin, a natural product and fragrance ingredient, is a well recognized rat liver toxicant, and dietary administration at toxic dosages increased the incidence of rat cholangiocarcinomas and parenchymal liver-cell tumors in a chronic bioassay. Hep
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6bd4ebe23a8787e72361e19ffa3742dd
https://doi.org/10.1093/toxsci/58.1.23
https://doi.org/10.1093/toxsci/58.1.23
Publikováno v:
Toxicology and Applied Pharmacology. 151:45-56
Coumarin is a known hepatotoxicant in laboratory animals, particularly rats. However, the mouse lung was identified as a major target organ in a chronic bioassay, with an oral gavage dosage of 200 mg/kg coumarin increasing the incidence of alveolar/b
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::b1ca934a4b4b8188ab4350af5df72812
https://doi.org/10.1006/taap.1998.8442
https://doi.org/10.1006/taap.1998.8442
Autor:
Jeffrey D. Vassallo, Rhonda S. Kaetzel, Stephanie L. Born, Cindy L. Lewis, Donald J. Reed, Lois D. Lehman-McKeeman
Publikováno v:
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association. 48(6)
Coumarin was used as a model Clara cell toxicant to test the hypothesis that tolerance to injury requires increased γ-glutamyl transpeptidase (GGT) activity. Wildtype (GGT +/+ ) and GGT-deficient (GGT −/− ) mice on a C57BL/6/129SvEv hybrid backg
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::32df520b21bf6f6df888745d8bb14b09
https://pubmed.ncbi.nlm.nih.gov/20347914
https://pubmed.ncbi.nlm.nih.gov/20347914
Publikováno v:
Toxicological sciences : an official journal of the Society of Toxicology. 82(1)
Coumarin-induced mouse Clara cell toxicity is thought to result from the local formation of coumarin 3,4-epoxide (CE). However, this toxicity is not observed in the rat, indicating species differences in coumarin metabolism. The purpose of the presen
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7710a0f950e7f089c528f9e69d2846d6
https://pubmed.ncbi.nlm.nih.gov/15282406
https://pubmed.ncbi.nlm.nih.gov/15282406
Publikováno v:
Drug metabolism and disposition: the biological fate of chemicals. 30(5)
Coumarin, a widely used fragrance ingredient, is a rat liver and mouse lung toxicant. Species differences in toxicity are metabolism-dependent, with injury resulting from the cytochrome P450-mediated formation of coumarin 3,4-epoxide (CE). In this st
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::126db2bf00acb8f264db78c1ef12fb35
https://pubmed.ncbi.nlm.nih.gov/11950775
https://pubmed.ncbi.nlm.nih.gov/11950775
Publikováno v:
Toxicological sciences : an official journal of the Society of Toxicology. 51(2)
Coumarin was identified as a mouse-lung carcinogen following oral gavage administration in a chronic bioassay, and was shown to cause the selective necrosis of terminal bronchiolar Clara (non-ciliated bronchiolar epithelial) cells in the mouse lung a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4fd97acbf922c2f3f71af41b0679b3db
https://pubmed.ncbi.nlm.nih.gov/10543032
https://pubmed.ncbi.nlm.nih.gov/10543032