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Autor:
Stephanie L Gibson, Gordon L Carlson, P. Davies, Zubida M. Al-Majdoub, Matthew D Harwood, Brahim Achour, Geoffrey Warhurst, Jill Barber, Amin Rostami-Hodjegan, Narciso Couto
Publikováno v:
Drug Metabolism and Disposition
Drug Metab Dispos
Drug Metab Dispos
The levels of drug-metabolizing enzymes (DMEs) and transporter proteins in the human intestine are pertinent to determine oral drug bioavailability. Despite the paucity of reports on such measurements, it is well recognized that these values are esse