From genomes to vaccines via the proteome

Autor: R Alan Wilson, Rachel S Curwen, Simon Braschi, Stephanie L Hall, Patricia S Coulson, Peter D Ashton

Publikováno v: Memorias do Instituto Oswaldo Cruz, Vol 99, Pp 45-50 (2004)

An effective vaccine against schistosomiasis mansoni would be a valuable control tool and the high levels of protection elicited in rodents and primates by radiation-attenuated cercariae provide proof of principle. A major obstacle to vaccine develop

Externí odkaz: https://doaj.org/article/1c2676a18f764bffaaa645cc49efdd80

Elimination of Schistosoma mansoni Adult Worms by Rhesus Macaques: Basis for a Therapeutic Vaccine?

Autor: R Alan Wilson, Jan A M Langermans, Govert J van Dam, Richard A Vervenne, Stephanie L Hall, William C Borges, Gary P Dillon, Alan W Thomas, Patricia S Coulson

Publikováno v: PLoS Neglected Tropical Diseases, Vol 2, Iss 9, p e290 (2008)

Among animal models of schistosomiasis, the rhesus macaque is unique in that an infection establishes but egg excretion rapidly diminishes, potentially due to loss of adult worms from the portal system via shunts or death by immune attack.To investig

Externí odkaz: https://doaj.org/article/d7913f0ecefd4975a8815778e6f35dd8

Insights into blood feeding by schistosomes from a proteomic analysis of worm vomitus

Autor: Stephanie L. Hall, Italo M. Cesari, R. Alan Wilson, Simon Braschi, Martha Truscott, William Mathieson

Publikováno v: Molecular and biochemical parasitology. 179(1)

Whilst the schistosome tegument has been intensively studied there is little information about processes in the gut, the other major interface with the bloodstream, apart from the well characterised cascade of proteases involved in haemoglobin digest

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ae169e054a502634d8d2b437aac9c5f3
https://pubmed.ncbi.nlm.nih.gov/21605600

From genomes to vaccines via the proteome

Autor: Stephanie L. Hall, Simon Braschi, R. Alan Wilson, Rachel S. Curwen, Patricia S. Coulson, Peter D. Ashton

Publikováno v: Memórias do Instituto Oswaldo Cruz, Volume: 99 Supplement 1, Pages: 45-50, Published: AUG 2004
Memórias do Instituto Oswaldo Cruz., Vol 99, Pp 45-50 (2004)

An effective vaccine against schistosomiasis mansoni would be a valuable control tool and the high levels of protection elicited in rodents and primates by radiation-attenuated cercariae provide proof of principle. A major obstacle to vaccine develop

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::13d7f69a38aed1586d7a767a161f116b
http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0074-02762004000900008&lng=en&tlng=en

Elimination of Schistosoma mansoni Adult Worms by Rhesus Macaques: Basis for a Therapeutic Vaccine?

Autor: Stephanie L. Hall, William de Castro Borges, Jan A.M. Langermans, Govert J. van Dam, Gary P. Dillon, Patricia S. Coulson, R. Alan Wilson, Alan W. Thomas, Richard A. W. Vervenne

Publikováno v: Repositório Institucional da UFOP
Universidade Federal de Ouro Preto (UFOP)
instacron:UFOP
PLoS Neglected Tropical Diseases
PLoS Neglected Tropical Diseases, Vol 2, Iss 9, p e290 (2008)

Background Among animal models of schistosomiasis, the rhesus macaque is unique in that an infection establishes but egg excretion rapidly diminishes, potentially due to loss of adult worms from the portal system via shunts or death by immune attack.

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2348f8414eba50ea926876b8d87a9a42
https://doi.org/10.1371/journal.pntd.0000290