Zobrazeno 1 - 10
of 19
pro vyhledávání: '"Stephanie J Alexopoulos"'
Autor:
Christopher L Axelrod, William T King, Gangarao Davuluri, Robert C Noland, Jacob Hall, Michaela Hull, Wagner S Dantas, Elizabeth RM Zunica, Stephanie J Alexopoulos, Kyle L Hoehn, Ingeborg Langohr, Krisztian Stadler, Haylee Doyle, Eva Schmidt, Stephan Nieuwoudt, Kelly Fitzgerald, Kathryn Pergola, Hisashi Fujioka, Jacob T Mey, Ciaran Fealy, Anny Mulya, Robbie Beyl, Charles L Hoppel, John P Kirwan
Publikováno v:
EMBO Molecular Medicine, Vol 12, Iss 7, Pp n/a-n/a (2020)
Abstract Obesity is a leading cause of preventable death worldwide. Despite this, current strategies for the treatment of obesity remain ineffective at achieving long‐term weight control. This is due, in part, to difficulties in identifying tolerab
Externí odkaz:
https://doaj.org/article/61fe5cb6b2dd4631b169f643148abc19
Autor:
Alexander J. Knights, Emily J. Vohralik, Peter J. Houweling, Elizabeth S. Stout, Laura J. Norton, Stephanie J. Alexopoulos, Jinfen. J. Yik, Hanapi Mat Jusoh, Ellen M. Olzomer, Kim S. Bell-Anderson, Kathryn N. North, Kyle L. Hoehn, Merlin Crossley, Kate G. R. Quinlan
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-12 (2020)
Immune cells are important regulators of adipose tissue function, including adaptive thermogenesis. Here the authors show that mice with Krüppel-like factor 3 (KLF3) deficiency in bone marrow-derived cells have increased adipose tissue beiging which
Externí odkaz:
https://doaj.org/article/c3cf746046c44c4288224f72b4e3c524
Autor:
Stephanie J. Alexopoulos, Sing-Young Chen, Amanda E. Brandon, Joseph M. Salamoun, Frances L. Byrne, Christopher J. Garcia, Martina Beretta, Ellen M. Olzomer, Divya P. Shah, Ashleigh M. Philp, Stefan R. Hargett, Robert T. Lawrence, Brendan Lee, James Sligar, Pascal Carrive, Simon P. Tucker, Andrew Philp, Carolin Lackner, Nigel Turner, Gregory J. Cooney, Webster L. Santos, Kyle L. Hoehn
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-13 (2020)
Obesity is a global pandemic with limited treatment options. Here, the authors show evidence in mice that the mitochondrial uncoupler BAM15 effectively induces fat loss without affecting food intake or compromising lean body mass.
Externí odkaz:
https://doaj.org/article/49822901a6bc47aea8285786f6119e85
Autor:
Frances L. Byrne, Ellen M. Olzomer, Gabriella R. Marriott, Lake-Ee Quek, Alice Katen, Jacky Su, Marin E. Nelson, Gene Hart-Smith, Mark Larance, Veronica F. Sebesfi, Jeff Cuff, Gabriella E. Martyn, Elizabeth Childress, Stephanie J. Alexopoulos, Ivan K. Poon, Maree C. Faux, Antony W. Burgess, Glen Reid, Joshua A. McCarroll, Webster L. Santos, Kate GR. Quinlan, Nigel Turner, Daniel J. Fazakerley, Naresh Kumar, Kyle L. Hoehn
Publikováno v:
Redox Biology, Vol 28, Iss , Pp - (2020)
A hallmark of cancer cells is their ability to reprogram nutrient metabolism. Thus, disruption to this phenotype is a potential avenue for anti-cancer therapy. Herein we used a phenotypic chemical library screening approach to identify molecules that
Externí odkaz:
https://doaj.org/article/5e4c5baf666144d5a43fe60f14c4e6fb
Autor:
Joseph M. Salamoun, Stefan R. Hargett, Martina Beretta, Stephanie J. Alexopoulos, Ellen M. Olzomer, Divya P. Shah, Murray Jacob H, Webster L. Santos, Sing-Young Chen, Christopher J Garcia, Simon P. Tucker, Kyle L. Hoehn
Publikováno v:
Journal of Medicinal Chemistry. 63:6203-6224
Small molecule mitochondrial uncouplers have recently garnered great interest for their potential in treating nonalcoholic steatohepatitis (NASH). In this study, we report the structure-activity relationship profiling of a 6-amino[1,2,5]oxadiazolo[3,
Autor:
Marthe-Susanna Wegner, Lisa Gruber, Nina Schömel, Ellen M. Olzomer, Kyle L. Hoehn, Stephanie J. Alexopoulos, Nerea Ferreirós, Robert Gurke, Gerd Geisslinger, Frances L. Byrne, Sandra Trautmann, Dominique Thomas
Publikováno v:
Scientific Reports, Vol 10, Iss 1, Pp 1-13 (2020)
Scientific Reports
Scientific Reports
The only enzyme in the glycosphingolipid (GSL) metabolic pathway, which produces glucosylceramide (GlcCer) de novo is UDP-glucose ceramide glucosyltransferase (UGCG). UGCG is linked to pro-cancerous processes such as multidrug resistance development
Autor:
Stefan R. Hargett, Elizabeth S. Childress, Joseph M. Salamoun, Jose A Santiago-Rivera, Divya P. Shah, Christopher J Garcia, Webster L. Santos, Sing-Young Chen, Kyle L. Hoehn, Stephanie J. Alexopoulos, Yumin Dai, Simon P. Tucker
Publikováno v:
J Med Chem
Small molecule mitochondrial uncouplers are emerging as a new class of molecules for the treatment of nonalcoholic steatohepatitis. We utilized BAM15, a potent protonophore that uncouples the mitochondria without depolarizing the plasma membrane, as
Autor:
Michael J. Bertoldo, Ying Hu, Kirsty A Walters, Melissa C Edwards, Hoehn L Kyle, Divya P. Shah, Stephanie J. Alexopoulos, Ali Aflatounian, Valentina Rodriguez Paris
Publikováno v:
Journal of the Endocrine Society
Polycystic ovary syndrome (PCOS) is a prevalent endocrine condition characterized by endocrine, reproductive and metabolic dysfunction. At present, there is no cure for PCOS and current treatments are suboptimal. Obesity and adverse metabolic feature
Autor:
Sing-Young Chen, Simon P. Tucker, Stefan R. Hargett, Elizabeth S. Childress, Martina Beretta, Kyle L. Hoehn, Kate G. R. Quinlan, Stephanie J. Alexopoulos, Webster L. Santos, Isabella Aleksovska, Charles G. Cranfield, Divya P. Shah, Ellen M. Olzomer, Joseph M. Salamoun, Tristan Rawling, Ariane Roseblade, Margaret J. Morris
Publikováno v:
Metabolism: clinical and experimental. 117
Aims Mitochondrial uncouplers decrease caloric efficiency and have potential therapeutic benefits for the treatment of obesity and related metabolic disorders. Herein we investigate the metabolic and physiologic effects of a recently identified small
Autor:
Jacob T. Mey, Gangarao Davuluri, Ciaran E. Fealy, Anny Mulya, Ingeborg M. Langohr, Elizabeth R M Zunica, Kathryn Pergola, Charles L. Hoppel, Christopher L. Axelrod, Kelly M. Fitzgerald, Krisztian Stadler, Michaela Hull, Hisashi Fujioka, Haylee Doyle, Stephanie J. Alexopoulos, Kyle L. Hoehn, Eva Schmidt, Robert C. Noland, Robbie A. Beyl, Stephan Nieuwoudt, Wagner S Dantas, Jacob Hall, John P. Kirwan, William T. King
Publikováno v:
EMBO Molecular Medicine, Vol 12, Iss 7, Pp n/a-n/a (2020)
EMBO Molecular Medicine
EMBO Molecular Medicine
Obesity is a leading cause of preventable death worldwide. Despite this, current strategies for the treatment of obesity remain ineffective at achieving long‐term weight control. This is due, in part, to difficulties in identifying tolerable and ef