Zobrazeno 1 - 10
of 64
pro vyhledávání: '"Stephanie K. Seidlits"'
Autor:
Alireza Sohrabi, Stephanie K. Seidlits
Publikováno v:
STAR Protocols, Vol 5, Iss 3, Pp 103266- (2024)
Summary: Glioblastoma (GBM) is the most common and lethal type of primary brain tumor. Physiologically, GBM cells experience a heterogeneous mechanical landscape. Here, we present an in vitro method to study the effects of tissue stiffness on patient
Externí odkaz:
https://doaj.org/article/6e459382494b4606a01607234a724d82
Autor:
Usha Nekanti, Pooja S. Sakthivel, Atena Zahedi, Dana A. Creasman, Rebecca A. Nishi, Courtney M. Dumont, Katja M. Piltti, Glenn L. Guardamondo, Norbert Hernandez, Xingyuan Chen, Hui Song, Xiaoxiao Lin, Joshua Martinez, Lillian On, Anita Lakatos, Kiran Pawar, Brian T. David, Zhiling Guo, Stephanie K. Seidlits, Xiangmin Xu, Lonnie D. Shea, Brian J. Cummings, Aileen J. Anderson
Publikováno v:
npj Regenerative Medicine, Vol 9, Iss 1, Pp 1-20 (2024)
Abstract Regeneration in the injured spinal cord is limited by physical and chemical barriers. Acute implantation of a multichannel poly(lactide-co-glycolide) (PLG) bridge mechanically stabilizes the injury, modulates inflammation, and provides a per
Externí odkaz:
https://doaj.org/article/a83ff1b397fa4089b91e5e42b4e4bde0
Autor:
Alireza Sohrabi, Austin E.Y.T. Lefebvre, Mollie J. Harrison, Michael C. Condro, Talia M. Sanazzaro, Gevick Safarians, Itay Solomon, Soniya Bastola, Shadi Kordbacheh, Nadia Toh, Harley I. Kornblum, Michelle A. Digman, Stephanie K. Seidlits
Publikováno v:
Cell Reports, Vol 42, Iss 10, Pp 113175- (2023)
Summary: The mechanical properties of solid tumors influence tumor cell phenotype and the ability to invade surrounding tissues. Using bioengineered scaffolds to provide a matrix microenvironment for patient-derived glioblastoma (GBM) spheroids, this
Externí odkaz:
https://doaj.org/article/d2250eca7fe7426383653643a3dc60db
Autor:
Weikun Xiao, Mahsa Pahlavanneshan, Chae-Young Eun, Xinyu Zhang, Charlene DeKalb, Bayan Mahgoub, Hanaa Knaneh-Monem, Sana Shah, Alireza Sohrabi, Stephanie K. Seidlits, Reginald Hill
Publikováno v:
Matrix Biology Plus, Vol 14, Iss , Pp 100111- (2022)
In pancreatic ductal adenocarcinoma (PDAC), the abundant stromal cells which comprise the tumor microenvironment constitute more than 90% of the primary tumor bulk. Moreover, this desmoplastic environment has been found to be three times stiffer than
Externí odkaz:
https://doaj.org/article/a8af28f560704a41b9f8baf5d777701c
Autor:
Zin Z. Khaing, Jessica Y. Chen, Gevick Safarians, Sohib Ezubeik, Nicolas Pedroncelli, Rebecca D. Duquette, Tobias Prasse, Stephanie K. Seidlits
Publikováno v:
International Journal of Molecular Sciences, Vol 24, Iss 4, p 3824 (2023)
Spinal cord injury (SCI) often causes loss of sensory and motor function resulting in a significant reduction in quality of life for patients. Currently, no therapies are available that can repair spinal cord tissue. After the primary SCI, an acute i
Externí odkaz:
https://doaj.org/article/3f7903c57fb84f098ef87f0118bc3e80
Publikováno v:
Frontiers in Cell and Developmental Biology, Vol 9 (2021)
Chemotherapy resistance to glioblastoma (GBM) remains an obstacle that is difficult to overcome, leading to poor prognosis of GBM patients. Many previous studies have focused on resistance mechanisms intrinsic to cancer cells; the microenvironment su
Externí odkaz:
https://doaj.org/article/8b6b28fc8b234a5db07106fd0017d6ad
Autor:
Arshia Ehsanipour, Mayilone Sathialingam, Laila M. Rad, Joseph de Rutte, Rebecca D. Bierman, Jesse Liang, Weikun Xiao, Dino Di Carlo, Stephanie K. Seidlits
Publikováno v:
APL Bioengineering, Vol 5, Iss 1, Pp 016104-016104-18 (2021)
Biomaterials are being developed as therapeutics for spinal cord injury (SCI) that can stabilize and bridge acute lesions and mediate the delivery of transgenes, providing a localized and sustained reservoir of regenerative factors. For clinical use,
Externí odkaz:
https://doaj.org/article/22347fddcd3e4649b5ee54ed2b0248bc
Publikováno v:
Biomarker Insights, Vol 2015, Iss Suppl. 1, Pp 11-29 (2015)
Externí odkaz:
https://doaj.org/article/e48bad1ae0f5476199e417e25afcc249
Publikováno v:
The Scientific World Journal, Vol 3, Pp 881-902 (2003)
Although numerous studies have investigated the relationship between saccadic eye movements and spatial attention, one fundamental issue remains controversial. Some studies have suggested that spatial attention facilitates saccades, whereas others ha
Externí odkaz:
https://doaj.org/article/a9b53d389ea54aff9b6490a32841da1b
Autor:
Gevick Safarians, Alireza Sohrabi, Itay Solomon, Weikun Xiao, Soniya Bastola, Bushra W. Rajput, Mary Epperson, Isabella Rosenzweig, Kelly Tamura, Breahna Singer, Joyce Huang, Mollie J. Harrison, Talia Sanazzaro, Michael C. Condro, Harley I. Kornblum, Stephanie K. Seidlits
Publikováno v:
Advanced healthcare materials, vol 12, iss 14
Adv Healthc Mater
Adv Healthc Mater
Increased secretion of hyaluronic acid (HA), a glycosaminoglycan abundant in the brain extracellular matrix (ECM), correlates with worse clinical outcomes for glioblastoma (GBM) patients. GBM cells aggressively invade the brain parenchyma while encou
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dd1f1ffa133db5e6799a899e5488e924
https://escholarship.org/uc/item/4884w8bj
https://escholarship.org/uc/item/4884w8bj