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Autor:
Ashley E. Ciecko, Yu Wang, Stephanie Harleston, Amber Drewek, David V. Serreze, Aron M. Geurts, Chien-Wei Lin, Yi-Guang Chen
Publikováno v:
The Journal of Immunology. 210:935-946
IL-21 is essential for type 1 diabetes (T1D) development in the NOD mouse model. IL-21–expressing CD4 T cells are present in pancreatic islets where they contribute to T1D progression. However, little is known about their phenotype and differentiat