Zobrazeno 1 - 3
of 3
pro vyhledávání: '"Stephanie H. Hoyt"'
Autor:
Colin W. Garvie, Xiaoyun Wu, Malvina Papanastasiou, Sooncheol Lee, James Fuller, Gavin R. Schnitzler, Steven W. Horner, Andrew Baker, Terry Zhang, James P. Mullahoo, Lindsay Westlake, Stephanie H. Hoyt, Marcus Toetzl, Matthew J. Ranaghan, Luc de Waal, Joseph McGaunn, Bethany Kaplan, Federica Piccioni, Xiaoping Yang, Martin Lange, Adrian Tersteegen, Donald Raymond, Timothy A. Lewis, Steven A. Carr, Andrew D. Cherniack, Christopher T. Lemke, Matthew Meyerson, Heidi Greulich
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-16 (2021)
The small molecule DNMDP acts as a velcrin by inducing complex formation between phosphodiesterase PDE3A and SLFN12, which kills cancer cells that express sufficient levels of both proteins. Here, the authors present the cryo-EM structure of the DNMD
Externí odkaz:
https://doaj.org/article/8c9d393dbd6b4b13a8ba16d21da8b36d
Autor:
Adrian Tersteegen, Stephanie H. Hoyt, Steven A. Carr, Donald Raymond, Christopher T. Lemke, Federica Piccioni, James Mullahoo, Martin Lange, Xiaoping Yang, Bethany Kaplan, Colin W. Garvie, Andrew Baker, Marcus Toetzl, Heidi Greulich, Malvina Papanastasiou, Steven Horner, Luc de Waal, Timothy A. Lewis, James R. Fuller, Sooncheol Lee, Lindsay Westlake, Andrew D. Cherniack, Joseph McGaunn, Terry Zhang, Gavin R. Schnitzler, Matthew Meyerson, Matthew J. Ranaghan, Xiaoyun Wu
Publikováno v:
'Nature Communications ', vol: 12, pages: 4375-1-4375-16 (2021)
Nature Communications, Vol 12, Iss 1, Pp 1-16 (2021)
Nature Communications
Nature Communications, Vol 12, Iss 1, Pp 1-16 (2021)
Nature Communications
DNMDP and related compounds, or velcrins, induce complex formation between the phosphodiesterase PDE3A and the SLFN12 protein, leading to a cytotoxic response in cancer cells that express elevated levels of both proteins. The mechanisms by which velc
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6cfd121cbb4144ac667f5c20f822fddc
https://doi.org/10.1038/s41467-021-24495-w
https://doi.org/10.1038/s41467-021-24495-w
Autor:
Colin W. Garvie, Martin Lange, Stephanie H. Hoyt, James Mullahoo, Matthew Meyerson, Andrew D. Cherniack, Terry Zhang, Joseph McGaunn, Xiaoyun Wu, Steven A. Carr, Heidi Greulich, Xiaoping Yang, Gavin R. Schnitzler, Andrew Baker, Bethany Kaplan, Sooncheol Lee, Federica Piccioni, Malvina Papanastasiou
Publikováno v:
Cancer Research. 81:1219-1219
PDE3A-SLFN12 complex formation is induced by a class of compounds, now called “velcrins”, exemplified by the small molecule, DNMDP. Cancer cells that express elevated levels of PDE3A and SLFN12 are sensitive to a velcrin-mediated cytotoxic respon
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::1e1a28982c59b9d703244bae5dda08b8
https://doi.org/10.1158/1538-7445.am2021-1219
https://doi.org/10.1158/1538-7445.am2021-1219