Zobrazeno 1 - 10
of 40
pro vyhledávání: '"Stephanie J, Church"'
Publikováno v:
Frontiers in Neuroscience, Vol 18 (2024)
BackgroundDementia with Lewy bodies (DLB) can be difficult to distinguish from Alzheimer’s disease (AD) and Parkinson’s disease dementia (PDD) at different stages of its progression due to some overlaps in the clinical and neuropathological prese
Externí odkaz:
https://doaj.org/article/dc0b770d0c4c4f41a9adf842be695bbb
Autor:
Melissa Scholefield, Stephanie J. Church, George Taylor, David Knight, Richard D. Unwin, Garth J. S. Cooper
Publikováno v:
npj Parkinson's Disease, Vol 9, Iss 1, Pp 1-10 (2023)
Abstract Parkinson’s disease (PD) is one of the most common neurodegenerative diseases, most commonly characterised by motor dysfunction, but also with a high prevalence of cognitive decline in the decades following diagnosis—a condition known as
Externí odkaz:
https://doaj.org/article/f02d70b9f7a349db9090cc49b4e80243
Autor:
Sasha A. Philbert, Jingshu Xu, Melissa Scholefield, Stefano Patassini, Stephanie J. Church, Richard D. Unwin, Federico Roncaroli, Garth J. S. Cooper
Publikováno v:
Frontiers in Molecular Neuroscience, Vol 16 (2023)
IntroductionVascular dementia (VaD) is one of the most common causes of dementia among the elderly. Despite this, the molecular basis of VaD remains poorly characterized when compared to other age-related dementias. Pervasive cerebral elevations of u
Externí odkaz:
https://doaj.org/article/7512390f6448457da5107a8761bc0857
Autor:
Agnese Padula, Raffaella Petruzzelli, Sasha A. Philbert, Stephanie J. Church, Federica Esposito, Severo Campione, Marcello Monti, Filomena Capolongo, Claudia Perna, Edoardo Nusco, Hartmut H. Schmidt, Alberto Auricchio, Garth J.S. Cooper, Roman Polishchuk, Pasquale Piccolo
Publikováno v:
Molecular Therapy: Methods & Clinical Development, Vol 26, Iss , Pp 495-504 (2022)
Wilson disease (WD) is a genetic disorder of copper homeostasis, caused by deficiency of the copper transporter ATP7B. Gene therapy with recombinant adeno-associated vectors (AAV) holds promises for WD treatment. However, the full-length human ATP7B
Externí odkaz:
https://doaj.org/article/9b06f42f269f4eb08bec78339d8b5af7
Autor:
Sasha A. Philbert, Sarah J. Schönberger, Jingshu Xu, Stephanie J. Church, Richard D. Unwin, Garth J.S. Cooper
Publikováno v:
EBioMedicine, Vol 86, Iss , Pp 104317- (2022)
Summary: Background: Type-2 diabetes (T2D) is characterized by chronic hyperglycaemia and glucose-evoked organ damage, and displays systemic copper overload, elevated risk of impaired cognitive function, and epidemiological links to sporadic Alzheime
Externí odkaz:
https://doaj.org/article/7d32fec164df4d2ba3286b55ad293375
Pan-cerebral sodium elevations in vascular dementia: Evidence for disturbed brain-sodium homeostasis
Autor:
Sasha A. Philbert, Jingshu Xu, Stephanie J. Church, Richard D. Unwin, Federico Roncaroli, Garth J. S. Cooper
Publikováno v:
Frontiers in Aging Neuroscience, Vol 14 (2022)
Vascular dementia (VaD) is the second most common cause of cognitive impairment amongst the elderly. However, there are no known disease-modifying therapies for VaD, probably due to incomplete understanding of the molecular basis of the disease. Desp
Externí odkaz:
https://doaj.org/article/55008665761749babd1effdcee0407a7
Autor:
Sasha A. Philbert, Jingshu Xu, Melissa Scholefield, Stephanie J. Church, Richard D. Unwin, Garth J. S. Cooper
Publikováno v:
Frontiers in Aging Neuroscience, Vol 14 (2022)
Vascular dementia (VaD) is thought to be the second most common cause of age-related dementia amongst the elderly. However, at present, there are no available disease-modifying therapies for VaD, probably due to insufficient understanding about the m
Externí odkaz:
https://doaj.org/article/39efd04749634e7b828ce0cb6c4e5f5b
Autor:
Melissa Scholefield, Stephanie J. Church, Jingshu Xu, Stefano Patassini, Federico Roncaroli, Nigel M. Hooper, Richard D. Unwin, Garth J. S. Cooper
Publikováno v:
Frontiers in Molecular Neuroscience, Vol 14 (2021)
Widespread elevations in brain urea have, in recent years, been reported in certain types of age-related dementia, notably Alzheimer’s disease (AD) and Huntington’s disease (HD). Urea increases in these diseases are substantive, and approximate i
Externí odkaz:
https://doaj.org/article/19001ef99efe4d14957c087415473dbc
Autor:
Sarah Kassab, Paul Begley, Stephanie J. Church, Sanziana M. Rotariu, Cleo Chevalier-Riffard, Andrew W. Dowsey, Alexander M. Phillips, Leo A.H. Zeef, Ben Grayson, Joanna C. Neill, Garth J.S. Cooper, Richard D. Unwin, Natalie J. Gardiner
Publikováno v:
Molecular Metabolism, Vol 28, Iss , Pp 107-119 (2019)
Objective: The impact of diabetes mellitus on the central nervous system is less widely studied than in the peripheral nervous system, but there is increasing evidence that it elevates the risk of developing cognitive deficits. The aim of this study
Externí odkaz:
https://doaj.org/article/5729f0504db341cd97c70ad009936b48
Autor:
Melissa Scholefield, Stephanie J. Church, Jingshu Xu, Stefano Patassini, Federico Roncaroli, Nigel M. Hooper, Richard D. Unwin, Garth J. S. Cooper
Publikováno v:
Frontiers in Aging Neuroscience, Vol 13 (2021)
Several studies of Parkinson's disease (PD) have reported dysregulation of cerebral metals, particularly decreases in copper and increases in iron in substantia nigra (SN). However, few studies have investigated regions outside the SN, fewer have mea
Externí odkaz:
https://doaj.org/article/c771a8427ef54805a19961581ac0aefb