Zobrazeno 1 - 10
of 99
pro vyhledávání: '"Stephanie J Bissel"'
Publikováno v:
Acta Neuropathologica Communications, Vol 12, Iss 1, Pp 1-18 (2024)
Abstract Aging is the greatest known risk factor for most neurodegenerative diseases. Myelin degeneration is an early pathological indicator of these diseases and a normal part of aging; albeit, to a lesser extent. Despite this, little is known about
Externí odkaz:
https://doaj.org/article/f24b75a126de4fa59dfa6349d0e01838
Autor:
Miguel Moutinho, Israel Coronel, Andy P. Tsai, Gonzalo Viana Di Prisco, Taylor Pennington, Brady K. Atwood, Shweta S. Puntambekar, Daniel C. Smith, Pablo Martinez, Seonggyun Han, Younghee Lee, Cristian A. Lasagna-Reeves, Bruce T. Lamb, Stephanie J. Bissel, Kwangsik Nho, Gary E. Landreth
Publikováno v:
Genome Medicine, Vol 15, Iss 1, Pp 1-16 (2023)
Abstract Background TREM2 is a transmembrane receptor expressed by myeloid cells and acts to regulate their immune response. TREM2 governs the response of microglia to amyloid and tau pathologies in the Alzheimer’s disease (AD) brain. TREM2 is also
Externí odkaz:
https://doaj.org/article/117dd81f7fed426b87efb3f7e4a4b1d0
Autor:
Andy P. Tsai, Chuanpeng Dong, Peter Bor-Chian Lin, Evan J. Messenger, Brad T. Casali, Miguel Moutinho, Yunlong Liu, Adrian L. Oblak, Bruce T. Lamb, Gary E. Landreth, Stephanie J. Bissel, Kwangsik Nho
Publikováno v:
Genome Medicine, Vol 14, Iss 1, Pp 1-13 (2022)
Abstract Background Alzheimer’s disease (AD) is characterized by robust microgliosis and phenotypic changes that accompany disease pathogenesis. Accumulating evidence from genetic studies suggests the importance of phospholipase C γ 2 (PLCG2) in l
Externí odkaz:
https://doaj.org/article/214bb87193a04e81a5564cbf54f44674
Autor:
Jacqueline Corry, Gwenddolen Kettenburg, Amit A Upadhyay, Megan Wallace, Michelle M Marti, Elizabeth R Wonderlich, Stephanie J Bissel, Kyndal Goss, Timothy J Sturgeon, Simon C Watkins, Douglas S Reed, Steven E Bosinger, Simon M Barratt-Boyes
Publikováno v:
PLoS Pathogens, Vol 18, Iss 3, p e1010395 (2022)
Severe influenza kills tens of thousands of individuals each year, yet the mechanisms driving lethality in humans are poorly understood. Here we used a unique translational model of lethal H5N1 influenza in cynomolgus macaques that utilizes inhalatio
Externí odkaz:
https://doaj.org/article/158a2ae8d6714870a76bb7c76eda7ece
Autor:
Vaishnavi S. Jadhav, Peter B. C. Lin, Taylor Pennington, Gonzalo Viana Di Prisco, Asha Jacob Jannu, Guixiang Xu, Miguel Moutinho, Jie Zhang, Brady K. Atwood, Shweta S. Puntambekar, Stephanie J. Bissel, Adrian L. Oblak, Gary E. Landreth, Bruce T. Lamb
Publikováno v:
Molecular Neurodegeneration, Vol 15, Iss 1, Pp 1-16 (2020)
Abstract Background Triggering receptor expressed on myeloid cells 2 (TREM2) is expressed in the brain exclusively on microglia and genetic variants are linked to neurodegenerative diseases including Alzheimer’s disease (AD), frontotemporal dementi
Externí odkaz:
https://doaj.org/article/5b13dac21794463aaf99674ad8572591
Autor:
Stephanie J. Bissel, Kate Gurnsey, Hank P. Jedema, Nicholas F. Smith, Guoji Wang, Charles W. Bradberry, Clayton A. Wiley
Publikováno v:
Retrovirology, Vol 15, Iss 1, Pp 1-19 (2018)
Abstract Background Damage to the central nervous system during HIV infection can lead to variable neurobehavioral dysfunction termed HIV-associated neurocognitive disorders (HAND). There is no clear consensus regarding the neuropathological or cellu
Externí odkaz:
https://doaj.org/article/28f5436df2404d98bf9cb09fb6df4a01
Autor:
Dominic J. Acri, Yanwen You, Mason D. Tate, Brianne McCord, A. Daniel Sharify, Sutha John, Hande Karahan, Byungwook Kim, Luke C. Dabin, Stéphanie Philtjens, H.R. Sagara Wijeratne, Tyler J. McCray, Daniel C. Smith, Stephanie J. Bissel, Bruce T. Lamb, Cristian A. Lasagna-Reeves, Jungsu Kim
Publikováno v:
bioRxiv
Mouse genetic backgrounds have been shown to modulate amyloid accumulation and propagation of tau aggregates. Previous research into these effects has highlighted the importance of studying the impact of genetic heterogeneity on modeling Alzheimer’
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5bf8a37fbc132fdf0499fb25987e701b
https://doi.org/10.1101/2023.01.28.526029
https://doi.org/10.1101/2023.01.28.526029
Publikováno v:
Proceedings of IMPRS. 5
Objective/Hypothesis: The apoliprotein E epsilon 4 (APOE4) variant is the strongest genetic risk factor for late-onset Alzheimer’s disease (AD) and is associated with accelerated clinical disease. Increasing evidence suggests that the immune system
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::8bf07b81b6100affd15b7730564a37c8
https://doi.org/10.18060/26899
https://doi.org/10.18060/26899
Autor:
Andy P. Tsai, Chuanpeng Dong, Peter Bor-Chian Lin, Adrian L. Oblak, Gonzalo Viana Di Prisco, Nian Wang, Nicole Hajicek, Adam J. Carr, Emma K. Lendy, Oliver Hahn, Micaiah Atkins, Aulden G. Foltz, Jheel Patel, Guixiang Xu, Miguel Moutinho, John Sondek, Qisheng Zhang, Andrew D. Mesecar, Yunlong Liu, Brady K. Atwood, Tony Wyss-Coray, Kwangsik Nho, Stephanie J. Bissel, Bruce T. Lamb, Gary E. Landreth
SummaryGenetic association studies have demonstrated the critical involvement of the microglial immune response in Alzheimer’s disease (AD) pathogenesis. Phospholipase C-gamma-2 (PLCG2) is selectively expressed by microglia and acts in many immune
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::c3895356082b46512c40208d166c14e0
https://doi.org/10.1101/2022.12.08.519685
https://doi.org/10.1101/2022.12.08.519685
Autor:
Andy Po‐Yi Tsai, Peter Bor‐Chian Lin, Chuanpeng Dong, Gonzalo Viana Di Prisco, Nian Wang, Stephanie J Bissel, Adrian L Oblak, Miguel Moutinho, Yunlong Liu, Brady Atwood, Kwangsik Nho, Bruce T Lamb, Gary E Landreth
Publikováno v:
Alzheimer's & Dementia. 18
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::a2743419e8c717daca9206deba7d0342
https://doi.org/10.1002/alz.066966
https://doi.org/10.1002/alz.066966