Zobrazeno 1 - 9
of 9
pro vyhledávání: '"Stephanie L Baringer"'
Autor:
Stephanie L. Baringer, Kondaiah Palsa, Vladimir S. Spiegelman, Ian A. Simpson, James R. Connor
Publikováno v:
Journal of Biomedical Science, Vol 30, Iss 1, Pp 1-13 (2023)
Abstract Background Apo- (iron free) and holo- (iron bound) transferrin (Tf) participate in precise regulation of brain iron uptake at endothelial cells of the blood–brain barrier. Apo-Tf indicates an iron-deficient environment and stimulates iron
Externí odkaz:
https://doaj.org/article/b95d22665c3c4e128ec7e5ea69f71b76
Publikováno v:
Fluids and Barriers of the CNS, Vol 19, Iss 1, Pp 1-10 (2022)
Abstract Background The brain requires iron for a number of processes, including energy production. Inadequate or excessive amounts of iron can be detrimental and lead to a number of neurological disorders. As such, regulation of brain iron uptake is
Externí odkaz:
https://doaj.org/article/f0ff6eb5fcb84770986126f54fddb6a5
Publikováno v:
Journal of Neurochemistry. 165:625-642
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::fd606ac0524cb73043ef85f0a54e4aaf
https://doi.org/10.1111/jnc.15819
https://doi.org/10.1111/jnc.15819
Autor:
Stephanie L. Baringer, Avraham S. Lukacher, Kondaiah Palsa, Hyosung Kim, Ethan S. Lippmann, Vladimir S. Spiegelman, Ian A. Simpson, James R. Connor
Publikováno v:
bioRxiv
Excessive brain iron accumulation is observed in early in the onset of Alzheimer’s disease, notably prior to widespread proteinopathy. These findings suggest that increases in brain iron levels are due to a dysregulation of the iron transport mecha
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1e4da8b9b2d6106d7b6d0a6b444ee3fb
https://europepmc.org/articles/PMC10245582/
https://europepmc.org/articles/PMC10245582/
Publikováno v:
bioRxiv
BackgroundApo- (iron free) and holo- (iron bound) transferrin (Tf) participate in precise regulation of brain iron uptake at endothelial cells of the blood-brain barrier. Apo-Tf indicates an iron deficient environment and stimulates iron release, whi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cab5471a634abfd40179abcb344c8287
https://doi.org/10.21203/rs.3.rs-2429356/v1
https://doi.org/10.21203/rs.3.rs-2429356/v1
Autor:
Kondaiah Palsa, Stephanie L. Baringer, Ganesh Shenoy, Vladimir S. Spiegelman, Ian A. Simpson, James R. Connor
Publikováno v:
Journal of Biological Chemistry. 299:102868
Iron is essential for normal brain development and function. Hence, understanding the mechanisms of iron efflux at the blood-brain barrier and their regulation are critical for the establishment of brain iron homeostasis. Here, we have investigated t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::116ffc1c0ca5349124698a99e4ccce7a
https://doi.org/10.1016/j.jbc.2022.102868
https://doi.org/10.1016/j.jbc.2022.102868
Publikováno v:
Journal of Alzheimer's Disease. 72:1323-1339
Alzheimer’s disease (AD) has several hallmark features including amyloid-β plaque deposits and neuronal loss. Here, we characterized amyloid-β plaque aggregation and parvalbumin-positive (PV) GABAergic neurons in 6 – 9 month old 5xFAD mice harb
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9934493f1830a0b84844c2a949a25a73
https://doi.org/10.3233/jad-181190
https://doi.org/10.3233/jad-181190
Autor:
Stephanie L. Baringer, Deborah L. Croteau, Beverly A. Baptiste, Tomasz Kulikowicz, Robert M. Brosh, Vilhelm A. Bohr, Joshua A. Sommers
Publikováno v:
DNA Repair (Amst)
DNA polymerase beta (POLβ), well known for its role in nuclear DNA base excision repair (BER), has been shown to be present in the mitochondria of several different cell types. Here we present a side-by-side comparison of BER activities of POLβ and
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::aa1cbbeb4d3ae7cf5c2a3c7545bbdb78
https://pubmed.ncbi.nlm.nih.gov/33540226
https://pubmed.ncbi.nlm.nih.gov/33540226
Autor:
Stephanie L. Baringer, Beimeng Yang, Mansi Babbar, Yujun Hou, Vilhelm A. Bohr, Deborah L. Croteau, David M. Figueroa
Publikováno v:
Free Radic Biol Med
Cellular exposure to ionizing radiation leads to oxidatively generated DNA damage, which has been implicated in neurodegenerative diseases. DNA damage is repaired by the evolutionarily conserved base excision repair (BER) system. Exposure of mice to
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::58ea80dbce19e0d1d86cb53a86a063d9
https://pubmed.ncbi.nlm.nih.gov/31175982
https://pubmed.ncbi.nlm.nih.gov/31175982