Zobrazeno 1 - 10
of 29
pro vyhledávání: '"Stephanie Harkins"'
Autor:
Christopher C Kemball, Stephanie Harkins, Jason K Whitmire, Claudia T Flynn, Ralph Feuer, J Lindsay Whitton
Publikováno v:
PLoS Pathogens, Vol 5, Iss 10, p e1000618 (2009)
Many viruses encode proteins whose major function is to evade or disable the host T cell response. Nevertheless, most viruses are readily detected by host T cells, and induce relatively strong T cell responses. Herein, we employ transgenic CD4(+) and
Externí odkaz:
https://doaj.org/article/cfa169a10cf548db966c297a81118ccb
Autor:
Haoyang Li, Tierra Buck, Michelle Zandonatti, Jieyun Yin, Alex Moon-Walker, Jingru Fang, Anatoliy Koval, Megan L. Heinrich, Megan M. Rowland, Ruben Diaz Avalos, Sharon L. Schendel, Diptiben Parekh, Dawid Zyla, Adrian Enriquez, Stephanie Harkins, Brian Sullivan, Victoria Smith, Onyeka Chukwudozie, Reika Watanabe, James E. Robinson, Robert F. Garry, Luis M. Branco, Kathryn M. Hastie, Erica Ollmann Saphire
Publikováno v:
Sci Transl Med
Developing potent therapeutics and effective vaccines are the ultimate goals in controlling infectious diseases. Lassa virus (LASV), the causative pathogen of Lassa fever (LF), infects hundreds of thousands annually, but effective antivirals or vacci
Autor:
Megan L. Heinrich, Michelle Zandonatti, Kathryn M. Hastie, Thomas W. Geisbert, Erica Ollmann Saphire, James E. Robinson, Robert W. Cross, Robert F. Garry, Megan M. Rowland, Stephanie Harkins, Luis M. Branco, Anatoliy P. Koval
Publikováno v:
Cell
Summary Lassa virus (LASV) causes hemorrhagic fever and is endemic in West Africa. Protective antibody responses primarily target the LASV surface glycoprotein (GPC), and GPC-B competition group antibodies often show potent neutralizing activity in h
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e636320bc68f46ac305da4f7786ff9f5
https://europepmc.org/articles/PMC6814208/
https://europepmc.org/articles/PMC6814208/
Autor:
Haoyang Li, Robert F. Garry, Michelle Zandonatti, Stephanie Harkins, Luís C. Branco, Adrian Enriquez, Erica Ollmann Saphire, Kathryn M. Hastie, Tierra Buck
Publikováno v:
Microscopy and Microanalysis. 26:568-568
Publikováno v:
Autophagy
RNA viruses modify intracellular membranes to produce replication scaffolds. In pancreatic cells, coxsackievirus B3 (CVB3) hijacks membranes from the autophagy pathway, and in vivo disruption of acinar cell autophagy dramatically delays CVB3 replicat
Autor:
Claudia T. Flynn, Kwesi Frimpong-Boateng, J. Lindsay Whitton, Taishi Kimura, Stephanie Harkins
Publikováno v:
Virology. 512
Type B coxsackieviruses (CVB) can cause myocarditis and dilated cardiomyopathy (DCM), a potentially-fatal sequela that has been correlated to the persistence of viral RNA. Herein, we demonstrate that cardiac RNA persistence can be established even af
Autor:
Nadine Althof, J. L. Whitton, Claudia T. Flynn, Christopher C. Kemball, Stephanie Harkins, Mehrdad Alirezaei
Publikováno v:
Journal of Virology. 88:5087-5099
Acute coxsackievirus B3 (CVB3) infection is one of the most prevalent causes of acute myocarditis, a disease that frequently is identified only after the sudden death of apparently healthy individuals. CVB3 infects cardiomyocytes, but the infection i
Autor:
J. Lindsay Whitton, Stephanie Harkins
Publikováno v:
Transgenic research. 25(5)
Transgenic mice expressing a tamoxifen-inducible Cre recombinase specifically in cardiomyocytes were generated in 2001 and are in widespread use, having been employed in >150 published studies. However, several groups recently have reported that tamo
Autor:
William B. Kiosses, Christopher C. Kemball, Malcolm R. Wood, Mehrdad Alirezaei, Stephanie Harkins, Claudia T. Flynn, J. Lindsay Whitton
Publikováno v:
Journal of Virology. 84:12110-12124
Autophagy can play an important part in protecting host cells during virus infection, and several viruses have developed strategies by which to evade or even exploit this homeostatic pathway. Tissue culture studies have shown that poliovirus, an ente
Autor:
Ralph Feuer, William B. Kiosses, Stephanie Harkins, Chelsea M. Ruller, J. Lindsay Whitton, Paul E. Gilbert, Natalie Gude, Jenna M. Tabor-Godwin, Mark A. Sussman, Kelly S. Doran, Nolan Bagalso, Christopher T. Cornell, Robb R. Pagarigan, Naili An
Publikováno v:
Journal of Neuroscience. 30:8676-8691
Enterovirus infection in newborn infants is a significant cause of aseptic meningitis and encephalitis. Using a neonatal mouse model, we previously determined that coxsackievirus B3 (CVB3) preferentially targets proliferating neural stem cells locate