Zobrazeno 1 - 10
of 12
pro vyhledávání: '"Stephanie L, Celano"'
Autor:
Robert M. Vaughan, Jennifer J. Kordich, Chun-Yuan Chan, Nanda K. Sasi, Stephanie L. Celano, Kellie A. Sisson, Megan Van Baren, Matthew G. Kortus, Dean J. Aguiar, Katie R. Martin, Jeffrey P. MacKeigan
Publikováno v:
Frontiers in Oncology, Vol 12 (2022)
The tuberous sclerosis complex (TSC) is a rare genetic syndrome and multisystem disease resulting in tumor formation in major organs. A molecular hallmark of TSC is a dysregulation of the mammalian target of rapamycin (mTOR) through loss-of-function
Externí odkaz:
https://doaj.org/article/6b788d8dffba41d183d8e4244c25e1f9
Autor:
Stephanie L. Celano, Lisette P. Yco, Matthew G. Kortus, Abigail R. Solitro, Hakan Gunaydin, Mark Scott, Edward Spooner, Ronan C. O'Hagan, Peter Fuller, Katie R. Martin, Stuart D. Shumway, Jeffrey P. MacKeigan
Publikováno v:
iScience, Vol 15, Iss , Pp 109-118 (2019)
Summary: In cancer, autophagy is upregulated to promote cell survival and tumor growth during times of nutrient stress and can confer resistance to drug treatments. Several major signaling networks control autophagy induction, including the p53 tumor
Externí odkaz:
https://doaj.org/article/1963b7c4000c4a54a648f6f246f51215
Autor:
Katie R. Martin, Stephanie L. Celano, Abigail R. Solitro, Hakan Gunaydin, Mark Scott, Ronan C. O'Hagan, Stuart D. Shumway, Peter Fuller, Jeffrey P. MacKeigan
Publikováno v:
iScience, Vol 8, Iss , Pp 74-84 (2018)
Summary: In response to stress, cancer cells generate nutrients and energy through a cellular recycling process called autophagy, which can promote survival and tumor progression. Accordingly, autophagy inhibition has emerged as a potential cancer tr
Externí odkaz:
https://doaj.org/article/da31c51b36c548718b2b7aeb41c96998
Autor:
Duc Quach, Timothy J. Collier, Andreas Weihofen, Holly Kordasiewicz, Melissa Berman, Esteban Luna, Hien T Zhao, Apoorva Mohan, Ivette M. Sandoval, Stephanie L. Celano, Alix Booms, Brian F. Daley, Emily Schulz, Tracy Cole, Luke Jandreski, Kathy Steece-Collier, Katrina L. Paumier, Kelvin C. Luk, Danielle Graham, Jack W. Lipton, C. Frank Bennett, Allyson Cole-Strauss, Caryl E. Sortwell, Mackenzie Welch, Eric E. Swayze
Publikováno v:
JCI Insight
JCI Insight, Vol 6, Iss 5 (2021)
JCI Insight, Vol 6, Iss 5 (2021)
Parkinson’s disease (PD) is a prevalent neurodegenerative disease with no approved disease-modifying therapies. Multiplications, mutations, and single nucleotide polymorphisms in the SNCA gene, encoding α-synuclein (aSyn) protein, either cause or
Autor:
Ronan C. O'Hagan, Abigail R. Solitro, Mark E. Scott, Jeffrey P. MacKeigan, Stuart D. Shumway, Hakan Gunaydin, Katie R. Martin, Peter Fuller, Stephanie L. Celano
Publikováno v:
iScience
iScience, Vol 8, Iss, Pp 74-84 (2018)
iScience, Vol 8, Iss, Pp 74-84 (2018)
Summary In response to stress, cancer cells generate nutrients and energy through a cellular recycling process called autophagy, which can promote survival and tumor progression. Accordingly, autophagy inhibition has emerged as a potential cancer tre
Autor:
Tracy Cole, Duc Quach, C. Frank Bennett, Stephanie L. Celano, Emily Schulz, Luke Jandreski, Melissa Berman, Caryl E. Sortwell, Holly B. Kordasiewicz, Andreas Weihofen, Alix Booms, Timothy J. Collier, Mackenzie Welch, Allyson Cole-Strauss, Eric E. Swayze, Kelvin C. Luk, Apoorva Mohan, Katrina L. Paumier, Danielle Graham, Jack W. Lipton, Kathy Steece-Collier, Esteban Luna, Ivette M. Sandoval, Hien T Zhao, Brian F. Daley
Parkinson’s disease (PD) is a prevalent neurodegenerative disease with no approved disease-modifying therapies. Multiplications, mutations, and single nucleotide polymorphisms in the SNCA gene, encoding alpha-synuclein protein (aSyn), either cause
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1dca9a4dde9665efc7437571a0a7b9ce
Autor:
Mark E. Scott, Matthew G. Kortus, Edward Spooner, Ronan C. O'Hagan, Lisette P. Yco, Peter Fuller, Katie R. Martin, Stephanie L. Celano, Jeffrey P. MacKeigan, Stuart D. Shumway, Abigail R. Solitro, Hakan Gunaydin
Publikováno v:
iScience
iScience, Vol 15, Iss, Pp 109-118 (2019)
iScience, Vol 15, Iss, Pp 109-118 (2019)
Summary In cancer, autophagy is upregulated to promote cell survival and tumor growth during times of nutrient stress and can confer resistance to drug treatments. Several major signaling networks control autophagy induction, including the p53 tumor
Publikováno v:
Methods in molecular biology (Clifton, N.J.). 1862
Tumorigenesis relies on the ability of cancer cells to obtain necessary nutrients and fulfill increased energy demands associated with rapid proliferation. However, as a result of increased metabolite consumption and poor vascularization, most cancer
Publikováno v:
Metabolic Signaling ISBN: 9781493987689
Tumorigenesis relies on the ability of cancer cells to obtain necessary nutrients and fulfill increased energy demands associated with rapid proliferation. However, as a result of increased metabolite consumption and poor vascularization, most cancer
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::3c763620fda0924ff8584bd12c9b3623
https://doi.org/10.1007/978-1-4939-8769-6_11
https://doi.org/10.1007/978-1-4939-8769-6_11
Autor:
Nicole K. Polinski, Ivette M. Sandoval, John Q. Trojanowski, Fredric P. Manfredsson, Emily Schulz, Jack W. Lipton, Kathy Steece-Collier, Christopher J. Kemp, Caryl E. Sortwell, Katrina L. Paumier, Virginia M.-Y. Lee, Timothy J. Collier, Sheila M. Fleming, Stephanie L. Celano, Nicholas M. Kanaan, Kelvin C. Luk, Elliott W. Dirr
Publikováno v:
Neurobiology of Disease, Vol 82, Iss, Pp 185-199 (2015)
Previous studies demonstrate that intrastriatal injections of fibrillar alpha-synuclein (α-syn) into mice induce Parkinson's disease (PD)-like Lewy body (LB) pathology formed by aggregated α-syn in anatomically interconnected regions and significan