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Autor:
Mark Smith, Atsuko Ochida, Stephanie Kabeche, Thamina Akther, Takashi Ichikawa, Michael J. Pulkoski-Gross, Jumpei Aida, Paul S. Humphries, Ellen Yeh
Publikováno v:
Bioorganicmedicinal chemistry letters. 41
A series of novel thiazole-containing amides were synthesized. A structure-activity relationship study of these compounds led to the identification of potent and selective PfFPPS/GGPPS inhibitors with good in vitro ADME profiles. The most promising c