Zobrazeno 1 - 10
of 85
pro vyhledávání: '"Stephanie J, Cragg"'
Autor:
Polina Kosillo, Kamran M Ahmed, Erin E Aisenberg, Vasiliki Karalis, Bradley M Roberts, Stephanie J Cragg, Helen S Bateup
Publikováno v:
eLife, Vol 11 (2022)
The mTOR pathway is an essential regulator of cell growth and metabolism. Midbrain dopamine neurons are particularly sensitive to mTOR signaling status as activation or inhibition of mTOR alters their morphology and physiology. mTOR exists in two dis
Externí odkaz:
https://doaj.org/article/7be27d522af2436c8c1b4b13a65c9cf5
Autor:
Bradley M. Roberts, Natalie M. Doig, Katherine R. Brimblecombe, Emanuel F. Lopes, Ruth E. Siddorn, Sarah Threlfell, Natalie Connor-Robson, Nora Bengoa-Vergniory, Nicholas Pasternack, Richard Wade-Martins, Peter J. Magill, Stephanie J. Cragg
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-17 (2020)
GABA transporters expressed in the striatum may affect behaviour. Here the authors investigate the contribution of GABA transporters on astrocytes to the regulation of dopamine release in the striatum, and show decreased expression of GAT-1 and GAT-3
Externí odkaz:
https://doaj.org/article/f4c24c167c97494e92ebdf24a5229496
Autor:
Mark D. Condon, Nicola J. Platt, Yan-Feng Zhang, Bradley M. Roberts, Michael A. Clements, Stefania Vietti-Michelina, Min-Yee Tseu, Katherine R. Brimblecombe, Sarah Threlfell, Edward O. Mann, Stephanie J. Cragg
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-15 (2019)
Dopamine release in the striatum has important roles in action selection and in disorders such as Parkinson’s disease. The authors here show that short-term plasticity of dopamine release is strongly determined by axonal activation and dopamine tra
Externí odkaz:
https://doaj.org/article/b1b396a19d0e49f0914ab423562f96e0
Autor:
Sarah Threlfell, Amir Saeid Mohammadi, Brent J. Ryan, Natalie Connor-Robson, Nicola J. Platt, Rishi Anand, Florence Serres, Trevor Sharp, Nora Bengoa-Vergniory, Richard Wade-Martins, Andrew Ewing, Stephanie J. Cragg, Katherine R. Brimblecombe
Publikováno v:
Frontiers in Cellular Neuroscience, Vol 15 (2021)
Striatal dopamine transporters (DAT) powerfully regulate dopamine signaling, and can contribute risk to degeneration in Parkinson’s disease (PD). DATs can interact with the neuronal protein α-synuclein, which is associated with the etiology and mo
Externí odkaz:
https://doaj.org/article/d94e14e6aa624a13a530f30f01d4e044
Publikováno v:
Management, Vol 25, Iss 3 (2020)
Research Question: This paper investigates how the social franchising approach may enhance the sustainability and capability of Foster Home NGOs in the Global South. Motivation: While many programmes exist to address issues such as poverty and lack o
Externí odkaz:
https://doaj.org/article/3b975f8aca7c4f1e890221216aafc469
Autor:
Benjamin H.M. Hunn, Siv Vingill, Sarah Threlfell, Javier Alegre-Abarrategui, Morgane Magdelyns, Thierry Deltheil, Nora Bengoa-Vergniory, Peter L. Oliver, Milena Cioroch, Natalie M. Doig, David M. Bannerman, Stephanie J. Cragg, Richard Wade-Martins
Publikováno v:
Cell Reports, Vol 29, Iss 4, Pp 920-931.e7 (2019)
Summary: Parkinson’s disease (PD) is characterized by the death of dopamine neurons in the substantia nigra pars compacta (SNc) and accumulation of α-synuclein. Impaired autophagy has been implicated and activation of autophagy proposed as a treat
Externí odkaz:
https://doaj.org/article/173e703e2233467d9c3680e7a98ca772
Publikováno v:
Brain.
Parkinson’s disease is the second most common neurodegenerative disease and yet the early pathophysiological events of the condition and sequences of dysfunction remain unclear. The loss of dopaminergic neurons and reduced levels of striatal dopami
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::0253d227801dcdfa6ced1414c15fa058
https://doi.org/10.1093/brain/awad064
https://doi.org/10.1093/brain/awad064
Publikováno v:
Cells, Vol 10, Iss 3, p 709 (2021)
Striatal dopamine (DA) release is critical for motivated actions and reinforcement learning, and is locally influenced at the level of DA axons by other striatal neurotransmitters. Here, we review a wealth of historical and more recently refined evid
Externí odkaz:
https://doaj.org/article/bf910cc69ccc4bfca80052752e23c97b
Publikováno v:
Neurobiology of Disease, Vol 82, Iss , Pp 262-268 (2015)
Dopamine function is disturbed in Parkinson's disease (PD), but whether and how release of dopamine from surviving neurons is altered has long been debated. Nicotinic acetylcholine receptors (nAChRs) on dopamine axons powerfully govern dopamine relea
Externí odkaz:
https://doaj.org/article/bcae94cde384400aaa3046efc02857ab
Pauses in Striatal Cholinergic Interneurons: What is Revealed by Their Common Themes and Variations?
Autor:
Yan-Feng Zhang, Stephanie J. Cragg
Publikováno v:
Frontiers in Systems Neuroscience, Vol 11 (2017)
Striatal cholinergic interneurons, the so-called tonically active neurons (TANs), pause their firing in response to sensory cues and rewards during classical conditioning and instrumental tasks. The respective pause responses observed can demonstrate
Externí odkaz:
https://doaj.org/article/0d9e82d1550e486298d4cd99934148d6