Zobrazeno 1 - 10
of 23
pro vyhledávání: '"Stephanie J. Child"'
Publikováno v:
Pathogens, Vol 11, Iss 7, p 790 (2022)
Decades of research on vaccinia virus (VACV) have provided a wealth of insights and tools that have proven to be invaluable in a broad range of studies of molecular virology and pathogenesis. Among the challenges that viruses face are intrinsic host
Externí odkaz:
https://doaj.org/article/7a2bbf261780435e9544bed3f5911569
Publikováno v:
PLoS Pathogens, Vol 17, Iss 1, p e1009088 (2021)
Cytomegaloviruses (CMVs) are generally unable to cross species barriers, in part because prolonged coevolution with one host species limits their ability to evade restriction factors in other species. However, the limitation in host range is incomple
Externí odkaz:
https://doaj.org/article/10dab8affdc84303a71b630eaae0e918
Publikováno v:
bioRxiv
Myxovirus resistance proteins (MxA and MxB) are interferon-induced proteins that exert antiviral activity against a diverse range of RNA and DNA viruses. In primates, MxA has been shown to inhibit myxoviruses, bunyaviruses, and hepatitis B virus, whe
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8b7046aea4bc523be31e7d9f269de542
https://europepmc.org/articles/PMC10312577/
https://europepmc.org/articles/PMC10312577/
Publikováno v:
PLoS Pathogens, Vol 17, Iss 1, p e1009088 (2021)
PLoS Pathogens
PLoS Pathogens
Cytomegaloviruses (CMVs) are generally unable to cross species barriers, in part because prolonged coevolution with one host species limits their ability to evade restriction factors in other species. However, the limitation in host range is incomple
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::63b0a32722cd732e73ac3aa371b4319b
https://doi.org/10.1371/journal.ppat.1009088
https://doi.org/10.1371/journal.ppat.1009088
Autor:
Stephanie J. Child, Elizabeth E. Gray, Adam P. Geballe, Damion Winship, Jessica M. Snyder, Daniel B. Stetson
Publikováno v:
Immunity. 45:255-266
Detection of intracellular DNA triggers activation of the STING-dependent interferon-stimulatory DNA (ISD) pathway, which is essential for antiviral responses. Multiple DNA sensors have been proposed to activate this pathway, including AIM2-like rece
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ad64b66714ad4109874e78e0fe480c0a
https://doi.org/10.1016/j.immuni.2016.06.015
https://doi.org/10.1016/j.immuni.2016.06.015
Publikováno v:
Virology. 489:75-85
Human cytomegalovirus (HCMV) lacking TRS1 and IRS1 (HCMV[ΔI/ΔT]) cannot replicate in cell culture. Although both proteins can block the protein kinase R (PKR) pathway, they have multiple other activities and binding partners. It remains unknown whi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5b472e959d7a2f996606db7d971fcaf8
https://doi.org/10.1016/j.virol.2015.11.032
https://doi.org/10.1016/j.virol.2015.11.032
Autor:
Avraham Bayer, Daniel Malouli, Adam P. Geballe, Sarah E. Hickson, Klaus Früh, Stephanie J. Child
Publikováno v:
Journal of virology. 92(6)
While cytomegalovirus (CMV) infections are often limited in host range by lengthy coevolution with a single host species, a few CMVs are known to deviate from this rule. For example, rhesus macaque CMV (RhCMV), a model for human CMV (HCMV) pathogenes
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f868fa194056d28f4b994836dc7ec300
https://pubmed.ncbi.nlm.nih.gov/29263260
https://pubmed.ncbi.nlm.nih.gov/29263260
Publikováno v:
PLoS Pathogens
PLoS Pathogens, Vol 12, Iss 10, p e1005966 (2016)
PLoS Pathogens, Vol 12, Iss 10, p e1005966 (2016)
During millions of years of coevolution with their hosts, cytomegaloviruses (CMVs) have succeeded in adapting to overcome host-specific immune defenses, including the protein kinase R (PKR) pathway. Consequently, these adaptations may also contribute
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::19e103dbe1d0b4a98e8e0df374bea8fd
http://europepmc.org/articles/PMC5079575
http://europepmc.org/articles/PMC5079575
Autor:
Kelsey S. Rogers, Jacob O. Kitzman, Stephanie J. Child, Michael T. Eickbush, Harmit S. Malik, Adam P. Geballe, Nels C. Elde, Jay Shendure
Publikováno v:
Cell. 150:831-841
SummaryIn contrast to RNA viruses, double-stranded DNA viruses have low mutation rates yet must still adapt rapidly in response to changing host defenses. To determine mechanisms of adaptation, we subjected the model poxvirus vaccinia to serial propa
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3b5d2d9f85dc4a642aa3c2294c457e3b
https://doi.org/10.1016/j.cell.2012.05.049
https://doi.org/10.1016/j.cell.2012.05.049
Autor:
Adam P. Geballe, Stephanie J. Child
Publikováno v:
Journal of Virology. 83:1790-1799
Many viruses have evolved mechanisms to evade the repression of translation mediated by protein kinase R (PKR). In the case of murine cytomegalovirus (MCMV), the protein products of two essential genes, m142 and m143, bind to double-stranded RNA (dsR
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5312e1cf15d44e4bc73f2f09b887d9c9
https://doi.org/10.1128/jvi.01484-08
https://doi.org/10.1128/jvi.01484-08